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Gene: HTATSF1 |
Gene summary for HTATSF1 |
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Gene information | Species | Human | Gene symbol | HTATSF1 | Gene ID | 27336 |
Gene name | HIV-1 Tat specific factor 1 | |
Gene Alias | TAT-SF1 | |
Cytomap | Xq26.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | O43719 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27336 | HTATSF1 | LZE2T | Human | Esophagus | ESCC | 2.06e-06 | 8.49e-01 | 0.082 |
27336 | HTATSF1 | LZE4T | Human | Esophagus | ESCC | 1.38e-10 | 4.61e-01 | 0.0811 |
27336 | HTATSF1 | LZE5T | Human | Esophagus | ESCC | 9.96e-03 | 5.13e-01 | 0.0514 |
27336 | HTATSF1 | LZE7T | Human | Esophagus | ESCC | 3.64e-03 | 5.56e-01 | 0.0667 |
27336 | HTATSF1 | LZE8T | Human | Esophagus | ESCC | 2.50e-02 | 2.78e-02 | 0.067 |
27336 | HTATSF1 | LZE20T | Human | Esophagus | ESCC | 9.95e-08 | 2.83e-01 | 0.0662 |
27336 | HTATSF1 | LZE22T | Human | Esophagus | ESCC | 8.26e-03 | 4.91e-01 | 0.068 |
27336 | HTATSF1 | LZE24T | Human | Esophagus | ESCC | 7.84e-29 | 9.18e-01 | 0.0596 |
27336 | HTATSF1 | LZE21T | Human | Esophagus | ESCC | 2.87e-04 | 3.53e-01 | 0.0655 |
27336 | HTATSF1 | LZE6T | Human | Esophagus | ESCC | 2.61e-02 | 2.38e-01 | 0.0845 |
27336 | HTATSF1 | P1T-E | Human | Esophagus | ESCC | 5.94e-14 | 9.58e-01 | 0.0875 |
27336 | HTATSF1 | P2T-E | Human | Esophagus | ESCC | 7.79e-65 | 1.03e+00 | 0.1177 |
27336 | HTATSF1 | P4T-E | Human | Esophagus | ESCC | 1.88e-28 | 7.86e-01 | 0.1323 |
27336 | HTATSF1 | P5T-E | Human | Esophagus | ESCC | 2.19e-18 | 4.55e-01 | 0.1327 |
27336 | HTATSF1 | P8T-E | Human | Esophagus | ESCC | 7.16e-41 | 7.95e-01 | 0.0889 |
27336 | HTATSF1 | P9T-E | Human | Esophagus | ESCC | 1.59e-33 | 7.54e-01 | 0.1131 |
27336 | HTATSF1 | P10T-E | Human | Esophagus | ESCC | 2.78e-69 | 1.23e+00 | 0.116 |
27336 | HTATSF1 | P11T-E | Human | Esophagus | ESCC | 1.12e-16 | 7.10e-01 | 0.1426 |
27336 | HTATSF1 | P12T-E | Human | Esophagus | ESCC | 1.29e-50 | 9.63e-01 | 0.1122 |
27336 | HTATSF1 | P15T-E | Human | Esophagus | ESCC | 1.85e-23 | 5.13e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
GO:0019079111 | Esophagus | ESCC | viral genome replication | 102/8552 | 131/18723 | 4.31e-14 | 2.19e-12 | 102 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:003278412 | Esophagus | ESCC | regulation of DNA-templated transcription, elongation | 45/8552 | 53/18723 | 3.64e-09 | 7.61e-08 | 45 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:000037712 | Liver | Cirrhotic | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000039812 | Liver | Cirrhotic | mRNA splicing, via spliceosome | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:001603212 | Liver | Cirrhotic | viral process | 203/4634 | 415/18723 | 5.40e-27 | 3.76e-24 | 203 |
GO:001905812 | Liver | Cirrhotic | viral life cycle | 148/4634 | 317/18723 | 1.12e-17 | 1.64e-15 | 148 |
GO:001907912 | Liver | Cirrhotic | viral genome replication | 69/4634 | 131/18723 | 5.77e-12 | 3.98e-10 | 69 |
GO:00063544 | Liver | Cirrhotic | DNA-templated transcription, elongation | 35/4634 | 91/18723 | 2.56e-03 | 1.53e-02 | 35 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:001603222 | Liver | HCC | viral process | 286/7958 | 415/18723 | 4.41e-28 | 1.86e-25 | 286 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HTATSF1 | SNV | Missense_Mutation | c.2095G>T | p.Asp699Tyr | p.D699Y | O43719 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.885) | TCGA-49-4505-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
HTATSF1 | SNV | Missense_Mutation | c.1807G>A | p.Glu603Lys | p.E603K | O43719 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HTATSF1 | SNV | Missense_Mutation | c.1952N>A | p.Ala651Glu | p.A651E | O43719 | protein_coding | tolerated_low_confidence(0.16) | benign(0.003) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HTATSF1 | SNV | Missense_Mutation | novel | c.754N>A | p.Glu252Lys | p.E252K | O43719 | protein_coding | deleterious(0.01) | possibly_damaging(0.738) | TCGA-50-5935-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HTATSF1 | SNV | Missense_Mutation | c.1604C>T | p.Pro535Leu | p.P535L | O43719 | protein_coding | tolerated_low_confidence(0.29) | benign(0) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response | |
HTATSF1 | SNV | Missense_Mutation | c.1036G>T | p.Ala346Ser | p.A346S | O43719 | protein_coding | tolerated(0.13) | benign(0.035) | TCGA-50-6594-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
HTATSF1 | SNV | Missense_Mutation | c.1431N>T | p.Glu477Asp | p.E477D | O43719 | protein_coding | deleterious_low_confidence(0.01) | benign(0.056) | TCGA-55-8511-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HTATSF1 | SNV | Missense_Mutation | c.934G>A | p.Asp312Asn | p.D312N | O43719 | protein_coding | deleterious(0.01) | possibly_damaging(0.589) | TCGA-67-3772-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HTATSF1 | SNV | Missense_Mutation | c.1037N>G | p.Ala346Gly | p.A346G | O43719 | protein_coding | tolerated(0.1) | benign(0.125) | TCGA-67-6217-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD | |
HTATSF1 | SNV | Missense_Mutation | novel | c.272N>T | p.Asp91Val | p.D91V | O43719 | protein_coding | deleterious(0.01) | benign(0.258) | TCGA-86-8056-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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