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Gene: EP400 |
Gene summary for EP400 |
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Gene information | Species | Human | Gene symbol | EP400 | Gene ID | 57634 |
Gene name | E1A binding protein p400 | |
Gene Alias | CAGH32 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96L91 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57634 | EP400 | LZE4T | Human | Esophagus | ESCC | 1.73e-10 | 2.20e-01 | 0.0811 |
57634 | EP400 | LZE7T | Human | Esophagus | ESCC | 6.05e-14 | 6.31e-01 | 0.0667 |
57634 | EP400 | LZE20T | Human | Esophagus | ESCC | 8.42e-09 | 1.56e-01 | 0.0662 |
57634 | EP400 | LZE24T | Human | Esophagus | ESCC | 4.95e-18 | 3.68e-01 | 0.0596 |
57634 | EP400 | LZE21T | Human | Esophagus | ESCC | 4.46e-09 | 3.24e-01 | 0.0655 |
57634 | EP400 | P1T-E | Human | Esophagus | ESCC | 2.28e-14 | 4.22e-01 | 0.0875 |
57634 | EP400 | P2T-E | Human | Esophagus | ESCC | 1.38e-47 | 8.30e-01 | 0.1177 |
57634 | EP400 | P4T-E | Human | Esophagus | ESCC | 7.30e-19 | 2.81e-01 | 0.1323 |
57634 | EP400 | P5T-E | Human | Esophagus | ESCC | 7.78e-14 | 2.20e-01 | 0.1327 |
57634 | EP400 | P8T-E | Human | Esophagus | ESCC | 1.18e-21 | 3.74e-01 | 0.0889 |
57634 | EP400 | P9T-E | Human | Esophagus | ESCC | 1.30e-15 | 1.80e-01 | 0.1131 |
57634 | EP400 | P10T-E | Human | Esophagus | ESCC | 1.66e-20 | 3.09e-01 | 0.116 |
57634 | EP400 | P11T-E | Human | Esophagus | ESCC | 1.75e-16 | 6.11e-01 | 0.1426 |
57634 | EP400 | P12T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.28e-01 | 0.1122 |
57634 | EP400 | P15T-E | Human | Esophagus | ESCC | 2.57e-20 | 3.88e-01 | 0.1149 |
57634 | EP400 | P16T-E | Human | Esophagus | ESCC | 1.91e-23 | 3.72e-01 | 0.1153 |
57634 | EP400 | P17T-E | Human | Esophagus | ESCC | 1.52e-10 | 2.28e-01 | 0.1278 |
57634 | EP400 | P20T-E | Human | Esophagus | ESCC | 1.80e-23 | 4.72e-01 | 0.1124 |
57634 | EP400 | P21T-E | Human | Esophagus | ESCC | 1.99e-21 | 3.80e-01 | 0.1617 |
57634 | EP400 | P22T-E | Human | Esophagus | ESCC | 8.98e-12 | 2.46e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:004396712 | Esophagus | ESCC | histone H4 acetylation | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:00439682 | Esophagus | ESCC | histone H2A acetylation | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
GO:00182052 | Liver | HCC | peptidyl-lysine modification | 230/7958 | 376/18723 | 1.51e-13 | 8.32e-12 | 230 |
GO:00064732 | Liver | HCC | protein acetylation | 135/7958 | 201/18723 | 1.20e-12 | 5.92e-11 | 135 |
GO:00435432 | Liver | HCC | protein acylation | 157/7958 | 243/18723 | 2.40e-12 | 1.12e-10 | 157 |
GO:00183942 | Liver | HCC | peptidyl-lysine acetylation | 116/7958 | 169/18723 | 5.11e-12 | 2.23e-10 | 116 |
GO:00064752 | Liver | HCC | internal protein amino acid acetylation | 107/7958 | 160/18723 | 3.77e-10 | 1.23e-08 | 107 |
GO:00183932 | Liver | HCC | internal peptidyl-lysine acetylation | 105/7958 | 158/18723 | 9.48e-10 | 2.90e-08 | 105 |
GO:00165732 | Liver | HCC | histone acetylation | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:00439671 | Liver | HCC | histone H4 acetylation | 50/7958 | 67/18723 | 9.14e-08 | 1.82e-06 | 50 |
GO:00439681 | Liver | HCC | histone H2A acetylation | 14/7958 | 17/18723 | 9.39e-04 | 5.47e-03 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EP400 | SNV | Missense_Mutation | rs760596309 | c.2429N>A | p.Arg810His | p.R810H | Q96L91 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EP400 | SNV | Missense_Mutation | rs377249323 | c.2659N>A | p.Ala887Thr | p.A887T | Q96L91 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EP400 | SNV | Missense_Mutation | c.4873N>A | p.Val1625Met | p.V1625M | Q96L91 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EP400 | SNV | Missense_Mutation | c.7085N>T | p.Thr2362Ile | p.T2362I | Q96L91 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EP400 | SNV | Missense_Mutation | c.8595N>A | p.Met2865Ile | p.M2865I | Q96L91 | protein_coding | tolerated_low_confidence(0.85) | benign(0.003) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EP400 | SNV | Missense_Mutation | rs368167632 | c.2285G>A | p.Arg762His | p.R762H | Q96L91 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
EP400 | SNV | Missense_Mutation | c.5824A>G | p.Thr1942Ala | p.T1942A | Q96L91 | protein_coding | tolerated(0.41) | benign(0.006) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EP400 | SNV | Missense_Mutation | c.5935G>T | p.Asp1979Tyr | p.D1979Y | Q96L91 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EP400 | SNV | Missense_Mutation | c.6877C>T | p.Arg2293Cys | p.R2293C | Q96L91 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EP400 | SNV | Missense_Mutation | c.2766N>T | p.Glu922Asp | p.E922D | Q96L91 | protein_coding | deleterious(0.05) | probably_damaging(0.945) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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