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Gene: ARHGEF26 |
Gene summary for ARHGEF26 |
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Gene information | Species | Human | Gene symbol | ARHGEF26 | Gene ID | 26084 |
Gene name | Rho guanine nucleotide exchange factor 26 | |
Gene Alias | CSGEF | |
Cytomap | 3q25.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A140VJU4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26084 | ARHGEF26 | LZE2T | Human | Esophagus | ESCC | 6.37e-03 | 4.73e-01 | 0.082 |
26084 | ARHGEF26 | LZE4T | Human | Esophagus | ESCC | 7.60e-05 | 2.76e-01 | 0.0811 |
26084 | ARHGEF26 | LZE7T | Human | Esophagus | ESCC | 4.42e-10 | 6.57e-01 | 0.0667 |
26084 | ARHGEF26 | LZE21D1 | Human | Esophagus | HGIN | 6.38e-05 | 7.84e-01 | 0.0632 |
26084 | ARHGEF26 | LZE24T | Human | Esophagus | ESCC | 4.27e-09 | 4.71e-01 | 0.0596 |
26084 | ARHGEF26 | LZE21T | Human | Esophagus | ESCC | 6.21e-11 | 7.18e-01 | 0.0655 |
26084 | ARHGEF26 | P1T-E | Human | Esophagus | ESCC | 3.36e-02 | 1.24e-01 | 0.0875 |
26084 | ARHGEF26 | P2T-E | Human | Esophagus | ESCC | 7.36e-20 | 4.35e-01 | 0.1177 |
26084 | ARHGEF26 | P4T-E | Human | Esophagus | ESCC | 1.15e-12 | 4.72e-01 | 0.1323 |
26084 | ARHGEF26 | P9T-E | Human | Esophagus | ESCC | 2.01e-10 | 3.09e-01 | 0.1131 |
26084 | ARHGEF26 | P10T-E | Human | Esophagus | ESCC | 4.12e-36 | 6.11e-01 | 0.116 |
26084 | ARHGEF26 | P11T-E | Human | Esophagus | ESCC | 1.18e-02 | 2.24e-01 | 0.1426 |
26084 | ARHGEF26 | P12T-E | Human | Esophagus | ESCC | 5.04e-31 | 6.20e-01 | 0.1122 |
26084 | ARHGEF26 | P15T-E | Human | Esophagus | ESCC | 4.44e-18 | 4.80e-01 | 0.1149 |
26084 | ARHGEF26 | P16T-E | Human | Esophagus | ESCC | 9.04e-20 | 3.16e-01 | 0.1153 |
26084 | ARHGEF26 | P19T-E | Human | Esophagus | ESCC | 7.39e-04 | 2.41e-01 | 0.1662 |
26084 | ARHGEF26 | P20T-E | Human | Esophagus | ESCC | 1.31e-05 | 2.72e-01 | 0.1124 |
26084 | ARHGEF26 | P23T-E | Human | Esophagus | ESCC | 3.13e-06 | 1.29e-01 | 0.108 |
26084 | ARHGEF26 | P26T-E | Human | Esophagus | ESCC | 1.83e-22 | 4.79e-01 | 0.1276 |
26084 | ARHGEF26 | P27T-E | Human | Esophagus | ESCC | 3.41e-26 | 5.47e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
GO:000188510 | Esophagus | ESCC | endothelial cell development | 44/8552 | 64/18723 | 1.59e-04 | 1.05e-03 | 44 |
GO:00315299 | Esophagus | ESCC | ruffle organization | 39/8552 | 56/18723 | 2.44e-04 | 1.51e-03 | 39 |
GO:00971789 | Esophagus | ESCC | ruffle assembly | 32/8552 | 44/18723 | 2.50e-04 | 1.54e-03 | 32 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:004544610 | Esophagus | ESCC | endothelial cell differentiation | 67/8552 | 118/18723 | 9.86e-03 | 3.40e-02 | 67 |
GO:000315818 | Esophagus | ESCC | endothelium development | 76/8552 | 136/18723 | 1.05e-02 | 3.59e-02 | 76 |
GO:00033824 | Esophagus | ESCC | epithelial cell morphogenesis | 22/8552 | 33/18723 | 1.22e-02 | 4.08e-02 | 22 |
GO:000206413 | Lung | AIS | epithelial cell development | 48/1849 | 220/18723 | 1.06e-07 | 1.18e-05 | 48 |
GO:004308711 | Lung | AIS | regulation of GTPase activity | 65/1849 | 348/18723 | 3.35e-07 | 2.83e-05 | 65 |
GO:004354711 | Lung | AIS | positive regulation of GTPase activity | 44/1849 | 255/18723 | 1.74e-04 | 3.64e-03 | 44 |
GO:000188513 | Lung | AIS | endothelial cell development | 16/1849 | 64/18723 | 3.78e-04 | 6.61e-03 | 16 |
GO:003152912 | Lung | AIS | ruffle organization | 14/1849 | 56/18723 | 8.61e-04 | 1.17e-02 | 14 |
GO:000315812 | Lung | AIS | endothelium development | 25/1849 | 136/18723 | 1.67e-03 | 1.90e-02 | 25 |
GO:009717811 | Lung | AIS | ruffle assembly | 11/1849 | 44/18723 | 3.01e-03 | 2.97e-02 | 11 |
GO:009063011 | Lung | AIS | activation of GTPase activity | 21/1849 | 115/18723 | 4.07e-03 | 3.65e-02 | 21 |
GO:004544612 | Lung | AIS | endothelial cell differentiation | 21/1849 | 118/18723 | 5.54e-03 | 4.71e-02 | 21 |
GO:000206417 | Prostate | BPH | epithelial cell development | 85/3107 | 220/18723 | 3.16e-15 | 4.55e-13 | 85 |
