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Gene: CCDC18 |
Gene summary for CCDC18 |
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Gene information | Species | Human | Gene symbol | CCDC18 | Gene ID | 343099 |
Gene name | coiled-coil domain containing 18 | |
Gene Alias | NY-SAR-41 | |
Cytomap | 1p22.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q5T9S5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
343099 | CCDC18 | P2T-E | Human | Esophagus | ESCC | 2.76e-12 | 2.94e-01 | 0.1177 |
343099 | CCDC18 | P4T-E | Human | Esophagus | ESCC | 6.07e-05 | 1.48e-01 | 0.1323 |
343099 | CCDC18 | P5T-E | Human | Esophagus | ESCC | 1.10e-10 | 2.61e-01 | 0.1327 |
343099 | CCDC18 | P8T-E | Human | Esophagus | ESCC | 3.79e-03 | 1.04e-01 | 0.0889 |
343099 | CCDC18 | P9T-E | Human | Esophagus | ESCC | 2.34e-05 | 1.27e-01 | 0.1131 |
343099 | CCDC18 | P10T-E | Human | Esophagus | ESCC | 7.09e-09 | 2.93e-01 | 0.116 |
343099 | CCDC18 | P12T-E | Human | Esophagus | ESCC | 2.23e-46 | 9.05e-01 | 0.1122 |
343099 | CCDC18 | P16T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.39e-01 | 0.1153 |
343099 | CCDC18 | P20T-E | Human | Esophagus | ESCC | 2.57e-04 | 2.17e-01 | 0.1124 |
343099 | CCDC18 | P21T-E | Human | Esophagus | ESCC | 1.91e-03 | 1.58e-01 | 0.1617 |
343099 | CCDC18 | P22T-E | Human | Esophagus | ESCC | 1.50e-06 | 1.04e-01 | 0.1236 |
343099 | CCDC18 | P23T-E | Human | Esophagus | ESCC | 7.20e-03 | 2.06e-01 | 0.108 |
343099 | CCDC18 | P26T-E | Human | Esophagus | ESCC | 3.25e-04 | 1.31e-01 | 0.1276 |
343099 | CCDC18 | P27T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.58e-01 | 0.1055 |
343099 | CCDC18 | P28T-E | Human | Esophagus | ESCC | 2.18e-16 | 3.73e-01 | 0.1149 |
343099 | CCDC18 | P30T-E | Human | Esophagus | ESCC | 3.78e-03 | 2.66e-01 | 0.137 |
343099 | CCDC18 | P31T-E | Human | Esophagus | ESCC | 2.92e-10 | 2.57e-01 | 0.1251 |
343099 | CCDC18 | P32T-E | Human | Esophagus | ESCC | 1.07e-09 | 2.46e-01 | 0.1666 |
343099 | CCDC18 | P47T-E | Human | Esophagus | ESCC | 3.18e-02 | 9.38e-02 | 0.1067 |
343099 | CCDC18 | P48T-E | Human | Esophagus | ESCC | 8.79e-04 | 1.39e-01 | 0.0959 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
GO:00995185 | Esophagus | ESCC | vesicle cytoskeletal trafficking | 50/8552 | 73/18723 | 6.75e-05 | 5.12e-04 | 50 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:007169210 | Esophagus | ESCC | protein localization to extracellular region | 193/8552 | 368/18723 | 5.01e-03 | 1.92e-02 | 193 |
GO:0009743111 | Esophagus | ESCC | response to carbohydrate | 135/8552 | 253/18723 | 8.16e-03 | 2.89e-02 | 135 |
GO:00097437 | Liver | NAFLD | response to carbohydrate | 45/1882 | 253/18723 | 1.07e-04 | 2.11e-03 | 45 |
GO:00425936 | Liver | NAFLD | glucose homeostasis | 45/1882 | 258/18723 | 1.71e-04 | 3.08e-03 | 45 |
GO:00335006 | Liver | NAFLD | carbohydrate homeostasis | 45/1882 | 259/18723 | 1.87e-04 | 3.29e-03 | 45 |
GO:00342847 | Liver | NAFLD | response to monosaccharide | 37/1882 | 225/18723 | 1.86e-03 | 1.91e-02 | 37 |
GO:00307055 | Liver | NAFLD | cytoskeleton-dependent intracellular transport | 33/1882 | 195/18723 | 1.98e-03 | 1.98e-02 | 33 |
GO:00097467 | Liver | NAFLD | response to hexose | 36/1882 | 219/18723 | 2.14e-03 | 2.08e-02 | 36 |
GO:00516565 | Liver | NAFLD | establishment of organelle localization | 57/1882 | 390/18723 | 2.52e-03 | 2.34e-02 | 57 |
GO:00516485 | Liver | NAFLD | vesicle localization | 30/1882 | 177/18723 | 3.01e-03 | 2.72e-02 | 30 |
GO:00355926 | Liver | NAFLD | establishment of protein localization to extracellular region | 52/1882 | 360/18723 | 4.80e-03 | 3.81e-02 | 52 |
GO:00516505 | Liver | NAFLD | establishment of vesicle localization | 27/1882 | 161/18723 | 5.47e-03 | 4.20e-02 | 27 |
GO:00016786 | Liver | NAFLD | cellular glucose homeostasis | 28/1882 | 172/18723 | 7.15e-03 | 4.96e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC18 | SNV | Missense_Mutation | c.3487G>A | p.Glu1163Lys | p.E1163K | Q5T9S5 | protein_coding | tolerated(0.11) | possibly_damaging(0.888) | TCGA-50-5044-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CCDC18 | SNV | Missense_Mutation | c.2893N>A | p.Gln965Lys | p.Q965K | Q5T9S5 | protein_coding | deleterious(0.01) | probably_damaging(0.915) | TCGA-55-6979-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
CCDC18 | SNV | Missense_Mutation | c.2018N>T | p.Ser673Phe | p.S673F | Q5T9S5 | protein_coding | tolerated(0.08) | possibly_damaging(0.9) | TCGA-55-7727-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CCDC18 | SNV | Missense_Mutation | novel | c.3078G>T | p.Gln1026His | p.Q1026H | Q5T9S5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CCDC18 | SNV | Missense_Mutation | c.3584N>T | p.Ser1195Phe | p.S1195F | Q5T9S5 | protein_coding | deleterious(0.01) | probably_damaging(0.952) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CCDC18 | SNV | Missense_Mutation | novel | c.2996N>C | p.Ile999Thr | p.I999T | Q5T9S5 | protein_coding | deleterious(0) | benign(0.116) | TCGA-56-8304-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC18 | SNV | Missense_Mutation | c.3878N>A | p.Thr1293Asn | p.T1293N | Q5T9S5 | protein_coding | deleterious(0) | benign(0.027) | TCGA-66-2742-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CCDC18 | SNV | Missense_Mutation | c.3157N>A | p.Glu1053Lys | p.E1053K | Q5T9S5 | protein_coding | deleterious(0.02) | possibly_damaging(0.475) | TCGA-66-2759-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
CCDC18 | insertion | Frame_Shift_Ins | novel | c.3288_3289insGCTTTAAACACTCATAT | p.Leu1097AlafsTer7 | p.L1097Afs*7 | Q5T9S5 | protein_coding | TCGA-91-A4BD-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CCDC18 | SNV | Missense_Mutation | novel | c.17N>T | p.Ser6Leu | p.S6L | Q5T9S5 | protein_coding | tolerated_low_confidence(0.14) | benign(0.003) | TCGA-BA-A6DJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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