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Gene: CD163 |
Gene summary for CD163 |
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Gene information | Species | Human | Gene symbol | CD163 | Gene ID | 9332 |
Gene name | CD163 molecule | |
Gene Alias | M130 | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0002526 | UniProtAcc | Q86VB7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9332 | CD163 | HCC1_Meng | Human | Liver | HCC | 8.69e-25 | 7.25e-02 | 0.0246 |
9332 | CD163 | HCC1 | Human | Liver | HCC | 3.33e-04 | 5.06e-01 | 0.5336 |
9332 | CD163 | Pt13.a | Human | Liver | HCC | 3.13e-05 | 2.34e-01 | 0.021 |
9332 | CD163 | Pt13.c | Human | Liver | HCC | 6.33e-12 | 6.58e-01 | 0.0076 |
9332 | CD163 | Pt14.d | Human | Liver | HCC | 3.53e-21 | 5.72e-01 | 0.0143 |
9332 | CD163 | S028 | Human | Liver | HCC | 8.28e-07 | 2.13e-01 | 0.2503 |
9332 | CD163 | S029 | Human | Liver | HCC | 4.49e-03 | 3.13e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00025262 | Liver | HCC | acute inflammatory response | 62/7958 | 112/18723 | 4.06e-03 | 1.77e-02 | 62 |
GO:00069532 | Liver | HCC | acute-phase response | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD163 | insertion | Frame_Shift_Ins | novel | c.2183_2184insGGGTAGAAAGGGCAACTCCACATTTAAGC | p.Cys728TrpfsTer15 | p.C728Wfs*15 | Q86VB7 | protein_coding | TCGA-B5-A11Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CD163 | insertion | Frame_Shift_Ins | novel | c.508_509insAGAAGGAAGAGGAAGAGGAAGCGGAGAAA | p.Gly170GlufsTer13 | p.G170Efs*13 | Q86VB7 | protein_coding | TCGA-B5-A11Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CD163 | insertion | Nonsense_Mutation | novel | c.2370_2371insTGAGTTGAGGACAAACATAGCTTAGAGAGAGAGGGGAAGGTGGATGAGATGAAATGCAATGGA | p.Gly790_Lys791insTer | p.G790_K791ins* | Q86VB7 | protein_coding | TCGA-BG-A0YV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
CD163 | insertion | Frame_Shift_Ins | novel | c.1802_1803insGTCATCACAGA | p.Gly602SerfsTer17 | p.G602Sfs*17 | Q86VB7 | protein_coding | TCGA-BG-A0YV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
CD163 | insertion | Nonsense_Mutation | novel | c.1278_1279insATCTAAAAAT | p.Tyr427IlefsTer2 | p.Y427Ifs*2 | Q86VB7 | protein_coding | TCGA-BS-A0UT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CD163 | insertion | In_Frame_Ins | novel | c.1802_1803insCCCAGCTGTCATCACAGA | p.Leu601_Gly602insProAlaValIleThrAsp | p.L601_G602insPAVITD | Q86VB7 | protein_coding | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CD163 | insertion | In_Frame_Ins | novel | c.508_509insAAGGAAGAGGAAGAGGAAGCGGAGAAA | p.Gly170delinsGluGlyArgGlyArgGlySerGlyGluArg | p.G170delinsEGRGRGSGER | Q86VB7 | protein_coding | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CD163 | SNV | Missense_Mutation | c.1937N>T | p.Trp646Leu | p.W646L | Q86VB7 | protein_coding | tolerated(0.12) | probably_damaging(1) | TCGA-G3-A5SJ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CD163 | SNV | Missense_Mutation | c.1008N>C | p.Gln336His | p.Q336H | Q86VB7 | protein_coding | tolerated(0.3) | benign(0.006) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CD163 | SNV | Missense_Mutation | novel | c.134G>T | p.Gly45Val | p.G45V | Q86VB7 | protein_coding | deleterious(0) | possibly_damaging(0.481) | TCGA-05-4398-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9332 | CD163 | DRUGGABLE GENOME, KINASE, EXTERNAL SIDE OF PLASMA MEMBRANE | GLUCOCORTICOID | 9712057 | ||
9332 | CD163 | DRUGGABLE GENOME, KINASE, EXTERNAL SIDE OF PLASMA MEMBRANE | FLUTICASONE PROPIONATE | 9712057 |
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