GO:000315814 | Prostate | BPH | endothelium development | 49/3107 | 136/18723 | 3.17e-08 | 9.07e-07 | 49 |
GO:00454468 | Prostate | BPH | endothelial cell differentiation | 43/3107 | 118/18723 | 1.49e-07 | 3.46e-06 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0510039 | Esophagus | HGIN | Bacterial invasion of epithelial cells | 30/1383 | 77/8465 | 1.49e-06 | 2.31e-05 | 1.84e-05 | 30 |
hsa0513239 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa05100114 | Esophagus | HGIN | Bacterial invasion of epithelial cells | 30/1383 | 77/8465 | 1.49e-06 | 2.31e-05 | 1.84e-05 | 30 |
hsa05132115 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05100211 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05100310 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa0510023 | Lung | AIS | Bacterial invasion of epithelial cells | 25/961 | 77/8465 | 6.03e-07 | 2.44e-05 | 1.56e-05 | 25 |
hsa0513223 | Lung | AIS | Salmonella infection | 50/961 | 249/8465 | 3.47e-05 | 5.62e-04 | 3.59e-04 | 50 |
hsa0510033 | Lung | AIS | Bacterial invasion of epithelial cells | 25/961 | 77/8465 | 6.03e-07 | 2.44e-05 | 1.56e-05 | 25 |
hsa0513233 | Lung | AIS | Salmonella infection | 50/961 | 249/8465 | 3.47e-05 | 5.62e-04 | 3.59e-04 | 50 |
hsa0513228 | Prostate | BPH | Salmonella infection | 99/1718 | 249/8465 | 7.26e-13 | 1.50e-11 | 9.27e-12 | 99 |
hsa05132113 | Prostate | BPH | Salmonella infection | 99/1718 | 249/8465 | 7.26e-13 | 1.50e-11 | 9.27e-12 | 99 |
hsa0513229 | Prostate | Tumor | Salmonella infection | 98/1791 | 249/8465 | 2.55e-11 | 5.28e-10 | 3.27e-10 | 98 |
hsa0510029 | Prostate | Tumor | Bacterial invasion of epithelial cells | 36/1791 | 77/8465 | 4.38e-07 | 4.53e-06 | 2.81e-06 | 36 |
hsa0513237 | Prostate | Tumor | Salmonella infection | 98/1791 | 249/8465 | 2.55e-11 | 5.28e-10 | 3.27e-10 | 98 |
hsa0510037 | Prostate | Tumor | Bacterial invasion of epithelial cells | 36/1791 | 77/8465 | 4.38e-07 | 4.53e-06 | 2.81e-06 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF26 | SNV | Missense_Mutation | c.1114N>C | p.Asp372His | p.D372H | Q96DR7 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-ED-A7PZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ARHGEF26 | SNV | Missense_Mutation | novel | c.587N>T | p.Lys196Met | p.K196M | Q96DR7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.076) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
ARHGEF26 | SNV | Missense_Mutation | rs754708272 | c.1622G>A | p.Arg541Gln | p.R541Q | Q96DR7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-91-6847-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ARHGEF26 | SNV | Missense_Mutation | c.215N>T | p.Ser72Leu | p.S72L | Q96DR7 | protein_coding | tolerated_low_confidence(0.09) | benign(0) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARHGEF26 | SNV | Missense_Mutation | novel | c.1817N>T | p.Cys606Phe | p.C606F | Q96DR7 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-21-5783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF26 | SNV | Missense_Mutation | novel | c.1685C>T | p.Ser562Phe | p.S562F | Q96DR7 | protein_coding | deleterious(0.01) | possibly_damaging(0.694) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF26 | SNV | Missense_Mutation | novel | c.2089N>T | p.Ser697Cys | p.S697C | Q96DR7 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-33-AASD-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ARHGEF26 | SNV | Missense_Mutation | c.1553N>C | p.Val518Ala | p.V518A | Q96DR7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ARHGEF26 | SNV | Missense_Mutation | rs377732491 | c.2062G>A | p.Asp688Asn | p.D688N | Q96DR7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF26 | SNV | Missense_Mutation | c.1711N>G | p.Met571Val | p.M571V | Q96DR7 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-43-3920-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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