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Gene: FER |
Gene summary for FER |
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Gene information | Species | Human | Gene symbol | FER | Gene ID | 2241 |
Gene name | FER tyrosine kinase | |
Gene Alias | PPP1R74 | |
Cytomap | 5q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P16591 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2241 | FER | CA_HPV_1 | Human | Cervix | CC | 2.15e-03 | -1.29e-01 | 0.0264 |
2241 | FER | CCI_2 | Human | Cervix | CC | 5.72e-03 | 5.68e-01 | 0.5249 |
2241 | FER | CCI_3 | Human | Cervix | CC | 6.13e-11 | 9.61e-01 | 0.516 |
2241 | FER | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.33e-10 | -5.43e-01 | 0.0155 |
2241 | FER | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.49e-03 | -4.81e-01 | -0.1808 |
2241 | FER | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.73e-05 | -5.76e-01 | -0.1207 |
2241 | FER | HTA11_696_2000001011 | Human | Colorectum | AD | 4.13e-13 | -3.96e-01 | -0.1464 |
2241 | FER | HTA11_866_2000001011 | Human | Colorectum | AD | 1.85e-02 | -2.90e-01 | -0.1001 |
2241 | FER | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.50e-06 | -4.30e-01 | -0.059 |
2241 | FER | HTA11_866_3004761011 | Human | Colorectum | AD | 2.27e-10 | -5.74e-01 | 0.096 |
2241 | FER | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.93e-03 | -4.73e-01 | 0.0338 |
2241 | FER | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.30e-10 | -4.43e-01 | 0.0674 |
2241 | FER | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.12e-08 | -4.37e-01 | 0.294 |
2241 | FER | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.46e-07 | -4.47e-01 | 0.3859 |
2241 | FER | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.15e-24 | -6.43e-01 | 0.3005 |
2241 | FER | A001-C-207 | Human | Colorectum | FAP | 9.59e-04 | -3.63e-01 | 0.1278 |
2241 | FER | A015-C-203 | Human | Colorectum | FAP | 1.76e-21 | -5.36e-01 | -0.1294 |
2241 | FER | A015-C-204 | Human | Colorectum | FAP | 4.08e-06 | -3.63e-01 | -0.0228 |
2241 | FER | A014-C-040 | Human | Colorectum | FAP | 3.21e-03 | -3.78e-01 | -0.1184 |
2241 | FER | A002-C-201 | Human | Colorectum | FAP | 4.97e-12 | -4.61e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:000697910 | Cervix | CC | response to oxidative stress | 102/2311 | 446/18723 | 2.99e-10 | 4.36e-08 | 102 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045203 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045205 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045208 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa045209 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa0452010 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452011 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452025 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa04520111 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa0452026 | Endometrium | EEC | Adherens junction | 36/1237 | 93/8465 | 8.57e-09 | 1.48e-07 | 1.11e-07 | 36 |
hsa0452035 | Endometrium | EEC | Adherens junction | 36/1237 | 93/8465 | 8.57e-09 | 1.48e-07 | 1.11e-07 | 36 |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0452014 | Liver | NAFLD | Adherens junction | 37/1043 | 93/8465 | 1.50e-11 | 1.64e-09 | 1.32e-09 | 37 |
hsa0452015 | Liver | NAFLD | Adherens junction | 37/1043 | 93/8465 | 1.50e-11 | 1.64e-09 | 1.32e-09 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FER | SNV | Missense_Mutation | c.1796N>G | p.Gln599Arg | p.Q599R | P16591 | protein_coding | tolerated(0.1) | benign(0.011) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FER | SNV | Missense_Mutation | c.1613N>C | p.Ile538Thr | p.I538T | P16591 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
FER | SNV | Missense_Mutation | novel | c.2300N>G | p.Gln767Arg | p.Q767R | P16591 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-IN-A6RL-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
FER | SNV | Missense_Mutation | novel | c.1127N>G | p.Lys376Arg | p.K376R | P16591 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-VQ-A927-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
FER | deletion | Frame_Shift_Del | novel | c.931delA | p.Thr311ArgfsTer2 | p.T311Rfs*2 | P16591 | protein_coding | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
FER | insertion | Nonsense_Mutation | novel | c.2240_2241insTAATGTCATAGTATAA | p.Ile748AsnfsTer5 | p.I748Nfs*5 | P16591 | protein_coding | TCGA-E8-A419-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FER | insertion | Nonsense_Mutation | novel | c.2240_2241insTAATGTCATAGTATAA | p.Ile748AsnfsTer5 | p.I748Nfs*5 | P16591 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
FER | insertion | Frame_Shift_Ins | novel | c.1500_1501insGATCATAT | p.Gln501AspfsTer31 | p.Q501Dfs*31 | P16591 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
FER | insertion | Frame_Shift_Ins | novel | c.113_114insGAAATTAGTC | p.Ser38ArgfsTer5 | p.S38Rfs*5 | P16591 | protein_coding | TCGA-EL-A3ZQ-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FER | insertion | Nonsense_Mutation | novel | c.2240_2241insTAATGTCATAGTATAACA | p.Gly747_Ile748insAsnValIleValTerHis | p.G747_I748insNVIV*H | P16591 | protein_coding | TCGA-ET-A40S-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 328083505 | ||
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | ALISERTIB | ALISERTIB | ||
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 249565817 | ||
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | TAMATINIB | R-406 | ||
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | CENISERTIB | CENISERTIB | ||
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | CYC-116 | CYC-116 | ||
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | LINIFANIB | LINIFANIB | ||
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | ENTRECTINIB | ENTRECTINIB | ||
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
2241 | FER | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | CEDIRANIB | CEDIRANIB |
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