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Gene: FAM171A1 |
Gene summary for FAM171A1 |
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Gene information | Species | Human | Gene symbol | FAM171A1 | Gene ID | 221061 |
Gene name | family with sequence similarity 171 member A1 | |
Gene Alias | APCN | |
Cytomap | 10p13 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | B3KMX9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221061 | FAM171A1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.72e-10 | -5.15e-01 | 0.0155 |
221061 | FAM171A1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.45e-03 | -5.12e-01 | -0.1207 |
221061 | FAM171A1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.14e-22 | -6.38e-01 | 0.3005 |
221061 | FAM171A1 | F007 | Human | Colorectum | FAP | 1.27e-06 | -5.01e-01 | 0.1176 |
221061 | FAM171A1 | A002-C-010 | Human | Colorectum | FAP | 1.15e-12 | -3.64e-01 | 0.242 |
221061 | FAM171A1 | A001-C-207 | Human | Colorectum | FAP | 3.04e-06 | -3.59e-01 | 0.1278 |
221061 | FAM171A1 | A015-C-203 | Human | Colorectum | FAP | 2.56e-39 | -5.28e-01 | -0.1294 |
221061 | FAM171A1 | A015-C-204 | Human | Colorectum | FAP | 1.16e-08 | -4.57e-01 | -0.0228 |
221061 | FAM171A1 | A014-C-040 | Human | Colorectum | FAP | 5.17e-04 | -2.11e-01 | -0.1184 |
221061 | FAM171A1 | A002-C-201 | Human | Colorectum | FAP | 3.82e-23 | -6.08e-01 | 0.0324 |
221061 | FAM171A1 | A002-C-203 | Human | Colorectum | FAP | 2.80e-16 | -5.28e-01 | 0.2786 |
221061 | FAM171A1 | A001-C-119 | Human | Colorectum | FAP | 2.94e-08 | -4.33e-01 | -0.1557 |
221061 | FAM171A1 | A001-C-108 | Human | Colorectum | FAP | 3.49e-26 | -5.10e-01 | -0.0272 |
221061 | FAM171A1 | A002-C-205 | Human | Colorectum | FAP | 5.82e-28 | -6.26e-01 | -0.1236 |
221061 | FAM171A1 | A001-C-104 | Human | Colorectum | FAP | 1.00e-06 | -2.95e-01 | 0.0184 |
221061 | FAM171A1 | A015-C-005 | Human | Colorectum | FAP | 1.33e-08 | -4.59e-01 | -0.0336 |
221061 | FAM171A1 | A015-C-006 | Human | Colorectum | FAP | 1.08e-20 | -5.18e-01 | -0.0994 |
221061 | FAM171A1 | A015-C-106 | Human | Colorectum | FAP | 7.43e-13 | -3.21e-01 | -0.0511 |
221061 | FAM171A1 | A002-C-114 | Human | Colorectum | FAP | 2.66e-22 | -5.20e-01 | -0.1561 |
221061 | FAM171A1 | A015-C-104 | Human | Colorectum | FAP | 1.05e-42 | -5.99e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0061572 | Colorectum | AD | actin filament bundle organization | 60/3918 | 161/18723 | 1.33e-06 | 4.23e-05 | 60 |
GO:0051017 | Colorectum | AD | actin filament bundle assembly | 58/3918 | 157/18723 | 2.74e-06 | 7.89e-05 | 58 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0031032 | Colorectum | AD | actomyosin structure organization | 65/3918 | 196/18723 | 4.17e-05 | 7.37e-04 | 65 |
GO:0030038 | Colorectum | AD | contractile actin filament bundle assembly | 39/3918 | 106/18723 | 1.22e-04 | 1.78e-03 | 39 |
GO:0043149 | Colorectum | AD | stress fiber assembly | 39/3918 | 106/18723 | 1.22e-04 | 1.78e-03 | 39 |
GO:00070152 | Colorectum | MSS | actin filament organization | 146/3467 | 442/18723 | 1.16e-13 | 2.67e-11 | 146 |
GO:00226042 | Colorectum | MSS | regulation of cell morphogenesis | 103/3467 | 309/18723 | 2.70e-10 | 2.56e-08 | 103 |
GO:00083602 | Colorectum | MSS | regulation of cell shape | 52/3467 | 154/18723 | 4.40e-06 | 1.24e-04 | 52 |
GO:00615722 | Colorectum | MSS | actin filament bundle organization | 50/3467 | 161/18723 | 8.18e-05 | 1.35e-03 | 50 |
GO:00510172 | Colorectum | MSS | actin filament bundle assembly | 49/3467 | 157/18723 | 8.35e-05 | 1.36e-03 | 49 |
GO:00310322 | Colorectum | MSS | actomyosin structure organization | 53/3467 | 196/18723 | 2.04e-03 | 1.75e-02 | 53 |
GO:00300382 | Colorectum | MSS | contractile actin filament bundle assembly | 32/3467 | 106/18723 | 2.41e-03 | 1.96e-02 | 32 |
GO:00431492 | Colorectum | MSS | stress fiber assembly | 32/3467 | 106/18723 | 2.41e-03 | 1.96e-02 | 32 |
GO:00070154 | Colorectum | FAP | actin filament organization | 125/2622 | 442/18723 | 1.97e-15 | 3.03e-12 | 125 |
GO:00226044 | Colorectum | FAP | regulation of cell morphogenesis | 87/2622 | 309/18723 | 4.89e-11 | 1.87e-08 | 87 |
GO:00615723 | Colorectum | FAP | actin filament bundle organization | 49/2622 | 161/18723 | 5.69e-08 | 4.30e-06 | 49 |
GO:00510173 | Colorectum | FAP | actin filament bundle assembly | 48/2622 | 157/18723 | 6.62e-08 | 4.56e-06 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM171A1 | SNV | Missense_Mutation | rs757735986 | c.695N>T | p.Thr232Met | p.T232M | Q5VUB5 | protein_coding | tolerated(0.08) | benign(0.05) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM171A1 | SNV | Missense_Mutation | rs761474858 | c.284A>G | p.Tyr95Cys | p.Y95C | Q5VUB5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FAM171A1 | SNV | Missense_Mutation | c.1613A>G | p.Glu538Gly | p.E538G | Q5VUB5 | protein_coding | deleterious(0.04) | benign(0.13) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM171A1 | SNV | Missense_Mutation | c.922N>A | p.Ala308Thr | p.A308T | Q5VUB5 | protein_coding | tolerated(0.6) | benign(0.282) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
FAM171A1 | SNV | Missense_Mutation | c.2078T>C | p.Leu693Pro | p.L693P | Q5VUB5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FAM171A1 | SNV | Missense_Mutation | rs758560184 | c.2524N>A | p.Ala842Thr | p.A842T | Q5VUB5 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
FAM171A1 | SNV | Missense_Mutation | c.2228N>T | p.Gly743Val | p.G743V | Q5VUB5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
FAM171A1 | SNV | Missense_Mutation | c.2102N>T | p.Pro701Leu | p.P701L | Q5VUB5 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
FAM171A1 | SNV | Missense_Mutation | rs775763401 | c.736N>T | p.Arg246Trp | p.R246W | Q5VUB5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM171A1 | SNV | Missense_Mutation | c.2666N>A | p.Ile889Asn | p.I889N | Q5VUB5 | protein_coding | deleterious(0) | benign(0.216) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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