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Gene: FCHO1 |
Gene summary for FCHO1 |
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Gene information | Species | Human | Gene symbol | FCHO1 | Gene ID | 23149 |
Gene name | FCH and mu domain containing endocytic adaptor 1 | |
Gene Alias | IMD76 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A0C3SFZ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23149 | FCHO1 | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 2.80e-01 | 0.068 |
23149 | FCHO1 | P5T-E | Human | Esophagus | ESCC | 2.56e-16 | 3.05e-01 | 0.1327 |
23149 | FCHO1 | P8T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.67e-01 | 0.0889 |
23149 | FCHO1 | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 3.49e-01 | 0.1426 |
23149 | FCHO1 | P26T-E | Human | Esophagus | ESCC | 2.06e-08 | 2.37e-01 | 0.1276 |
23149 | FCHO1 | P37T-E | Human | Esophagus | ESCC | 4.58e-09 | 2.42e-01 | 0.1371 |
23149 | FCHO1 | P49T-E | Human | Esophagus | ESCC | 1.53e-21 | 1.46e+00 | 0.1768 |
23149 | FCHO1 | P52T-E | Human | Esophagus | ESCC | 1.88e-11 | 3.06e-01 | 0.1555 |
23149 | FCHO1 | P74T-E | Human | Esophagus | ESCC | 1.26e-08 | 2.76e-01 | 0.1479 |
23149 | FCHO1 | P76T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.32e-01 | 0.1207 |
23149 | FCHO1 | P82T-E | Human | Esophagus | ESCC | 9.44e-05 | 2.44e-01 | 0.1072 |
23149 | FCHO1 | P107T-E | Human | Esophagus | ESCC | 1.21e-05 | 1.82e-01 | 0.171 |
23149 | FCHO1 | P128T-E | Human | Esophagus | ESCC | 1.37e-04 | 1.81e-01 | 0.1241 |
23149 | FCHO1 | P130T-E | Human | Esophagus | ESCC | 9.78e-30 | 5.99e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
GO:007258314 | Esophagus | ESCC | clathrin-dependent endocytosis | 34/8552 | 47/18723 | 1.91e-04 | 1.21e-03 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FCHO1 | insertion | Frame_Shift_Ins | novel | c.1243_1244insC | p.Arg417GlnfsTer29 | p.R417Qfs*29 | protein_coding | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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