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Gene: ZNF84 |
Gene summary for ZNF84 |
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Gene information | Species | Human | Gene symbol | ZNF84 | Gene ID | 7637 |
Gene name | zinc finger protein 84 | |
Gene Alias | HPF2 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P51523 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7637 | ZNF84 | LZE4T | Human | Esophagus | ESCC | 2.04e-07 | 1.52e-01 | 0.0811 |
7637 | ZNF84 | LZE7T | Human | Esophagus | ESCC | 1.98e-03 | 3.96e-01 | 0.0667 |
7637 | ZNF84 | LZE22T | Human | Esophagus | ESCC | 2.46e-02 | 3.12e-01 | 0.068 |
7637 | ZNF84 | LZE24T | Human | Esophagus | ESCC | 1.31e-07 | 2.22e-01 | 0.0596 |
7637 | ZNF84 | P1T-E | Human | Esophagus | ESCC | 3.01e-05 | 2.27e-01 | 0.0875 |
7637 | ZNF84 | P2T-E | Human | Esophagus | ESCC | 3.59e-46 | 7.58e-01 | 0.1177 |
7637 | ZNF84 | P4T-E | Human | Esophagus | ESCC | 1.25e-22 | 5.40e-01 | 0.1323 |
7637 | ZNF84 | P5T-E | Human | Esophagus | ESCC | 5.29e-16 | 2.40e-01 | 0.1327 |
7637 | ZNF84 | P8T-E | Human | Esophagus | ESCC | 3.47e-25 | 3.82e-01 | 0.0889 |
7637 | ZNF84 | P9T-E | Human | Esophagus | ESCC | 7.02e-03 | 1.25e-01 | 0.1131 |
7637 | ZNF84 | P10T-E | Human | Esophagus | ESCC | 1.27e-37 | 6.17e-01 | 0.116 |
7637 | ZNF84 | P11T-E | Human | Esophagus | ESCC | 1.69e-10 | 3.90e-01 | 0.1426 |
7637 | ZNF84 | P12T-E | Human | Esophagus | ESCC | 2.22e-23 | 4.27e-01 | 0.1122 |
7637 | ZNF84 | P15T-E | Human | Esophagus | ESCC | 1.88e-13 | 3.60e-01 | 0.1149 |
7637 | ZNF84 | P16T-E | Human | Esophagus | ESCC | 5.42e-22 | 4.04e-01 | 0.1153 |
7637 | ZNF84 | P17T-E | Human | Esophagus | ESCC | 1.20e-03 | 1.72e-01 | 0.1278 |
7637 | ZNF84 | P19T-E | Human | Esophagus | ESCC | 2.73e-02 | 2.00e-01 | 0.1662 |
7637 | ZNF84 | P21T-E | Human | Esophagus | ESCC | 1.02e-21 | 2.91e-01 | 0.1617 |
7637 | ZNF84 | P22T-E | Human | Esophagus | ESCC | 2.00e-17 | 3.36e-01 | 0.1236 |
7637 | ZNF84 | P23T-E | Human | Esophagus | ESCC | 2.04e-10 | 2.53e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF84 | ECM | Thyroid | Healthy | MEGF6,ZNF629,UBE2D4, etc. | 4.42e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF84 | SNV | Missense_Mutation | novel | c.229N>A | p.Asp77Asn | p.D77N | P51523 | protein_coding | tolerated(0.69) | benign(0) | TCGA-56-8307-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF84 | SNV | Missense_Mutation | novel | c.985N>T | p.Ser329Cys | p.S329C | P51523 | protein_coding | deleterious(0.05) | benign(0.398) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF84 | SNV | Missense_Mutation | novel | c.1681N>G | p.His561Asp | p.H561D | P51523 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF84 | SNV | Missense_Mutation | novel | c.1238G>T | p.Arg413Ile | p.R413I | P51523 | protein_coding | tolerated(0.21) | benign(0.26) | TCGA-58-8387-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF84 | SNV | Missense_Mutation | novel | c.1307G>T | p.Cys436Phe | p.C436F | P51523 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-60-2714-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
ZNF84 | SNV | Missense_Mutation | novel | c.1567N>A | p.Ala523Thr | p.A523T | P51523 | protein_coding | tolerated(0.18) | possibly_damaging(0.506) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
ZNF84 | SNV | Missense_Mutation | novel | c.1864A>G | p.Thr622Ala | p.T622A | P51523 | protein_coding | deleterious(0.04) | possibly_damaging(0.623) | TCGA-66-2800-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZNF84 | SNV | Missense_Mutation | novel | c.264G>A | p.Met88Ile | p.M88I | P51523 | protein_coding | tolerated(0.67) | benign(0) | TCGA-90-7964-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF84 | SNV | Missense_Mutation | novel | c.262A>G | p.Met88Val | p.M88V | P51523 | protein_coding | tolerated(0.26) | benign(0) | TCGA-BA-A6DD-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF84 | SNV | Missense_Mutation | novel | c.1681N>G | p.His561Asp | p.H561D | P51523 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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