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Gene: ZNF790 |
Gene summary for ZNF790 |
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Gene information | Species | Human | Gene symbol | ZNF790 | Gene ID | 388536 |
Gene name | zinc finger protein 790 | |
Gene Alias | ZNF790 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B4DMI3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388536 | ZNF790 | PTC01 | Human | Thyroid | PTC | 1.21e-04 | 8.58e-02 | 0.1899 |
388536 | ZNF790 | PTC04 | Human | Thyroid | PTC | 1.09e-02 | 8.82e-02 | 0.1927 |
388536 | ZNF790 | PTC05 | Human | Thyroid | PTC | 2.19e-08 | 2.07e-01 | 0.2065 |
388536 | ZNF790 | PTC06 | Human | Thyroid | PTC | 2.62e-11 | 1.45e-01 | 0.2057 |
388536 | ZNF790 | PTC07 | Human | Thyroid | PTC | 2.74e-06 | 1.66e-01 | 0.2044 |
388536 | ZNF790 | ATC13 | Human | Thyroid | ATC | 9.49e-85 | 1.44e+00 | 0.34 |
388536 | ZNF790 | ATC4 | Human | Thyroid | ATC | 5.70e-07 | 9.98e-02 | 0.34 |
388536 | ZNF790 | ATC5 | Human | Thyroid | ATC | 2.90e-93 | 1.51e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF790 | SNV | Missense_Mutation | c.905G>T | p.Arg302Ile | p.R302I | Q6PG37 | protein_coding | tolerated(0.1) | possibly_damaging(0.521) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ZNF790 | SNV | Missense_Mutation | c.97N>A | p.Val33Met | p.V33M | Q6PG37 | protein_coding | deleterious(0.05) | possibly_damaging(0.579) | TCGA-CG-5724-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD | |
ZNF790 | SNV | Missense_Mutation | c.636N>C | p.Glu212Asp | p.E212D | Q6PG37 | protein_coding | tolerated(0.22) | benign(0.012) | TCGA-D7-A4YU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | SD | |
ZNF790 | SNV | Missense_Mutation | c.257A>C | p.Lys86Thr | p.K86T | Q6PG37 | protein_coding | tolerated(0.05) | possibly_damaging(0.636) | TCGA-R5-A805-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF790 | SNV | Missense_Mutation | c.1400G>T | p.Arg467Leu | p.R467L | Q6PG37 | protein_coding | tolerated(0.25) | benign(0.232) | TCGA-VQ-A8P3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR | |
ZNF790 | SNV | Missense_Mutation | novel | c.1120N>T | p.Ala374Ser | p.A374S | Q6PG37 | protein_coding | tolerated(0.18) | possibly_damaging(0.46) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
ZNF790 | insertion | Frame_Shift_Ins | novel | c.1572_1573insTCCCATAGTCTGTCCATTCA | p.Gln525SerfsTer135 | p.Q525Sfs*135 | Q6PG37 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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