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Gene: CHRD |
Gene summary for CHRD |
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Gene information | Species | Human | Gene symbol | CHRD | Gene ID | 8646 |
Gene name | chordin | |
Gene Alias | CHRD | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | E7ESX1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8646 | CHRD | HCC1_Meng | Human | Liver | HCC | 3.88e-26 | 6.41e-02 | 0.0246 |
8646 | CHRD | HCC2 | Human | Liver | HCC | 3.81e-11 | 2.32e+00 | 0.5341 |
8646 | CHRD | S014 | Human | Liver | HCC | 2.07e-17 | 9.07e-01 | 0.2254 |
8646 | CHRD | S015 | Human | Liver | HCC | 1.29e-26 | 1.36e+00 | 0.2375 |
8646 | CHRD | S016 | Human | Liver | HCC | 4.30e-34 | 1.19e+00 | 0.2243 |
8646 | CHRD | S028 | Human | Liver | HCC | 1.19e-05 | 3.60e-01 | 0.2503 |
8646 | CHRD | S029 | Human | Liver | HCC | 6.50e-03 | 3.52e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004578512 | Liver | HCC | positive regulation of cell adhesion | 215/7958 | 437/18723 | 2.53e-03 | 1.22e-02 | 215 |
GO:00219154 | Liver | HCC | neural tube development | 82/7958 | 152/18723 | 2.83e-03 | 1.33e-02 | 82 |
GO:000164911 | Liver | HCC | osteoblast differentiation | 115/7958 | 229/18723 | 1.08e-02 | 3.99e-02 | 115 |
GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
GO:000150315 | Oral cavity | LP | ossification | 123/4623 | 408/18723 | 6.55e-03 | 3.84e-02 | 123 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHRD | SNV | Missense_Mutation | novel | c.889N>C | p.Val297Leu | p.V297L | Q9H2X0 | protein_coding | tolerated(0.6) | benign(0.033) | TCGA-92-7340-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CHRD | SNV | Missense_Mutation | novel | c.221T>C | p.Val74Ala | p.V74A | Q9H2X0 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-96-7544-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CHRD | SNV | Missense_Mutation | c.868N>C | p.Glu290Gln | p.E290Q | Q9H2X0 | protein_coding | tolerated(0.09) | probably_damaging(0.971) | TCGA-98-A53I-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | navelbine | SD | |
CHRD | SNV | Missense_Mutation | novel | c.1220A>T | p.Gln407Leu | p.Q407L | Q9H2X0 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-L3-A4E7-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CHRD | deletion | Frame_Shift_Del | novel | c.1505delT | p.Phe502SerfsTer2 | p.F502Sfs*2 | Q9H2X0 | protein_coding | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CHRD | SNV | Missense_Mutation | novel | c.297N>G | p.Cys99Trp | p.C99W | Q9H2X0 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BA-4076-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
CHRD | SNV | Missense_Mutation | novel | c.1534N>T | p.Asp512Tyr | p.D512Y | Q9H2X0 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-BA-6871-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CHRD | SNV | Missense_Mutation | novel | c.907N>A | p.Leu303Ile | p.L303I | Q9H2X0 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CHRD | SNV | Missense_Mutation | novel | c.611N>T | p.Arg204Leu | p.R204L | Q9H2X0 | protein_coding | tolerated(0.06) | benign(0.017) | TCGA-CV-7104-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHRD | SNV | Missense_Mutation | rs769116532 | c.2033N>T | p.Ala678Val | p.A678V | Q9H2X0 | protein_coding | tolerated(0.45) | benign(0) | TCGA-CV-7104-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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