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Gene: ITGA11 |
Gene summary for ITGA11 |
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Gene information | Species | Human | Gene symbol | ITGA11 | Gene ID | 22801 |
Gene name | integrin subunit alpha 11 | |
Gene Alias | HsT18964 | |
Cytomap | 15q23 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | B3KTN6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22801 | ITGA11 | ATC11 | Human | Thyroid | ATC | 9.94e-09 | 1.02e+00 | 0.3386 |
22801 | ITGA11 | ATC12 | Human | Thyroid | ATC | 4.14e-42 | 8.45e-01 | 0.34 |
22801 | ITGA11 | ATC13 | Human | Thyroid | ATC | 3.28e-16 | 3.53e-01 | 0.34 |
22801 | ITGA11 | ATC3 | Human | Thyroid | ATC | 2.42e-14 | 9.33e-01 | 0.338 |
22801 | ITGA11 | ATC4 | Human | Thyroid | ATC | 2.05e-46 | 9.95e-01 | 0.34 |
22801 | ITGA11 | ATC5 | Human | Thyroid | ATC | 5.37e-18 | 3.92e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158928 | Thyroid | ATC | cell-substrate adhesion | 195/6293 | 363/18723 | 1.58e-15 | 1.17e-13 | 195 |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:0007160111 | Thyroid | ATC | cell-matrix adhesion | 128/6293 | 233/18723 | 1.49e-11 | 5.41e-10 | 128 |
GO:000164932 | Thyroid | ATC | osteoblast differentiation | 122/6293 | 229/18723 | 6.04e-10 | 1.60e-08 | 122 |
GO:000722919 | Thyroid | ATC | integrin-mediated signaling pathway | 63/6293 | 107/18723 | 7.09e-08 | 1.24e-06 | 63 |
GO:00336277 | Thyroid | ATC | cell adhesion mediated by integrin | 39/6293 | 72/18723 | 2.59e-04 | 1.66e-03 | 39 |
GO:000751716 | Thyroid | ATC | muscle organ development | 139/6293 | 327/18723 | 4.45e-04 | 2.64e-03 | 139 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
COL1A1 | ITGA11_ITGB1 | COL1A1_ITGA11_ITGB1 | COLLAGEN | Cervix | ADJ |
COL1A2 | ITGA11_ITGB1 | COL1A2_ITGA11_ITGB1 | COLLAGEN | Cervix | ADJ |
COL4A1 | ITGA11_ITGB1 | COL4A1_ITGA11_ITGB1 | COLLAGEN | Cervix | ADJ |
COL4A2 | ITGA11_ITGB1 | COL4A2_ITGA11_ITGB1 | COLLAGEN | Cervix | ADJ |
COL6A1 | ITGA11_ITGB1 | COL6A1_ITGA11_ITGB1 | COLLAGEN | Cervix | ADJ |
COL6A2 | ITGA11_ITGB1 | COL6A2_ITGA11_ITGB1 | COLLAGEN | Cervix | ADJ |
COL6A3 | ITGA11_ITGB1 | COL6A3_ITGA11_ITGB1 | COLLAGEN | Cervix | ADJ |
COL1A1 | ITGA11_ITGB1 | COL1A1_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL1A2 | ITGA11_ITGB1 | COL1A2_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL4A1 | ITGA11_ITGB1 | COL4A1_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL4A2 | ITGA11_ITGB1 | COL4A2_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL4A5 | ITGA11_ITGB1 | COL4A5_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL6A1 | ITGA11_ITGB1 | COL6A1_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL6A2 | ITGA11_ITGB1 | COL6A2_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL6A3 | ITGA11_ITGB1 | COL6A3_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL9A2 | ITGA11_ITGB1 | COL9A2_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL1A1 | ITGA11_ITGB1 | COL1A1_ITGA11_ITGB1 | COLLAGEN | CRC | AD |
COL1A2 | ITGA11_ITGB1 | COL1A2_ITGA11_ITGB1 | COLLAGEN | CRC | AD |
COL4A1 | ITGA11_ITGB1 | COL4A1_ITGA11_ITGB1 | COLLAGEN | CRC | AD |
COL4A2 | ITGA11_ITGB1 | COL4A2_ITGA11_ITGB1 | COLLAGEN | CRC | AD |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITGA11 | SNV | Missense_Mutation | novel | c.150N>G | p.Ile50Met | p.I50M | Q9UKX5 | protein_coding | deleterious(0.04) | possibly_damaging(0.825) | TCGA-CQ-5334-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ITGA11 | SNV | Missense_Mutation | novel | c.569N>G | p.Lys190Arg | p.K190R | Q9UKX5 | protein_coding | tolerated(0.49) | benign(0.003) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
ITGA11 | SNV | Missense_Mutation | novel | c.3257N>T | p.Gly1086Val | p.G1086V | Q9UKX5 | protein_coding | deleterious(0.03) | probably_damaging(0.964) | TCGA-CV-6936-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ITGA11 | SNV | Missense_Mutation | novel | c.2938N>A | p.Asp980Asn | p.D980N | Q9UKX5 | protein_coding | tolerated(0.32) | benign(0.006) | TCGA-CV-6940-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ITGA11 | SNV | Missense_Mutation | novel | c.3200N>T | p.Ser1067Phe | p.S1067F | Q9UKX5 | protein_coding | tolerated(0.59) | benign(0.298) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ITGA11 | SNV | Missense_Mutation | rs764776491 | c.146N>G | p.Asp49Gly | p.D49G | Q9UKX5 | protein_coding | tolerated(0.23) | benign(0.013) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ITGA11 | SNV | Missense_Mutation | rs189643766 | c.722G>A | p.Arg241Gln | p.R241Q | Q9UKX5 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-CH-5769-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
ITGA11 | SNV | Missense_Mutation | c.241N>A | p.Gly81Arg | p.G81R | Q9UKX5 | protein_coding | tolerated(0.5) | benign(0.272) | TCGA-BR-4253-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ITGA11 | SNV | Missense_Mutation | c.1883G>T | p.Gly628Val | p.G628V | Q9UKX5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ITGA11 | SNV | Missense_Mutation | rs751808335 | c.3358C>T | p.Arg1120Cys | p.R1120C | Q9UKX5 | protein_coding | deleterious(0.02) | possibly_damaging(0.634) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
22801 | ITGA11 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | IFN | 16697656 |
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