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Gene: CFAP69 |
Gene summary for CFAP69 |
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Gene information | Species | Human | Gene symbol | CFAP69 | Gene ID | 79846 |
Gene name | cilia and flagella associated protein 69 | |
Gene Alias | C7orf63 | |
Cytomap | 7q21.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A5D8W1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79846 | CFAP69 | PTC05 | Human | Thyroid | PTC | 2.31e-02 | 1.36e-01 | 0.2065 |
79846 | CFAP69 | PTC06 | Human | Thyroid | PTC | 3.49e-02 | 7.84e-02 | 0.2057 |
79846 | CFAP69 | PTC07 | Human | Thyroid | PTC | 1.11e-03 | 6.38e-02 | 0.2044 |
79846 | CFAP69 | ATC13 | Human | Thyroid | ATC | 2.57e-60 | 1.12e+00 | 0.34 |
79846 | CFAP69 | ATC5 | Human | Thyroid | ATC | 4.74e-72 | 1.19e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00328866 | Thyroid | PTC | regulation of microtubule-based process | 105/5968 | 240/18723 | 6.91e-05 | 6.03e-04 | 105 |
GO:003288613 | Thyroid | ATC | regulation of microtubule-based process | 114/6293 | 240/18723 | 5.17e-06 | 5.59e-05 | 114 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP69 | SNV | Missense_Mutation | rs772196992 | c.934N>G | p.Ile312Val | p.I312V | A5D8W1 | protein_coding | tolerated(0.08) | benign(0.107) | TCGA-O2-A52V-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CFAP69 | SNV | Missense_Mutation | c.1061N>C | p.Gly354Ala | p.G354A | A5D8W1 | protein_coding | tolerated(0.14) | benign(0.359) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CFAP69 | SNV | Missense_Mutation | novel | c.961N>A | p.Gln321Lys | p.Q321K | A5D8W1 | protein_coding | tolerated(0.11) | benign(0.269) | TCGA-CN-5359-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
CFAP69 | SNV | Missense_Mutation | rs762305642 | c.1873T>A | p.Phe625Ile | p.F625I | A5D8W1 | protein_coding | tolerated(0.34) | benign(0.194) | TCGA-CV-7414-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CFAP69 | SNV | Missense_Mutation | novel | c.2750N>T | p.Pro917Leu | p.P917L | A5D8W1 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CFAP69 | SNV | Missense_Mutation | novel | c.1182N>C | p.Leu394Phe | p.L394F | A5D8W1 | protein_coding | tolerated(0.07) | benign(0.246) | TCGA-CV-A6JU-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP69 | SNV | Missense_Mutation | novel | c.2509N>A | p.Glu837Lys | p.E837K | A5D8W1 | protein_coding | tolerated(0.11) | benign(0.009) | TCGA-D6-A6EQ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CFAP69 | SNV | Missense_Mutation | novel | c.1798N>T | p.Pro600Ser | p.P600S | A5D8W1 | protein_coding | tolerated(1) | benign(0) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CFAP69 | SNV | Missense_Mutation | novel | c.325G>A | p.Glu109Lys | p.E109K | A5D8W1 | protein_coding | tolerated(0.05) | benign(0.346) | TCGA-QK-A6VC-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP69 | SNV | Missense_Mutation | novel | c.169N>C | p.Glu57Gln | p.E57Q | A5D8W1 | protein_coding | deleterious(0.02) | benign(0.11) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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