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Gene: CLCN3 |
Gene summary for CLCN3 |
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Gene information | Species | Human | Gene symbol | CLCN3 | Gene ID | 1182 |
Gene name | chloride voltage-gated channel 3 | |
Gene Alias | CLC3 | |
Cytomap | 4q33 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | P51790 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1182 | CLCN3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.17e-06 | -3.97e-01 | 0.0155 |
1182 | CLCN3 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.21e-03 | 3.35e-01 | -0.1954 |
1182 | CLCN3 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.40e-04 | -3.11e-01 | -0.1001 |
1182 | CLCN3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.42e-04 | -3.38e-01 | 0.3005 |
1182 | CLCN3 | A015-C-203 | Human | Colorectum | FAP | 3.87e-24 | -5.05e-01 | -0.1294 |
1182 | CLCN3 | A015-C-204 | Human | Colorectum | FAP | 4.40e-07 | -2.95e-01 | -0.0228 |
1182 | CLCN3 | A002-C-201 | Human | Colorectum | FAP | 5.90e-08 | -2.28e-01 | 0.0324 |
1182 | CLCN3 | A001-C-119 | Human | Colorectum | FAP | 2.48e-07 | -3.55e-01 | -0.1557 |
1182 | CLCN3 | A001-C-108 | Human | Colorectum | FAP | 1.94e-09 | -1.91e-01 | -0.0272 |
1182 | CLCN3 | A002-C-205 | Human | Colorectum | FAP | 7.35e-15 | -2.81e-01 | -0.1236 |
1182 | CLCN3 | A015-C-006 | Human | Colorectum | FAP | 9.90e-13 | -4.73e-01 | -0.0994 |
1182 | CLCN3 | A015-C-106 | Human | Colorectum | FAP | 3.57e-08 | -1.93e-01 | -0.0511 |
1182 | CLCN3 | A002-C-114 | Human | Colorectum | FAP | 1.11e-13 | -3.72e-01 | -0.1561 |
1182 | CLCN3 | A015-C-104 | Human | Colorectum | FAP | 3.02e-22 | -4.39e-01 | -0.1899 |
1182 | CLCN3 | A001-C-014 | Human | Colorectum | FAP | 2.60e-10 | -1.33e-01 | 0.0135 |
1182 | CLCN3 | A002-C-016 | Human | Colorectum | FAP | 2.23e-15 | -1.84e-01 | 0.0521 |
1182 | CLCN3 | A015-C-002 | Human | Colorectum | FAP | 2.11e-10 | -5.13e-01 | -0.0763 |
1182 | CLCN3 | A001-C-203 | Human | Colorectum | FAP | 4.05e-06 | -1.56e-01 | -0.0481 |
1182 | CLCN3 | A002-C-116 | Human | Colorectum | FAP | 1.25e-26 | -2.64e-01 | -0.0452 |
1182 | CLCN3 | A014-C-008 | Human | Colorectum | FAP | 3.37e-09 | -3.72e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902600 | Colorectum | AD | proton transmembrane transport | 66/3918 | 157/18723 | 1.59e-09 | 1.17e-07 | 66 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0007032 | Colorectum | AD | endosome organization | 33/3918 | 82/18723 | 5.30e-05 | 9.01e-04 | 33 |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:0072593 | Colorectum | AD | reactive oxygen species metabolic process | 73/3918 | 239/18723 | 2.79e-04 | 3.42e-03 | 73 |
GO:2000379 | Colorectum | AD | positive regulation of reactive oxygen species metabolic process | 29/3918 | 76/18723 | 4.31e-04 | 4.82e-03 | 29 |
GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
GO:0008361 | Colorectum | AD | regulation of cell size | 56/3918 | 181/18723 | 9.61e-04 | 9.07e-03 | 56 |
GO:0030641 | Colorectum | AD | regulation of cellular pH | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
GO:2000377 | Colorectum | AD | regulation of reactive oxygen species metabolic process | 48/3918 | 157/18723 | 2.77e-03 | 2.09e-02 | 48 |
GO:0051453 | Colorectum | AD | regulation of intracellular pH | 26/3918 | 75/18723 | 4.04e-03 | 2.82e-02 | 26 |
GO:0006885 | Colorectum | AD | regulation of pH | 30/3918 | 91/18723 | 4.95e-03 | 3.32e-02 | 30 |
GO:0055067 | Colorectum | AD | monovalent inorganic cation homeostasis | 45/3918 | 151/18723 | 6.19e-03 | 3.88e-02 | 45 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:00325352 | Colorectum | MSS | regulation of cellular component size | 127/3467 | 383/18723 | 3.44e-12 | 5.79e-10 | 127 |
GO:19026002 | Colorectum | MSS | proton transmembrane transport | 57/3467 | 157/18723 | 1.00e-07 | 4.81e-06 | 57 |
GO:00160502 | Colorectum | MSS | vesicle organization | 93/3467 | 300/18723 | 1.04e-07 | 4.97e-06 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLCN3 | insertion | Nonsense_Mutation | novel | c.1956_1957insTGAAAAAAGTAAGCA | p.Thr652_Leu653insTer | p.T652_L653ins* | P51790 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CLCN3 | insertion | Nonsense_Mutation | novel | c.578_579insAGACTCCTAAATAAA | p.Trp193delinsTer | p.W193delins* | P51790 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1182 | CLCN3 | DRUGGABLE GENOME, ION CHANNEL, CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, KINASE, TRANSPORTER | blocker | 178101102 | PHLORETIN | |
1182 | CLCN3 | DRUGGABLE GENOME, ION CHANNEL, CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, KINASE, TRANSPORTER | DESACETYLBUFOTALIN | DESACETYLBUFOTALIN | 23799775 | |
1182 | CLCN3 | DRUGGABLE GENOME, ION CHANNEL, CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, KINASE, TRANSPORTER | CINOBUFAGIN | CINOBUFAGIN | 23799775 | |
1182 | CLCN3 | DRUGGABLE GENOME, ION CHANNEL, CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, KINASE, TRANSPORTER | BUFALIN | BUFALIN | 23799775 |
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