![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: AASDH |
Gene summary for AASDH |
![]() |
Gene information | Species | Human | Gene symbol | AASDH | Gene ID | 132949 |
Gene name | aminoadipate-semialdehyde dehydrogenase | |
Gene Alias | ACSF4 | |
Cytomap | 4q12 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | B4E2K0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
132949 | AASDH | LZE4T | Human | Esophagus | ESCC | 1.95e-02 | 1.82e-01 | 0.0811 |
132949 | AASDH | P1T-E | Human | Esophagus | ESCC | 2.74e-05 | 2.00e-01 | 0.0875 |
132949 | AASDH | P2T-E | Human | Esophagus | ESCC | 4.99e-21 | 4.00e-01 | 0.1177 |
132949 | AASDH | P4T-E | Human | Esophagus | ESCC | 2.44e-15 | 3.46e-01 | 0.1323 |
132949 | AASDH | P5T-E | Human | Esophagus | ESCC | 1.72e-06 | 9.92e-02 | 0.1327 |
132949 | AASDH | P8T-E | Human | Esophagus | ESCC | 4.98e-15 | 3.17e-01 | 0.0889 |
132949 | AASDH | P10T-E | Human | Esophagus | ESCC | 1.49e-09 | 1.35e-01 | 0.116 |
132949 | AASDH | P11T-E | Human | Esophagus | ESCC | 8.96e-03 | 1.22e-01 | 0.1426 |
132949 | AASDH | P12T-E | Human | Esophagus | ESCC | 1.61e-15 | 3.23e-01 | 0.1122 |
132949 | AASDH | P15T-E | Human | Esophagus | ESCC | 1.03e-09 | 1.23e-01 | 0.1149 |
132949 | AASDH | P16T-E | Human | Esophagus | ESCC | 1.51e-20 | 3.34e-01 | 0.1153 |
132949 | AASDH | P20T-E | Human | Esophagus | ESCC | 3.94e-04 | 9.31e-02 | 0.1124 |
132949 | AASDH | P21T-E | Human | Esophagus | ESCC | 6.25e-20 | 3.52e-01 | 0.1617 |
132949 | AASDH | P22T-E | Human | Esophagus | ESCC | 6.75e-18 | 2.28e-01 | 0.1236 |
132949 | AASDH | P23T-E | Human | Esophagus | ESCC | 2.45e-03 | 9.31e-02 | 0.108 |
132949 | AASDH | P24T-E | Human | Esophagus | ESCC | 5.52e-04 | 8.89e-02 | 0.1287 |
132949 | AASDH | P26T-E | Human | Esophagus | ESCC | 1.16e-12 | 2.95e-01 | 0.1276 |
132949 | AASDH | P27T-E | Human | Esophagus | ESCC | 4.81e-07 | 2.26e-01 | 0.1055 |
132949 | AASDH | P28T-E | Human | Esophagus | ESCC | 3.86e-20 | 5.09e-01 | 0.1149 |
132949 | AASDH | P30T-E | Human | Esophagus | ESCC | 1.12e-11 | 3.39e-01 | 0.137 |
Page: 1 2 3 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:00086525 | Esophagus | ESCC | cellular amino acid biosynthetic process | 51/8552 | 76/18723 | 1.30e-04 | 8.88e-04 | 51 |
GO:00067671 | Esophagus | ESCC | water-soluble vitamin metabolic process | 41/8552 | 59/18723 | 1.84e-04 | 1.17e-03 | 41 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00067661 | Esophagus | ESCC | vitamin metabolic process | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:19016075 | Esophagus | ESCC | alpha-amino acid biosynthetic process | 45/8552 | 68/18723 | 5.13e-04 | 2.84e-03 | 45 |
GO:00090674 | Esophagus | ESCC | aspartate family amino acid biosynthetic process | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:001605312 | Liver | Cirrhotic | organic acid biosynthetic process | 139/4634 | 316/18723 | 4.28e-14 | 3.83e-12 | 139 |
GO:004639412 | Liver | Cirrhotic | carboxylic acid biosynthetic process | 137/4634 | 314/18723 | 1.40e-13 | 1.14e-11 | 137 |
GO:19016051 | Liver | Cirrhotic | alpha-amino acid metabolic process | 82/4634 | 195/18723 | 7.72e-08 | 2.30e-06 | 82 |
