![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MAST3 |
Gene summary for MAST3 |
![]() |
Gene information | Species | Human | Gene symbol | MAST3 | Gene ID | 23031 |
Gene name | microtubule associated serine/threonine kinase 3 | |
Gene Alias | MAST3 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | O60307 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23031 | MAST3 | HCC1_Meng | Human | Liver | HCC | 3.46e-12 | -3.69e-03 | 0.0246 |
23031 | MAST3 | HCC1 | Human | Liver | HCC | 2.93e-04 | 3.09e+00 | 0.5336 |
23031 | MAST3 | HCC2 | Human | Liver | HCC | 1.39e-07 | 2.72e+00 | 0.5341 |
23031 | MAST3 | S014 | Human | Liver | HCC | 5.35e-12 | 4.94e-01 | 0.2254 |
23031 | MAST3 | S015 | Human | Liver | HCC | 9.45e-09 | 4.89e-01 | 0.2375 |
23031 | MAST3 | S016 | Human | Liver | HCC | 2.18e-13 | 4.85e-01 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001810511 | Liver | HCC | peptidyl-serine phosphorylation | 169/7958 | 315/18723 | 3.86e-05 | 3.81e-04 | 169 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAST3 | SNV | Missense_Mutation | novel | c.3304T>A | p.Ser1102Thr | p.S1102T | O60307 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-CV-7446-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAST3 | SNV | Missense_Mutation | novel | c.173N>T | p.Pro58Leu | p.P58L | O60307 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAST3 | SNV | Missense_Mutation | rs200457728 | c.2854N>A | p.Val952Ile | p.V952I | O60307 | protein_coding | tolerated(1) | benign(0.015) | TCGA-CV-A45X-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAST3 | SNV | Missense_Mutation | novel | c.1150N>C | p.Val384Leu | p.V384L | O60307 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-KU-A66T-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MAST3 | SNV | Missense_Mutation | novel | c.2382N>T | p.Glu794Asp | p.E794D | O60307 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAST3 | SNV | Missense_Mutation | novel | c.2980N>C | p.Glu994Gln | p.E994Q | O60307 | protein_coding | tolerated(0.19) | benign(0.015) | TCGA-UF-A7JA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAST3 | SNV | Missense_Mutation | novel | c.460N>A | p.Arg154Ser | p.R154S | O60307 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-G9-6343-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
MAST3 | SNV | Missense_Mutation | rs752040125 | c.3877G>A | p.Val1293Met | p.V1293M | O60307 | protein_coding | deleterious_low_confidence(0) | benign(0.312) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MAST3 | SNV | Missense_Mutation | c.1090G>A | p.Glu364Lys | p.E364K | O60307 | protein_coding | deleterious(0) | benign(0.27) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
MAST3 | SNV | Missense_Mutation | c.55N>T | p.Pro19Ser | p.P19S | O60307 | protein_coding | tolerated(0.18) | benign(0.018) | TCGA-CG-4474-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23031 | MAST3 | KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | inhibitor | 252827499 |
Page: 1 |