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Gene: ARHGAP24 |
Gene summary for ARHGAP24 |
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Gene information | Species | Human | Gene symbol | ARHGAP24 | Gene ID | 83478 |
Gene name | Rho GTPase activating protein 24 | |
Gene Alias | FILGAP | |
Cytomap | 4q21.23-q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q8N264 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83478 | ARHGAP24 | CA_HPV_3 | Human | Cervix | CC | 1.01e-07 | 2.42e-01 | 0.0414 |
83478 | ARHGAP24 | CCI_1 | Human | Cervix | CC | 6.50e-23 | 1.41e+00 | 0.528 |
83478 | ARHGAP24 | CCI_3 | Human | Cervix | CC | 1.02e-12 | 6.60e-01 | 0.516 |
83478 | ARHGAP24 | LZE7T | Human | Esophagus | ESCC | 8.33e-05 | 2.57e-01 | 0.0667 |
83478 | ARHGAP24 | LZE8T | Human | Esophagus | ESCC | 2.23e-08 | 3.30e-01 | 0.067 |
83478 | ARHGAP24 | P1T-E | Human | Esophagus | ESCC | 2.74e-03 | 1.58e-01 | 0.0875 |
83478 | ARHGAP24 | P2T-E | Human | Esophagus | ESCC | 1.07e-31 | 5.87e-01 | 0.1177 |
83478 | ARHGAP24 | P4T-E | Human | Esophagus | ESCC | 1.01e-13 | 3.66e-01 | 0.1323 |
83478 | ARHGAP24 | P8T-E | Human | Esophagus | ESCC | 2.29e-04 | 1.15e-01 | 0.0889 |
83478 | ARHGAP24 | P9T-E | Human | Esophagus | ESCC | 1.02e-10 | 3.06e-01 | 0.1131 |
83478 | ARHGAP24 | P10T-E | Human | Esophagus | ESCC | 3.65e-13 | 2.22e-01 | 0.116 |
83478 | ARHGAP24 | P11T-E | Human | Esophagus | ESCC | 1.79e-04 | 2.95e-01 | 0.1426 |
83478 | ARHGAP24 | P12T-E | Human | Esophagus | ESCC | 1.55e-29 | 5.66e-01 | 0.1122 |
83478 | ARHGAP24 | P15T-E | Human | Esophagus | ESCC | 1.22e-15 | 3.84e-01 | 0.1149 |
83478 | ARHGAP24 | P16T-E | Human | Esophagus | ESCC | 1.92e-06 | 1.12e-01 | 0.1153 |
83478 | ARHGAP24 | P19T-E | Human | Esophagus | ESCC | 2.84e-04 | 6.22e-01 | 0.1662 |
83478 | ARHGAP24 | P20T-E | Human | Esophagus | ESCC | 4.61e-13 | 3.04e-01 | 0.1124 |
83478 | ARHGAP24 | P22T-E | Human | Esophagus | ESCC | 8.81e-06 | 1.63e-01 | 0.1236 |
83478 | ARHGAP24 | P23T-E | Human | Esophagus | ESCC | 8.83e-18 | 4.35e-01 | 0.108 |
83478 | ARHGAP24 | P26T-E | Human | Esophagus | ESCC | 6.01e-41 | 8.11e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00443193 | Cervix | CC | wound healing, spreading of cells | 17/2311 | 34/18723 | 9.86e-08 | 5.25e-06 | 17 |
GO:00905053 | Cervix | CC | epiboly involved in wound healing | 17/2311 | 34/18723 | 9.86e-08 | 5.25e-06 | 17 |
GO:00905043 | Cervix | CC | epiboly | 17/2311 | 35/18723 | 1.70e-07 | 7.93e-06 | 17 |
GO:00020111 | Cervix | CC | morphogenesis of an epithelial sheet | 21/2311 | 57/18723 | 1.91e-06 | 5.97e-05 | 21 |
GO:00465785 | Cervix | CC | regulation of Ras protein signal transduction | 44/2311 | 189/18723 | 2.05e-05 | 3.73e-04 | 44 |
GO:00435476 | Cervix | CC | positive regulation of GTPase activity | 53/2311 | 255/18723 | 8.72e-05 | 1.16e-03 | 53 |
GO:00313456 | Cervix | CC | negative regulation of cell projection organization | 39/2311 | 186/18723 | 5.86e-04 | 5.57e-03 | 39 |
GO:0035313 | Cervix | CC | wound healing, spreading of epidermal cells | 8/2311 | 19/18723 | 1.14e-03 | 9.34e-03 | 8 |
GO:01200328 | Cervix | CC | regulation of plasma membrane bounded cell projection assembly | 38/2311 | 186/18723 | 1.14e-03 | 9.35e-03 | 38 |
GO:00604917 | Cervix | CC | regulation of cell projection assembly | 38/2311 | 188/18723 | 1.40e-03 | 1.10e-02 | 38 |
GO:00510585 | Cervix | CC | negative regulation of small GTPase mediated signal transduction | 15/2311 | 56/18723 | 2.60e-03 | 1.80e-02 | 15 |
GO:00166015 | Cervix | CC | Rac protein signal transduction | 12/2311 | 42/18723 | 3.82e-03 | 2.41e-02 | 12 |
GO:00465804 | Cervix | CC | negative regulation of Ras protein signal transduction | 13/2311 | 49/18723 | 5.34e-03 | 3.10e-02 | 13 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:00166019 | Esophagus | ESCC | Rac protein signal transduction | 33/8552 | 42/18723 | 1.35e-05 | 1.23e-04 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP24 | SNV | Missense_Mutation | c.585G>T | p.Lys195Asn | p.K195N | Q8N264 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BR-8690-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
ARHGAP24 | SNV | Missense_Mutation | c.1834N>C | p.Asp612His | p.D612H | Q8N264 | protein_coding | deleterious(0.01) | possibly_damaging(0.533) | TCGA-BR-A4J1-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ARHGAP24 | SNV | Missense_Mutation | novel | c.821T>C | p.Val274Ala | p.V274A | Q8N264 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
ARHGAP24 | SNV | Missense_Mutation | rs750379979 | c.1753G>T | p.Gly585Trp | p.G585W | Q8N264 | protein_coding | tolerated(0.06) | possibly_damaging(0.621) | TCGA-VQ-A94T-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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