GO:000652011 | Liver | Cirrhotic | cellular amino acid metabolic process | 103/4634 | 284/18723 | 8.88e-06 | 1.30e-04 | 103 |
GO:00086521 | Liver | Cirrhotic | cellular amino acid biosynthetic process | 36/4634 | 76/18723 | 1.55e-05 | 2.11e-04 | 36 |
GO:19016071 | Liver | Cirrhotic | alpha-amino acid biosynthetic process | 33/4634 | 68/18723 | 1.84e-05 | 2.49e-04 | 33 |
GO:000657511 | Liver | Cirrhotic | cellular modified amino acid metabolic process | 70/4634 | 188/18723 | 9.04e-05 | 9.69e-04 | 70 |
GO:00090661 | Liver | Cirrhotic | aspartate family amino acid metabolic process | 21/4634 | 49/18723 | 4.13e-03 | 2.21e-02 | 21 |
GO:00090671 | Liver | Cirrhotic | aspartate family amino acid biosynthetic process | 11/4634 | 21/18723 | 5.89e-03 | 2.95e-02 | 11 |
GO:001605321 | Liver | HCC | organic acid biosynthetic process | 200/7958 | 316/18723 | 5.24e-14 | 3.22e-12 | 200 |
GO:004639421 | Liver | HCC | carboxylic acid biosynthetic process | 198/7958 | 314/18723 | 1.19e-13 | 6.78e-12 | 198 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AASDH | SNV | Missense_Mutation | c.537N>C | p.Lys179Asn | p.K179N | Q4L235 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-EJ-7791-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | |
AASDH | SNV | Missense_Mutation | c.526N>G | p.Asn176Asp | p.N176D | Q4L235 | protein_coding | tolerated(0.67) | benign(0.062) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
AASDH | SNV | Missense_Mutation | c.1202N>C | p.Val401Ala | p.V401A | Q4L235 | protein_coding | tolerated(0.07) | probably_damaging(0.916) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
AASDH | SNV | Missense_Mutation | c.1049C>T | p.Ser350Leu | p.S350L | Q4L235 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D7-6528-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AASDH | SNV | Missense_Mutation | c.2581A>G | p.Thr861Ala | p.T861A | Q4L235 | protein_coding | tolerated(1) | benign(0.007) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AASDH | SNV | Missense_Mutation | rs189185200 | c.1058N>T | p.Ala353Val | p.A353V | Q4L235 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HF-7133-01 | Stomach | stomach adenocarcinoma | Female | Unknown | III/IV | Chemotherapy | epirubicin | SD |
AASDH | SNV | Missense_Mutation | novel | c.2797A>G | p.Lys933Glu | p.K933E | Q4L235 | protein_coding | tolerated(0.06) | benign(0.01) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
AASDH | insertion | Frame_Shift_Ins | novel | c.391_392insTGATA | p.Thr131MetfsTer11 | p.T131Mfs*11 | Q4L235 | protein_coding | TCGA-CG-5725-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | PD | ||
AASDH | SNV | Missense_Mutation | c.2125N>C | p.Asp709His | p.D709H | Q4L235 | protein_coding | deleterious(0.04) | possibly_damaging(0.707) | TCGA-FY-A3R9-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Hormone Therapy | levothyroxine | SD | |
AASDH | insertion | Frame_Shift_Ins | novel | c.2066_2067insCATTT | p.Leu690IlefsTer3 | p.L690Ifs*3 | Q4L235 | protein_coding | TCGA-EL-A3ZN-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |