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Gene: CLSTN2 |
Gene summary for CLSTN2 |
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Gene information | Species | Human | Gene symbol | CLSTN2 | Gene ID | 64084 |
Gene name | calsyntenin 2 | |
Gene Alias | ALC-GAMMA | |
Cytomap | 3q23 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9H4D0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64084 | CLSTN2 | S014 | Human | Liver | HCC | 6.80e-12 | 5.15e-01 | 0.2254 |
64084 | CLSTN2 | S015 | Human | Liver | HCC | 9.93e-07 | 4.33e-01 | 0.2375 |
64084 | CLSTN2 | S016 | Human | Liver | HCC | 1.36e-20 | 5.89e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLSTN2 | SNV | Missense_Mutation | novel | c.2213G>T | p.Gly738Val | p.G738V | Q9H4D0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MN-A4N1-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CLSTN2 | SNV | Missense_Mutation | rs776372790 | c.2357N>C | p.Glu786Ala | p.E786A | Q9H4D0 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-18-3414-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CLSTN2 | SNV | Missense_Mutation | novel | c.1171C>A | p.Pro391Thr | p.P391T | Q9H4D0 | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
CLSTN2 | SNV | Missense_Mutation | rs753704000 | c.2519N>T | p.Ser840Phe | p.S840F | Q9H4D0 | protein_coding | deleterious(0) | benign(0.133) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CLSTN2 | SNV | Missense_Mutation | rs762229815 | c.1858N>A | p.Glu620Lys | p.E620K | Q9H4D0 | protein_coding | tolerated(0.11) | benign(0.058) | TCGA-21-1082-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CLSTN2 | SNV | Missense_Mutation | novel | c.2026N>A | p.Asp676Asn | p.D676N | Q9H4D0 | protein_coding | tolerated(0.12) | benign(0) | TCGA-22-1000-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CLSTN2 | SNV | Missense_Mutation | c.1882N>A | p.Leu628Ile | p.L628I | Q9H4D0 | protein_coding | deleterious(0) | benign(0.051) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
CLSTN2 | SNV | Missense_Mutation | c.2660N>A | p.Pro887His | p.P887H | Q9H4D0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CLSTN2 | SNV | Missense_Mutation | c.2781N>T | p.Glu927Asp | p.E927D | Q9H4D0 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-39-5011-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD | |
CLSTN2 | SNV | Missense_Mutation | c.2113N>T | p.Asp705Tyr | p.D705Y | Q9H4D0 | protein_coding | deleterious(0) | possibly_damaging(0.459) | TCGA-43-3394-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | gemzar | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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