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Gene: IGFN1 |
Gene summary for IGFN1 |
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Gene information | Species | Human | Gene symbol | IGFN1 | Gene ID | 91156 |
Gene name | immunoglobulin like and fibronectin type III domain containing 1 | |
Gene Alias | EEF1A2BP1 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q86VF2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91156 | IGFN1 | PTC01 | Human | Thyroid | PTC | 7.13e-05 | 6.12e-02 | 0.1899 |
91156 | IGFN1 | PTC05 | Human | Thyroid | PTC | 8.79e-33 | 2.36e+00 | 0.2065 |
91156 | IGFN1 | PTC06 | Human | Thyroid | PTC | 1.43e-21 | 1.11e+00 | 0.2057 |
91156 | IGFN1 | ATC09 | Human | Thyroid | ATC | 4.63e-07 | 3.39e-01 | 0.2871 |
91156 | IGFN1 | ATC1 | Human | Thyroid | ATC | 3.84e-05 | 3.42e-01 | 0.2878 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034329111 | Thyroid | PTC | cell junction assembly | 180/5968 | 420/18723 | 1.17e-06 | 1.69e-05 | 180 |
GO:00508089 | Thyroid | PTC | synapse organization | 161/5968 | 426/18723 | 5.11e-03 | 2.36e-02 | 161 |
GO:003432924 | Thyroid | ATC | cell junction assembly | 187/6293 | 420/18723 | 1.71e-06 | 2.08e-05 | 187 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGFN1 | SNV | Missense_Mutation | novel | c.10441N>A | p.Leu3481Met | p.L3481M | Q86VF2 | protein_coding | tolerated(0.06) | possibly_damaging(0.587) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGFN1 | SNV | Missense_Mutation | novel | c.835N>T | p.Asp279Tyr | p.D279Y | Q86VF2 | protein_coding | deleterious(0) | unknown(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGFN1 | SNV | Missense_Mutation | c.4390N>G | p.Leu1464Val | p.L1464V | Q86VF2 | protein_coding | tolerated_low_confidence(0.16) | possibly_damaging(0.578) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IGFN1 | SNV | Missense_Mutation | novel | c.5356N>A | p.Leu1786Met | p.L1786M | Q86VF2 | protein_coding | deleterious_low_confidence(0.02) | unknown(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGFN1 | SNV | Missense_Mutation | novel | c.6623N>T | p.Ser2208Leu | p.S2208L | Q86VF2 | protein_coding | tolerated(0.19) | benign(0.138) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGFN1 | SNV | Missense_Mutation | rs781677901 | c.10270N>T | p.Arg3424Cys | p.R3424C | Q86VF2 | protein_coding | tolerated(0.07) | possibly_damaging(0.725) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGFN1 | SNV | Missense_Mutation | novel | c.3427G>A | p.Asp1143Asn | p.D1143N | Q86VF2 | protein_coding | tolerated(0.2) | possibly_damaging(0.737) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
IGFN1 | SNV | Missense_Mutation | novel | c.10859T>G | p.Leu3620Arg | p.L3620R | Q86VF2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
IGFN1 | SNV | Missense_Mutation | rs373845532 | c.3881N>T | p.Ala1294Val | p.A1294V | Q86VF2 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-AX-A06D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
IGFN1 | SNV | Missense_Mutation | novel | c.8624N>A | p.Gly2875Asp | p.G2875D | Q86VF2 | protein_coding | tolerated(0.11) | possibly_damaging(0.733) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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