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Gene: GPRIN3 |
Gene summary for GPRIN3 |
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Gene information | Species | Human | Gene symbol | GPRIN3 | Gene ID | 285513 |
Gene name | GPRIN family member 3 | |
Gene Alias | GRIN3 | |
Cytomap | 4q22.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q6ZVF9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285513 | GPRIN3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.34e-22 | -6.57e-01 | 0.0155 |
285513 | GPRIN3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.88e-10 | -6.12e-01 | -0.1808 |
285513 | GPRIN3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.23e-05 | -5.91e-01 | -0.0811 |
285513 | GPRIN3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.26e-12 | -7.38e-01 | -0.1207 |
285513 | GPRIN3 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.42e-02 | -3.43e-01 | -0.1464 |
285513 | GPRIN3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.86e-06 | -4.13e-01 | -0.1001 |
285513 | GPRIN3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.55e-04 | -4.63e-01 | -0.059 |
285513 | GPRIN3 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.06e-02 | -3.46e-01 | -0.0842 |
285513 | GPRIN3 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.19e-07 | -4.45e-01 | 0.096 |
285513 | GPRIN3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.82e-03 | -4.38e-01 | 0.0446 |
285513 | GPRIN3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.38e-03 | -5.54e-01 | 0.0528 |
285513 | GPRIN3 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.03e-03 | -5.94e-01 | -0.0177 |
285513 | GPRIN3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.39e-12 | -5.80e-01 | 0.0338 |
285513 | GPRIN3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.69e-23 | -6.56e-01 | 0.0674 |
285513 | GPRIN3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.56e-16 | -5.52e-01 | 0.294 |
285513 | GPRIN3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.35e-07 | -4.13e-01 | 0.3859 |
285513 | GPRIN3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.13e-09 | -7.36e-01 | 0.2585 |
285513 | GPRIN3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.34e-26 | -6.84e-01 | 0.3005 |
285513 | GPRIN3 | F007 | Human | Colorectum | FAP | 3.89e-03 | -4.07e-01 | 0.1176 |
285513 | GPRIN3 | A001-C-207 | Human | Colorectum | FAP | 1.33e-02 | -2.34e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPRIN3 | SNV | Missense_Mutation | novel | c.397C>T | p.His133Tyr | p.H133Y | Q6ZVF9 | protein_coding | tolerated(0.27) | benign(0.01) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GPRIN3 | insertion | In_Frame_Ins | novel | c.992_993insCAG | p.Ser330dup | p.S330dup | Q6ZVF9 | protein_coding | TCGA-CN-6018-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GPRIN3 | insertion | Nonsense_Mutation | novel | c.2163_2164insTGAATACCGT | p.Lys722Ter | p.K722* | Q6ZVF9 | protein_coding | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
GPRIN3 | SNV | Missense_Mutation | c.1097G>A | p.Gly366Glu | p.G366E | Q6ZVF9 | protein_coding | deleterious(0.01) | benign(0.078) | TCGA-CH-5762-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
GPRIN3 | SNV | Missense_Mutation | c.2105N>G | p.Ala702Gly | p.A702G | Q6ZVF9 | protein_coding | deleterious(0.01) | benign(0.062) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |
GPRIN3 | SNV | Missense_Mutation | c.794C>A | p.Pro265His | p.P265H | Q6ZVF9 | protein_coding | deleterious(0) | benign(0.11) | TCGA-BR-4191-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | SD | |
GPRIN3 | SNV | Missense_Mutation | c.1124G>A | p.Ser375Asn | p.S375N | Q6ZVF9 | protein_coding | tolerated(0.55) | benign(0.006) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GPRIN3 | SNV | Missense_Mutation | c.484T>C | p.Ser162Pro | p.S162P | Q6ZVF9 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-BR-A4CS-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GPRIN3 | SNV | Missense_Mutation | c.548N>C | p.Asp183Ala | p.D183A | Q6ZVF9 | protein_coding | tolerated(0.31) | benign(0.025) | TCGA-CD-8529-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | epirubicin | CR | |
GPRIN3 | SNV | Missense_Mutation | rs368769094 | c.2248N>T | p.His750Tyr | p.H750Y | Q6ZVF9 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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