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Gene: ADAM28 |
Gene summary for ADAM28 |
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Gene information | Species | Human | Gene symbol | ADAM28 | Gene ID | 10863 |
Gene name | ADAM metallopeptidase domain 28 | |
Gene Alias | ADAM 28 | |
Cytomap | 8p21.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UKQ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10863 | ADAM28 | LZE8T | Human | Esophagus | ESCC | 1.12e-03 | 9.10e-02 | 0.067 |
10863 | ADAM28 | P2T-E | Human | Esophagus | ESCC | 3.49e-03 | -1.37e-02 | 0.1177 |
10863 | ADAM28 | P8T-E | Human | Esophagus | ESCC | 1.79e-15 | 3.00e-01 | 0.0889 |
10863 | ADAM28 | P36T-E | Human | Esophagus | ESCC | 3.39e-03 | 1.32e-01 | 0.1187 |
10863 | ADAM28 | P37T-E | Human | Esophagus | ESCC | 3.40e-06 | 1.52e-01 | 0.1371 |
10863 | ADAM28 | P42T-E | Human | Esophagus | ESCC | 1.90e-02 | 1.50e-01 | 0.1175 |
10863 | ADAM28 | P47T-E | Human | Esophagus | ESCC | 4.30e-04 | -2.35e-02 | 0.1067 |
10863 | ADAM28 | P57T-E | Human | Esophagus | ESCC | 1.49e-09 | 2.22e-01 | 0.0926 |
10863 | ADAM28 | P61T-E | Human | Esophagus | ESCC | 1.11e-03 | 9.10e-02 | 0.099 |
10863 | ADAM28 | P62T-E | Human | Esophagus | ESCC | 3.23e-09 | 3.14e-01 | 0.1302 |
10863 | ADAM28 | P65T-E | Human | Esophagus | ESCC | 9.21e-04 | 7.91e-02 | 0.0978 |
10863 | ADAM28 | P74T-E | Human | Esophagus | ESCC | 4.22e-02 | 1.43e-01 | 0.1479 |
10863 | ADAM28 | P82T-E | Human | Esophagus | ESCC | 2.26e-07 | 5.60e-01 | 0.1072 |
10863 | ADAM28 | P94T-E | Human | Esophagus | ESCC | 1.28e-03 | 1.02e+00 | 0.0879 |
10863 | ADAM28 | P104T-E | Human | Esophagus | ESCC | 1.98e-14 | 8.56e-01 | 0.0931 |
10863 | ADAM28 | P128T-E | Human | Esophagus | ESCC | 2.19e-07 | 2.76e-01 | 0.1241 |
10863 | ADAM28 | Pat01-B | Human | Stomach | GC | 1.42e-18 | -7.23e-01 | 0.5754 |
10863 | ADAM28 | Pat02-B | Human | Stomach | GC | 2.21e-32 | -6.00e-01 | 0.0368 |
10863 | ADAM28 | Pat03-B | Human | Stomach | GC | 4.78e-19 | -6.88e-01 | 0.3693 |
10863 | ADAM28 | Pat04-B | Human | Stomach | GC | 1.40e-19 | -2.87e-01 | -0.1483 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAM28 | insertion | Frame_Shift_Ins | rs570442888 | c.224dupA | p.Asn75LysfsTer15 | p.N75Kfs*15 | Q9UKQ2 | protein_coding | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADAM28 | insertion | Frame_Shift_Ins | rs570442888 | c.216_217insA | p.Asn75LysfsTer15 | p.N75Kfs*15 | Q9UKQ2 | protein_coding | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | ||
ADAM28 | insertion | Frame_Shift_Ins | rs570442888 | c.216_217insA | p.Asn75LysfsTer15 | p.N75Kfs*15 | Q9UKQ2 | protein_coding | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADAM28 | insertion | Frame_Shift_Ins | rs570442888 | c.224dupA | p.Asn75LysfsTer15 | p.N75Kfs*15 | Q9UKQ2 | protein_coding | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
ADAM28 | insertion | Frame_Shift_Ins | rs570442888 | c.224dupA | p.Asn75LysfsTer15 | p.N75Kfs*15 | Q9UKQ2 | protein_coding | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
ADAM28 | insertion | Frame_Shift_Ins | novel | c.1223_1224insA | p.Ile409AsnfsTer14 | p.I409Nfs*14 | Q9UKQ2 | protein_coding | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ADAM28 | insertion | Frame_Shift_Ins | rs570442888 | c.216_217insA | p.Asn75LysfsTer15 | p.N75Kfs*15 | Q9UKQ2 | protein_coding | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |||
ADAM28 | SNV | Missense_Mutation | c.1990N>A | p.His664Asn | p.H664N | Q9UKQ2 | protein_coding | tolerated(0.69) | benign(0) | TCGA-EM-A2CK-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ADAM28 | SNV | Missense_Mutation | novel | c.296N>A | p.Pro99Gln | p.P99Q | Q9UKQ2 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-H2-A2K9-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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