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Gene: GRIP1 |
Gene summary for GRIP1 |
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Gene information | Species | Human | Gene symbol | GRIP1 | Gene ID | 23426 |
Gene name | glutamate receptor interacting protein 1 | |
Gene Alias | FRASRS3 | |
Cytomap | 12q14.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9Y3R0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23426 | GRIP1 | CCI_1 | Human | Cervix | CC | 4.06e-19 | 1.41e+00 | 0.528 |
23426 | GRIP1 | CCI_3 | Human | Cervix | CC | 1.85e-34 | 1.48e+00 | 0.516 |
23426 | GRIP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.36e-21 | -7.03e-01 | 0.0155 |
23426 | GRIP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.83e-15 | -7.43e-01 | -0.1808 |
23426 | GRIP1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.77e-03 | -6.16e-01 | 0.0216 |
23426 | GRIP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.85e-06 | -5.77e-01 | -0.0811 |
23426 | GRIP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.46e-09 | -6.12e-01 | -0.1088 |
23426 | GRIP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.64e-16 | -6.13e-01 | -0.1954 |
23426 | GRIP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-09 | -6.50e-01 | -0.1207 |
23426 | GRIP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.59e-09 | -7.33e-01 | -0.1526 |
23426 | GRIP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.52e-25 | -6.05e-01 | -0.1464 |
23426 | GRIP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.87e-14 | -5.80e-01 | -0.1001 |
23426 | GRIP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.68e-17 | -6.46e-01 | -0.059 |
23426 | GRIP1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.79e-02 | -5.17e-01 | -0.1706 |
23426 | GRIP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.70e-05 | -7.03e-01 | -0.2061 |
23426 | GRIP1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.59e-03 | -6.74e-01 | -0.1462 |
23426 | GRIP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.99e-05 | -5.08e-01 | -0.0842 |
23426 | GRIP1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.39e-08 | -8.14e-01 | -0.0179 |
23426 | GRIP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.30e-06 | -4.62e-01 | 0.096 |
23426 | GRIP1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.47e-03 | -6.29e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00313467 | Cervix | CC | positive regulation of cell projection organization | 72/2311 | 353/18723 | 1.04e-05 | 2.32e-04 | 72 |
GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
GO:00901509 | Cervix | CC | establishment of protein localization to membrane | 54/2311 | 260/18723 | 7.67e-05 | 1.05e-03 | 54 |
GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
GO:00619516 | Cervix | CC | establishment of protein localization to plasma membrane | 16/2311 | 60/18723 | 2.00e-03 | 1.46e-02 | 16 |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0061951 | Colorectum | AD | establishment of protein localization to plasma membrane | 31/3918 | 60/18723 | 1.37e-07 | 6.42e-06 | 31 |
GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
GO:0032456 | Colorectum | AD | endocytic recycling | 28/3918 | 73/18723 | 4.87e-04 | 5.30e-03 | 28 |
GO:0016358 | Colorectum | AD | dendrite development | 69/3918 | 243/18723 | 3.32e-03 | 2.42e-02 | 69 |
GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRIP1 | SNV | Missense_Mutation | novel | c.2087C>A | p.Thr696Asn | p.T696N | Q9Y3R0 | protein_coding | deleterious(0.02) | benign(0.26) | TCGA-CR-7386-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | PD |
GRIP1 | SNV | Missense_Mutation | novel | c.1535N>A | p.Ser512Tyr | p.S512Y | Q9Y3R0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-A45X-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GRIP1 | SNV | Missense_Mutation | novel | c.957G>T | p.Gln319His | p.Q319H | Q9Y3R0 | protein_coding | tolerated(0.15) | probably_damaging(0.967) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
GRIP1 | SNV | Missense_Mutation | novel | c.171N>A | p.Met57Ile | p.M57I | Q9Y3R0 | protein_coding | tolerated(1) | benign(0) | TCGA-UF-A7JT-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
GRIP1 | SNV | Missense_Mutation | rs200171461 | c.2636N>T | p.Ser879Leu | p.S879L | Q9Y3R0 | protein_coding | deleterious(0.04) | benign(0.021) | TCGA-EJ-5495-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD |
GRIP1 | SNV | Missense_Mutation | rs746921797 | c.1864N>A | p.Val622Met | p.V622M | Q9Y3R0 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-J4-A6G3-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Hormone Therapy | leuprolide | PD |
GRIP1 | SNV | Missense_Mutation | c.94C>T | p.Pro32Ser | p.P32S | Q9Y3R0 | protein_coding | tolerated_low_confidence(0.49) | benign(0.003) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
GRIP1 | SNV | Missense_Mutation | novel | c.1088A>G | p.Tyr363Cys | p.Y363C | Q9Y3R0 | protein_coding | tolerated(0.1) | possibly_damaging(0.818) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
GRIP1 | SNV | Missense_Mutation | novel | c.2804N>C | p.Met935Thr | p.M935T | Q9Y3R0 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-XK-AAJ3-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD |
GRIP1 | SNV | Missense_Mutation | c.2519N>T | p.Ser840Phe | p.S840F | Q9Y3R0 | protein_coding | deleterious(0.03) | probably_damaging(0.935) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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