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Gene: CNGB1 |
Gene summary for CNGB1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CNGB1 | Gene ID | 1258 |
Gene name | cyclic nucleotide gated channel subunit beta 1 | |
Gene Alias | CNCG2 | |
Cytomap | 16q21 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q14028 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1258 | CNGB1 | C04 | Human | Oral cavity | OSCC | 2.02e-04 | 2.00e-01 | 0.2633 |
1258 | CNGB1 | C21 | Human | Oral cavity | OSCC | 8.63e-03 | 1.16e-01 | 0.2678 |
1258 | CNGB1 | C51 | Human | Oral cavity | OSCC | 3.74e-18 | 6.08e-01 | 0.2674 |
1258 | CNGB1 | C06 | Human | Oral cavity | OSCC | 5.31e-08 | 1.03e+00 | 0.2699 |
1258 | CNGB1 | C09 | Human | Oral cavity | OSCC | 1.83e-17 | 4.24e-01 | 0.1431 |
1258 | CNGB1 | SYSMH3 | Human | Oral cavity | OSCC | 4.88e-03 | 1.59e-01 | 0.2442 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | EOLP: Erosive Oral lichen planus | |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000931416 | Oral cavity | OSCC | response to radiation | 241/7305 | 456/18723 | 9.76e-10 | 2.40e-08 | 241 |
GO:00094164 | Oral cavity | OSCC | response to light stimulus | 159/7305 | 320/18723 | 5.98e-05 | 4.92e-04 | 159 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNGB1 | SNV | Missense_Mutation | rs199660047 | c.3331G>A | p.Ala1111Thr | p.A1111T | Q14028 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-FI-A2D2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatinum | PD |
CNGB1 | SNV | Missense_Mutation | novel | c.3647N>T | p.Ala1216Val | p.A1216V | Q14028 | protein_coding | tolerated(0.07) | benign(0.051) | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CNGB1 | SNV | Missense_Mutation | rs772006490 | c.166G>A | p.Glu56Lys | p.E56K | Q14028 | protein_coding | tolerated_low_confidence(0.07) | possibly_damaging(0.695) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CNGB1 | insertion | Frame_Shift_Ins | novel | c.428_429insAGCCCGCCCTCAACTTCCCCTAGCT | p.Asn144AlafsTer10 | p.N144Afs*10 | Q14028 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CNGB1 | deletion | Frame_Shift_Del | novel | c.1435delC | p.Leu479SerfsTer24 | p.L479Sfs*24 | Q14028 | protein_coding | TCGA-AP-A1DR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
CNGB1 | insertion | Frame_Shift_Ins | novel | c.428_429insTCAACTTCCCCTAGCT | p.Asn144GlnfsTer7 | p.N144Qfs*7 | Q14028 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
CNGB1 | insertion | Frame_Shift_Ins | novel | c.428_429insTTCCCCTAGCT | p.Asn144SerfsTer137 | p.N144Sfs*137 | Q14028 | protein_coding | TCGA-BG-A0MS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
CNGB1 | insertion | Frame_Shift_Ins | novel | c.428_429insGCCCTCAACTTCCCCTAGCT | p.Asn144ProfsTer140 | p.N144Pfs*140 | Q14028 | protein_coding | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CNGB1 | insertion | Frame_Shift_Ins | novel | c.428_429insAGCCCGCCCTCAACTTCCCCTAGCT | p.Asn144AlafsTer10 | p.N144Afs*10 | Q14028 | protein_coding | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CNGB1 | SNV | Missense_Mutation | novel | c.2707N>C | p.Tyr903His | p.Y903H | Q14028 | protein_coding | deleterious(0) | possibly_damaging(0.686) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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