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Gene: COBLL1 |
Gene summary for COBLL1 |
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Gene information | Species | Human | Gene symbol | COBLL1 | Gene ID | 22837 |
Gene name | cordon-bleu WH2 repeat protein like 1 | |
Gene Alias | COBLR1 | |
Cytomap | 2q24.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A0D9SG04 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22837 | COBLL1 | CCI_1 | Human | Cervix | CC | 8.98e-09 | 1.24e+00 | 0.528 |
22837 | COBLL1 | CCI_2 | Human | Cervix | CC | 9.69e-10 | 1.56e+00 | 0.5249 |
22837 | COBLL1 | CCI_3 | Human | Cervix | CC | 1.31e-21 | 1.61e+00 | 0.516 |
22837 | COBLL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.35e-09 | -4.43e-01 | 0.0155 |
22837 | COBLL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.21e-07 | -3.72e-01 | -0.1464 |
22837 | COBLL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.50e-04 | -3.21e-01 | -0.1001 |
22837 | COBLL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.06e-07 | -4.38e-01 | 0.096 |
22837 | COBLL1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.65e-04 | -4.67e-01 | 0.0338 |
22837 | COBLL1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.90e-06 | -3.17e-01 | 0.0674 |
22837 | COBLL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.98e-12 | -3.94e-01 | 0.294 |
22837 | COBLL1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.24e-03 | -4.97e-01 | 0.2585 |
22837 | COBLL1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.92e-06 | -3.03e-01 | 0.3005 |
22837 | COBLL1 | F007 | Human | Colorectum | FAP | 5.74e-05 | -3.90e-01 | 0.1176 |
22837 | COBLL1 | A002-C-010 | Human | Colorectum | FAP | 1.72e-02 | -1.59e-01 | 0.242 |
22837 | COBLL1 | A001-C-207 | Human | Colorectum | FAP | 8.57e-05 | -3.35e-01 | 0.1278 |
22837 | COBLL1 | A015-C-203 | Human | Colorectum | FAP | 8.02e-28 | -4.12e-01 | -0.1294 |
22837 | COBLL1 | A015-C-204 | Human | Colorectum | FAP | 2.23e-09 | -4.39e-01 | -0.0228 |
22837 | COBLL1 | A014-C-040 | Human | Colorectum | FAP | 1.91e-02 | -2.59e-01 | -0.1184 |
22837 | COBLL1 | A002-C-201 | Human | Colorectum | FAP | 2.30e-14 | -4.18e-01 | 0.0324 |
22837 | COBLL1 | A002-C-203 | Human | Colorectum | FAP | 7.26e-05 | -1.83e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COBLL1 | SNV | Missense_Mutation | novel | c.2024C>G | p.Thr675Ser | p.T675S | protein_coding | tolerated(0.2) | benign(0.124) | TCGA-CN-A49B-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
COBLL1 | SNV | Missense_Mutation | novel | c.1676C>G | p.Thr559Arg | p.T559R | protein_coding | deleterious(0) | possibly_damaging(0.73) | TCGA-CV-7407-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COBLL1 | SNV | Missense_Mutation | novel | c.468N>T | p.Leu156Phe | p.L156F | protein_coding | deleterious(0.01) | benign(0.16) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
COBLL1 | SNV | Missense_Mutation | novel | c.2366N>T | p.Asp789Val | p.D789V | protein_coding | tolerated(0.51) | benign(0.187) | TCGA-WA-A7H4-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
COBLL1 | insertion | Frame_Shift_Ins | novel | c.1952_1953insTACA | p.Glu652ThrfsTer8 | p.E652Tfs*8 | protein_coding | TCGA-CV-A45T-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
COBLL1 | SNV | Missense_Mutation | c.2255N>T | p.Ser752Leu | p.S752L | protein_coding | tolerated(0.49) | benign(0.001) | TCGA-VP-A87H-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | ||
COBLL1 | SNV | Missense_Mutation | c.3306N>T | p.Gln1102His | p.Q1102H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | ||
COBLL1 | SNV | Missense_Mutation | rs181143305 | c.2332N>A | p.Val778Ile | p.V778I | protein_coding | tolerated(1) | benign(0) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
COBLL1 | SNV | Missense_Mutation | rs557248063 | c.3587N>T | p.Ser1196Leu | p.S1196L | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
COBLL1 | SNV | Missense_Mutation | novel | c.3386N>A | p.Thr1129Asn | p.T1129N | protein_coding | tolerated(0.43) | benign(0.012) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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