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Gene: CCDC88C |
Gene summary for CCDC88C |
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Gene information | Species | Human | Gene symbol | CCDC88C | Gene ID | 440193 |
Gene name | coiled-coil domain containing 88C | |
Gene Alias | DAPLE | |
Cytomap | 14q32.11-q32.12 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B4DZB8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
440193 | CCDC88C | LZE4T | Human | Esophagus | ESCC | 2.54e-04 | 1.57e-01 | 0.0811 |
440193 | CCDC88C | LZE20T | Human | Esophagus | ESCC | 7.00e-05 | 2.56e-01 | 0.0662 |
440193 | CCDC88C | LZE22T | Human | Esophagus | ESCC | 1.87e-04 | 3.43e-01 | 0.068 |
440193 | CCDC88C | LZE24T | Human | Esophagus | ESCC | 9.42e-15 | 5.58e-01 | 0.0596 |
440193 | CCDC88C | P1T-E | Human | Esophagus | ESCC | 3.08e-04 | 2.14e-01 | 0.0875 |
440193 | CCDC88C | P2T-E | Human | Esophagus | ESCC | 1.67e-13 | 2.05e-01 | 0.1177 |
440193 | CCDC88C | P4T-E | Human | Esophagus | ESCC | 5.58e-12 | 4.41e-01 | 0.1323 |
440193 | CCDC88C | P5T-E | Human | Esophagus | ESCC | 1.33e-15 | 2.33e-01 | 0.1327 |
440193 | CCDC88C | P8T-E | Human | Esophagus | ESCC | 2.28e-10 | 1.80e-01 | 0.0889 |
440193 | CCDC88C | P9T-E | Human | Esophagus | ESCC | 7.72e-05 | 6.92e-02 | 0.1131 |
440193 | CCDC88C | P10T-E | Human | Esophagus | ESCC | 3.28e-11 | 1.96e-01 | 0.116 |
440193 | CCDC88C | P12T-E | Human | Esophagus | ESCC | 2.77e-34 | 6.36e-01 | 0.1122 |
440193 | CCDC88C | P15T-E | Human | Esophagus | ESCC | 1.95e-24 | 6.56e-01 | 0.1149 |
440193 | CCDC88C | P16T-E | Human | Esophagus | ESCC | 2.23e-07 | 1.25e-01 | 0.1153 |
440193 | CCDC88C | P20T-E | Human | Esophagus | ESCC | 1.88e-12 | 2.22e-01 | 0.1124 |
440193 | CCDC88C | P21T-E | Human | Esophagus | ESCC | 3.36e-09 | 1.99e-01 | 0.1617 |
440193 | CCDC88C | P22T-E | Human | Esophagus | ESCC | 1.61e-07 | 1.36e-01 | 0.1236 |
440193 | CCDC88C | P23T-E | Human | Esophagus | ESCC | 2.79e-10 | 3.42e-01 | 0.108 |
440193 | CCDC88C | P24T-E | Human | Esophagus | ESCC | 1.51e-02 | 1.04e-01 | 0.1287 |
440193 | CCDC88C | P26T-E | Human | Esophagus | ESCC | 1.24e-08 | 2.35e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:003109818 | Esophagus | ESCC | stress-activated protein kinase signaling cascade | 154/8552 | 247/18723 | 8.53e-08 | 1.44e-06 | 154 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
GO:006082817 | Esophagus | ESCC | regulation of canonical Wnt signaling pathway | 153/8552 | 253/18723 | 1.38e-06 | 1.67e-05 | 153 |
GO:00316486 | Esophagus | ESCC | protein destabilization | 33/8552 | 46/18723 | 3.06e-04 | 1.83e-03 | 33 |
GO:00311227 | Esophagus | ESCC | cytoplasmic microtubule organization | 38/8552 | 56/18723 | 6.60e-04 | 3.50e-03 | 38 |
GO:00301788 | Esophagus | ESCC | negative regulation of Wnt signaling pathway | 97/8552 | 170/18723 | 1.81e-03 | 8.31e-03 | 97 |
GO:00355671 | Esophagus | ESCC | non-canonical Wnt signaling pathway | 45/8552 | 72/18723 | 2.97e-03 | 1.24e-02 | 45 |
GO:00900905 | Esophagus | ESCC | negative regulation of canonical Wnt signaling pathway | 78/8552 | 137/18723 | 5.17e-03 | 1.95e-02 | 78 |
GO:00033824 | Esophagus | ESCC | epithelial cell morphogenesis | 22/8552 | 33/18723 | 1.22e-02 | 4.08e-02 | 22 |
GO:003164720 | Oral cavity | OSCC | regulation of protein stability | 193/7305 | 298/18723 | 1.30e-19 | 1.95e-17 | 193 |
GO:003109816 | Oral cavity | OSCC | stress-activated protein kinase signaling cascade | 141/7305 | 247/18723 | 5.74e-09 | 1.25e-07 | 141 |
GO:003070510 | Oral cavity | OSCC | cytoskeleton-dependent intracellular transport | 113/7305 | 195/18723 | 6.03e-08 | 1.09e-06 | 113 |
GO:001605510 | Oral cavity | OSCC | Wnt signaling pathway | 227/7305 | 444/18723 | 1.10e-07 | 1.87e-06 | 227 |
GO:019873810 | Oral cavity | OSCC | cell-cell signaling by wnt | 227/7305 | 446/18723 | 1.75e-07 | 2.86e-06 | 227 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0431014 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0431015 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0431023 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
hsa0431033 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC88C | SNV | Missense_Mutation | rs372621845 | c.2608N>T | p.Arg870Cys | p.R870C | Q9P219 | protein_coding | deleterious(0) | possibly_damaging(0.836) | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC88C | SNV | Missense_Mutation | rs778090862 | c.1469A>T | p.Glu490Val | p.E490V | Q9P219 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-CC-A5UD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
CCDC88C | SNV | Missense_Mutation | c.2404G>C | p.Asp802His | p.D802H | Q9P219 | protein_coding | deleterious(0.02) | possibly_damaging(0.535) | TCGA-MI-A75C-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CCDC88C | SNV | Missense_Mutation | novel | c.2335A>C | p.Ser779Arg | p.S779R | Q9P219 | protein_coding | tolerated(0.09) | benign(0.017) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |
CCDC88C | SNV | Missense_Mutation | novel | c.3278N>C | p.Gln1093Pro | p.Q1093P | Q9P219 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
CCDC88C | SNV | Missense_Mutation | c.215A>T | p.Asn72Ile | p.N72I | Q9P219 | protein_coding | tolerated(0.06) | possibly_damaging(0.595) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CCDC88C | SNV | Missense_Mutation | c.3437N>G | p.Lys1146Arg | p.K1146R | Q9P219 | protein_coding | tolerated(0.66) | benign(0.015) | TCGA-75-7027-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
CCDC88C | SNV | Missense_Mutation | novel | c.341G>T | p.Gly114Val | p.G114V | Q9P219 | protein_coding | tolerated(0.06) | possibly_damaging(0.855) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
CCDC88C | SNV | Missense_Mutation | c.3342N>T | p.Gln1114His | p.Q1114H | Q9P219 | protein_coding | deleterious(0) | benign(0.418) | TCGA-78-7633-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CCDC88C | SNV | Missense_Mutation | c.2114A>G | p.Glu705Gly | p.E705G | Q9P219 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-91-A4BC-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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