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Gene: MBD1 |
Gene summary for MBD1 |
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Gene information | Species | Human | Gene symbol | MBD1 | Gene ID | 4152 |
Gene name | methyl-CpG binding domain protein 1 | |
Gene Alias | CXXC3 | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A8K654 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4152 | MBD1 | LZE4T | Human | Esophagus | ESCC | 1.12e-03 | 2.44e-01 | 0.0811 |
4152 | MBD1 | LZE7T | Human | Esophagus | ESCC | 1.32e-07 | 4.00e-01 | 0.0667 |
4152 | MBD1 | LZE8T | Human | Esophagus | ESCC | 4.49e-02 | 8.70e-02 | 0.067 |
4152 | MBD1 | LZE20T | Human | Esophagus | ESCC | 1.44e-05 | 7.30e-02 | 0.0662 |
4152 | MBD1 | LZE24T | Human | Esophagus | ESCC | 5.11e-09 | 2.19e-01 | 0.0596 |
4152 | MBD1 | P1T-E | Human | Esophagus | ESCC | 1.10e-13 | 5.22e-01 | 0.0875 |
4152 | MBD1 | P2T-E | Human | Esophagus | ESCC | 3.64e-20 | 3.44e-01 | 0.1177 |
4152 | MBD1 | P4T-E | Human | Esophagus | ESCC | 3.02e-17 | 4.94e-01 | 0.1323 |
4152 | MBD1 | P5T-E | Human | Esophagus | ESCC | 7.92e-13 | 1.46e-01 | 0.1327 |
4152 | MBD1 | P8T-E | Human | Esophagus | ESCC | 1.19e-13 | 3.69e-01 | 0.0889 |
4152 | MBD1 | P9T-E | Human | Esophagus | ESCC | 9.67e-15 | 4.04e-01 | 0.1131 |
4152 | MBD1 | P10T-E | Human | Esophagus | ESCC | 2.60e-29 | 3.42e-01 | 0.116 |
4152 | MBD1 | P11T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.17e-01 | 0.1426 |
4152 | MBD1 | P12T-E | Human | Esophagus | ESCC | 2.61e-08 | 2.50e-01 | 0.1122 |
4152 | MBD1 | P15T-E | Human | Esophagus | ESCC | 6.58e-11 | 2.34e-01 | 0.1149 |
4152 | MBD1 | P16T-E | Human | Esophagus | ESCC | 2.35e-22 | 3.36e-01 | 0.1153 |
4152 | MBD1 | P17T-E | Human | Esophagus | ESCC | 2.38e-10 | 1.93e-01 | 0.1278 |
4152 | MBD1 | P19T-E | Human | Esophagus | ESCC | 6.59e-05 | 5.82e-01 | 0.1662 |
4152 | MBD1 | P20T-E | Human | Esophagus | ESCC | 3.62e-20 | 4.22e-01 | 0.1124 |
4152 | MBD1 | P21T-E | Human | Esophagus | ESCC | 3.89e-16 | 3.88e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000756820 | Esophagus | ESCC | aging | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
GO:00100016 | Esophagus | ESCC | glial cell differentiation | 129/8552 | 225/18723 | 2.73e-04 | 1.65e-03 | 129 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:0006304 | Esophagus | ESCC | DNA modification | 68/8552 | 120/18723 | 9.95e-03 | 3.42e-02 | 68 |
GO:00140131 | Esophagus | ESCC | regulation of gliogenesis | 59/8552 | 103/18723 | 1.17e-02 | 3.91e-02 | 59 |
GO:003166722 | Liver | HCC | response to nutrient levels | 276/7958 | 474/18723 | 2.30e-12 | 1.08e-10 | 276 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:000941022 | Liver | HCC | response to xenobiotic stimulus | 248/7958 | 462/18723 | 6.47e-07 | 1.02e-05 | 248 |
GO:005105221 | Liver | HCC | regulation of DNA metabolic process | 198/7958 | 359/18723 | 7.62e-07 | 1.17e-05 | 198 |
GO:000756822 | Liver | HCC | aging | 185/7958 | 339/18723 | 4.28e-06 | 5.50e-05 | 185 |
GO:00323552 | Liver | HCC | response to estradiol | 81/7958 | 141/18723 | 2.39e-04 | 1.79e-03 | 81 |
GO:00507674 | Liver | HCC | regulation of neurogenesis | 181/7958 | 364/18723 | 3.00e-03 | 1.40e-02 | 181 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
MBD1 | TFH | Breast | Precancer | CHI3L1,USPL1,ADTRP, etc. | 3.54e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MBD1 | SNV | Missense_Mutation | rs199727558 | c.1409C>T | p.Pro470Leu | p.P470L | Q9UIS9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-4741-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
MBD1 | SNV | Missense_Mutation | novel | c.207N>C | p.Leu69Phe | p.L69F | Q9UIS9 | protein_coding | tolerated(0.17) | probably_damaging(0.998) | TCGA-CR-7364-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
MBD1 | insertion | Frame_Shift_Ins | novel | c.1165_1166dupGT | p.Trp390SerfsTer33 | p.W390Sfs*33 | Q9UIS9 | protein_coding | TCGA-CN-6997-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD | ||
MBD1 | SNV | Missense_Mutation | c.1508N>T | p.Ala503Val | p.A503V | Q9UIS9 | protein_coding | tolerated_low_confidence(0.34) | benign(0.438) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
MBD1 | deletion | Frame_Shift_Del | novel | c.101_102delNN | p.Tyr34LeufsTer14 | p.Y34Lfs*14 | Q9UIS9 | protein_coding | TCGA-KK-A7B3-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | PD | ||
MBD1 | deletion | Frame_Shift_Del | novel | c.1631delC | p.Pro544GlnfsTer29 | p.P544Qfs*29 | Q9UIS9 | protein_coding | TCGA-KK-A8IL-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | ||
MBD1 | insertion | Frame_Shift_Ins | novel | c.103_104insT | p.Tyr35LeufsTer14 | p.Y35Lfs*14 | Q9UIS9 | protein_coding | TCGA-V1-A8WV-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | lhrh | CR | ||
MBD1 | SNV | Missense_Mutation | novel | c.1666G>A | p.Ala556Thr | p.A556T | Q9UIS9 | protein_coding | tolerated_low_confidence(0.2) | probably_damaging(0.997) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
MBD1 | SNV | Missense_Mutation | novel | c.152N>T | p.Arg51Leu | p.R51L | Q9UIS9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BR-6456-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MBD1 | SNV | Missense_Mutation | c.1268C>T | p.Pro423Leu | p.P423L | Q9UIS9 | protein_coding | deleterious(0.02) | benign(0.306) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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