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Gene: MAP7D2 |
Gene summary for MAP7D2 |
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Gene information | Species | Human | Gene symbol | MAP7D2 | Gene ID | 256714 |
Gene name | MAP7 domain containing 2 | |
Gene Alias | MAP7D2 | |
Cytomap | Xp22.12 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q96T17 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
256714 | MAP7D2 | C43 | Human | Oral cavity | OSCC | 2.05e-28 | 6.15e-01 | 0.1704 |
256714 | MAP7D2 | C46 | Human | Oral cavity | OSCC | 3.19e-03 | 8.29e-02 | 0.1673 |
256714 | MAP7D2 | LN22 | Human | Oral cavity | OSCC | 4.06e-06 | 7.92e-01 | 0.1733 |
256714 | MAP7D2 | LN38 | Human | Oral cavity | OSCC | 8.69e-03 | 4.00e-01 | 0.168 |
256714 | MAP7D2 | LN46 | Human | Oral cavity | OSCC | 1.74e-05 | 2.94e-01 | 0.1666 |
256714 | MAP7D2 | SYSMH1 | Human | Oral cavity | OSCC | 5.62e-06 | 1.10e-01 | 0.1127 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP7D2 | SNV | Missense_Mutation | novel | c.359T>C | p.Leu120Pro | p.L120P | Q96T17 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAP7D2 | SNV | Missense_Mutation | novel | c.2130N>T | p.Met710Ile | p.M710I | Q96T17 | protein_coding | tolerated(0.17) | benign(0.188) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MAP7D2 | SNV | Missense_Mutation | novel | c.1965N>A | p.Phe655Leu | p.F655L | Q96T17 | protein_coding | tolerated(0.16) | possibly_damaging(0.735) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MAP7D2 | SNV | Missense_Mutation | novel | c.742N>T | p.Ala248Ser | p.A248S | Q96T17 | protein_coding | tolerated(0.16) | possibly_damaging(0.894) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MAP7D2 | insertion | Frame_Shift_Ins | novel | c.1617dupA | p.Gln540ThrfsTer7 | p.Q540Tfs*7 | Q96T17 | protein_coding | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MAP7D2 | insertion | Frame_Shift_Ins | novel | c.1524_1525insA | p.Gln509ThrfsTer18 | p.Q509Tfs*18 | Q96T17 | protein_coding | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
MAP7D2 | SNV | Missense_Mutation | c.1634N>C | p.Ile545Thr | p.I545T | Q96T17 | protein_coding | deleterious(0) | benign(0.297) | TCGA-RC-A7SH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MAP7D2 | SNV | Missense_Mutation | c.1482G>T | p.Lys494Asn | p.K494N | Q96T17 | protein_coding | tolerated(0.22) | probably_damaging(0.961) | TCGA-49-4505-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MAP7D2 | SNV | Missense_Mutation | novel | c.314A>T | p.Glu105Val | p.E105V | Q96T17 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-49-AARO-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MAP7D2 | SNV | Missense_Mutation | c.830N>T | p.Gly277Val | p.G277V | Q96T17 | protein_coding | deleterious(0.02) | benign(0.347) | TCGA-55-A492-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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