![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CFAP43 |
Gene summary for CFAP43 |
![]() |
Gene information | Species | Human | Gene symbol | CFAP43 | Gene ID | 80217 |
Gene name | cilia and flagella associated protein 43 | |
Gene Alias | C10orf79 | |
Cytomap | 10q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8NDM7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80217 | CFAP43 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.00e-03 | 7.11e-01 | -0.0238 |
80217 | CFAP43 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 4.12e-03 | 6.71e-01 | -0.0186 |
80217 | CFAP43 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.24e-04 | 6.83e-01 | -0.0263 |
80217 | CFAP43 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.12e-03 | 1.78e-01 | -0.0132 |
80217 | CFAP43 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 3.91e-04 | 1.97e-01 | -0.013 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007585 | Lung | IAC | respiratory gaseous exchange by respiratory system | 18/2061 | 68/18723 | 2.99e-04 | 4.82e-03 | 18 |
GO:0099111 | Lung | IAC | microtubule-based transport | 35/2061 | 190/18723 | 1.55e-03 | 1.64e-02 | 35 |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
GO:00602711 | Lung | MIAC | cilium assembly | 37/967 | 337/18723 | 1.29e-05 | 9.85e-04 | 37 |
GO:00447821 | Lung | MIAC | cilium organization | 38/967 | 368/18723 | 3.93e-05 | 2.08e-03 | 38 |
GO:00075853 | Lung | MIAC | respiratory gaseous exchange by respiratory system | 11/967 | 68/18723 | 6.76e-04 | 1.59e-02 | 11 |
GO:00328861 | Lung | MIAC | regulation of microtubule-based process | 23/967 | 240/18723 | 3.27e-03 | 4.31e-02 | 23 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP43 | SNV | Missense_Mutation | novel | c.3862G>A | p.Asp1288Asn | p.D1288N | Q8NDM7 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP43 | SNV | Missense_Mutation | rs372598864 | c.3140G>A | p.Arg1047Gln | p.R1047Q | Q8NDM7 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP43 | SNV | Missense_Mutation | c.755C>A | p.Pro252His | p.P252H | Q8NDM7 | protein_coding | tolerated(0.06) | benign(0.057) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP43 | SNV | Missense_Mutation | novel | c.3287A>T | p.Lys1096Ile | p.K1096I | Q8NDM7 | protein_coding | deleterious(0) | benign(0.1) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP43 | SNV | Missense_Mutation | c.760C>T | p.Leu254Phe | p.L254F | Q8NDM7 | protein_coding | deleterious(0.01) | probably_damaging(0.967) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP43 | SNV | Missense_Mutation | novel | c.2647N>A | p.Glu883Lys | p.E883K | Q8NDM7 | protein_coding | tolerated(0.21) | benign(0.208) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFAP43 | SNV | Missense_Mutation | novel | c.661N>T | p.Asp221Tyr | p.D221Y | Q8NDM7 | protein_coding | tolerated(0.06) | possibly_damaging(0.693) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFAP43 | SNV | Missense_Mutation | novel | c.2747N>G | p.Glu916Gly | p.E916G | Q8NDM7 | protein_coding | deleterious(0) | possibly_damaging(0.818) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
CFAP43 | SNV | Missense_Mutation | novel | c.174N>T | p.Lys58Asn | p.K58N | Q8NDM7 | protein_coding | deleterious(0.01) | benign(0.295) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
CFAP43 | SNV | Missense_Mutation | rs760000742 | c.3305A>G | p.His1102Arg | p.H1102R | Q8NDM7 | protein_coding | tolerated(0.43) | benign(0) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |