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Gene: GRIK4 |
Gene summary for GRIK4 |
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Gene information | Species | Human | Gene symbol | GRIK4 | Gene ID | 2900 |
Gene name | glutamate ionotropic receptor kainate type subunit 4 | |
Gene Alias | EAA1 | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B2RAP6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2900 | GRIK4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.39e-03 | 1.67e-01 | -0.1808 |
2900 | GRIK4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.97e-05 | 2.30e-01 | -0.0811 |
2900 | GRIK4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.82e-02 | 8.60e-02 | -0.1954 |
2900 | GRIK4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.33e-06 | 3.88e-01 | -0.1706 |
2900 | GRIK4 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.42e-03 | 1.29e-01 | 0.096 |
2900 | GRIK4 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.01e-04 | 2.50e-01 | -0.0177 |
2900 | GRIK4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.03e-03 | 1.80e-01 | 0.0338 |
2900 | GRIK4 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.34e-02 | 2.25e-01 | 0.0112 |
2900 | GRIK4 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.02e-03 | 3.39e-01 | 0.0397 |
2900 | GRIK4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.05e-05 | 2.65e-01 | 0.3859 |
2900 | GRIK4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.40e-24 | 5.99e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRIK4 | SNV | Missense_Mutation | novel | c.554N>A | p.Ser185Tyr | p.S185Y | Q16099 | protein_coding | tolerated(1) | probably_damaging(0.95) | TCGA-85-A53L-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GRIK4 | SNV | Missense_Mutation | novel | c.1315N>A | p.Glu439Lys | p.E439K | Q16099 | protein_coding | tolerated(0.3) | benign(0.403) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GRIK4 | SNV | Missense_Mutation | novel | c.2296N>T | p.Ala766Ser | p.A766S | Q16099 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GRIK4 | SNV | Missense_Mutation | c.2383N>A | p.His795Asn | p.H795N | Q16099 | protein_coding | tolerated(0.07) | possibly_damaging(0.849) | TCGA-NC-A5HF-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
GRIK4 | insertion | Frame_Shift_Ins | novel | c.62_63insC | p.His23AlafsTer35 | p.H23Afs*35 | Q16099 | protein_coding | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
GRIK4 | SNV | Missense_Mutation | novel | c.901N>T | p.Pro301Ser | p.P301S | Q16099 | protein_coding | tolerated(0.38) | possibly_damaging(0.82) | TCGA-BA-5153-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | Xeloda | PD |
GRIK4 | SNV | Missense_Mutation | novel | c.1325A>G | p.Asp442Gly | p.D442G | Q16099 | protein_coding | deleterious(0.01) | possibly_damaging(0.735) | TCGA-CQ-5332-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
GRIK4 | SNV | Missense_Mutation | novel | c.1016N>T | p.Gln339Leu | p.Q339L | Q16099 | protein_coding | tolerated(0.14) | benign(0.007) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GRIK4 | SNV | Missense_Mutation | c.569N>A | p.Ser190Tyr | p.S190Y | Q16099 | protein_coding | tolerated(0.14) | probably_damaging(0.969) | TCGA-F7-A50G-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GRIK4 | insertion | Frame_Shift_Ins | novel | c.501_502insA | p.Ala169SerfsTer28 | p.A169Sfs*28 | Q16099 | protein_coding | TCGA-BA-4076-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | haloperidol | HALOPERIDOL | 27023437 | |
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | antagonist | CHEMBL14935 | TEZAMPANEL | |
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | antagonist | CHEMBL220492 | TOPIRAMATE | |
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | TEZAMPANEL | TEZAMPANEL | ||
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | antagonist | CHEMBL3545042 | SELURAMPANEL | |
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | antidepressants | 19924111,17671280,23394390 | ||
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | agonist | 178101000 | ||
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | agonist | 178100908 | ||
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | agonist | 178101004 | DYSIHERBAINE | |
2900 | GRIK4 | DRUGGABLE GENOME, ION CHANNEL | agonist | 178101048 |
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