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Gene: ZNF609 |
Gene summary for ZNF609 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF609 | Gene ID | 23060 |
Gene name | zinc finger protein 609 | |
Gene Alias | ZNF609 | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0001764 | UniProtAcc | O15014 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23060 | ZNF609 | CCI_1 | Human | Cervix | CC | 1.23e-06 | 1.11e+00 | 0.528 |
23060 | ZNF609 | CCI_2 | Human | Cervix | CC | 2.55e-10 | 1.53e+00 | 0.5249 |
23060 | ZNF609 | CCI_3 | Human | Cervix | CC | 3.37e-15 | 1.07e+00 | 0.516 |
23060 | ZNF609 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.58e-03 | -3.13e-01 | 0.0155 |
23060 | ZNF609 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.40e-04 | 5.28e-01 | -0.059 |
23060 | ZNF609 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.06e-02 | -2.72e-01 | 0.294 |
23060 | ZNF609 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.62e-03 | 9.11e-01 | 0.3487 |
23060 | ZNF609 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.97e-02 | -2.64e-01 | 0.3859 |
23060 | ZNF609 | A002-C-010 | Human | Colorectum | FAP | 3.09e-02 | -6.80e-02 | 0.242 |
23060 | ZNF609 | A001-C-207 | Human | Colorectum | FAP | 3.08e-02 | -1.97e-01 | 0.1278 |
23060 | ZNF609 | A015-C-203 | Human | Colorectum | FAP | 6.42e-35 | -3.99e-01 | -0.1294 |
23060 | ZNF609 | A015-C-204 | Human | Colorectum | FAP | 7.15e-07 | -3.85e-01 | -0.0228 |
23060 | ZNF609 | A014-C-040 | Human | Colorectum | FAP | 1.84e-06 | -4.61e-01 | -0.1184 |
23060 | ZNF609 | A002-C-201 | Human | Colorectum | FAP | 2.72e-11 | -2.14e-01 | 0.0324 |
23060 | ZNF609 | A002-C-203 | Human | Colorectum | FAP | 6.43e-03 | -6.31e-02 | 0.2786 |
23060 | ZNF609 | A001-C-119 | Human | Colorectum | FAP | 1.27e-09 | 1.11e-01 | -0.1557 |
23060 | ZNF609 | A001-C-108 | Human | Colorectum | FAP | 2.65e-15 | -1.89e-01 | -0.0272 |
23060 | ZNF609 | A002-C-205 | Human | Colorectum | FAP | 7.52e-25 | -3.35e-01 | -0.1236 |
23060 | ZNF609 | A015-C-006 | Human | Colorectum | FAP | 1.50e-14 | -3.53e-01 | -0.0994 |
23060 | ZNF609 | A015-C-106 | Human | Colorectum | FAP | 2.38e-10 | -2.26e-01 | -0.0511 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00075173 | Cervix | CC | muscle organ development | 58/2311 | 327/18723 | 2.73e-03 | 1.85e-02 | 58 |
GO:20012241 | Cervix | CC | positive regulation of neuron migration | 6/2311 | 16/18723 | 9.35e-03 | 4.66e-02 | 6 |
GO:00075174 | Endometrium | AEH | muscle organ development | 60/2100 | 327/18723 | 8.19e-05 | 1.22e-03 | 60 |
GO:00017642 | Endometrium | AEH | neuron migration | 31/2100 | 156/18723 | 1.08e-03 | 9.46e-03 | 31 |
GO:000751712 | Endometrium | EEC | muscle organ development | 59/2168 | 327/18723 | 3.49e-04 | 3.85e-03 | 59 |
GO:00017641 | Endometrium | EEC | neuron migration | 33/2168 | 156/18723 | 4.17e-04 | 4.38e-03 | 33 |
GO:2001224 | Liver | HCC | positive regulation of neuron migration | 14/7958 | 16/18723 | 2.73e-04 | 1.98e-03 | 14 |
GO:0001764 | Lung | IAC | neuron migration | 31/2061 | 156/18723 | 7.89e-04 | 1.02e-02 | 31 |
GO:0007517 | Lung | AAH | muscle organ development | 22/613 | 327/18723 | 1.20e-03 | 3.33e-02 | 22 |
GO:00075176 | Oral cavity | EOLP | muscle organ development | 57/2218 | 327/18723 | 1.76e-03 | 1.15e-02 | 57 |
GO:000751714 | Oral cavity | NEOLP | muscle organ development | 56/2005 | 327/18723 | 2.65e-04 | 2.70e-03 | 56 |
GO:00017643 | Oral cavity | NEOLP | neuron migration | 31/2005 | 156/18723 | 4.96e-04 | 4.40e-03 | 31 |
GO:00075175 | Prostate | BPH | muscle organ development | 71/3107 | 327/18723 | 9.00e-03 | 3.84e-02 | 71 |
GO:000751713 | Prostate | Tumor | muscle organ development | 74/3246 | 327/18723 | 8.03e-03 | 3.54e-02 | 74 |
GO:000751716 | Thyroid | ATC | muscle organ development | 139/6293 | 327/18723 | 4.45e-04 | 2.64e-03 | 139 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF609 | SNV | Missense_Mutation | novel | c.678N>T | p.Leu226Phe | p.L226F | O15014 | protein_coding | deleterious(0.02) | possibly_damaging(0.839) | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
ZNF609 | SNV | Missense_Mutation | rs764206103 | c.554N>G | p.Val185Gly | p.V185G | O15014 | protein_coding | tolerated(0.37) | benign(0.085) | TCGA-60-2716-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
ZNF609 | SNV | Missense_Mutation | novel | c.310C>T | p.Pro104Ser | p.P104S | O15014 | protein_coding | tolerated(0.17) | benign(0) | TCGA-66-2768-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF609 | SNV | Missense_Mutation | c.34N>A | p.Gly12Arg | p.G12R | O15014 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-66-2795-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF609 | SNV | Missense_Mutation | novel | c.1379G>A | p.Ser460Asn | p.S460N | O15014 | protein_coding | tolerated(0.35) | possibly_damaging(0.882) | TCGA-77-8150-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ZNF609 | SNV | Missense_Mutation | novel | c.2876N>T | p.Ser959Leu | p.S959L | O15014 | protein_coding | tolerated(0.05) | probably_damaging(0.995) | TCGA-CN-5360-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
ZNF609 | SNV | Missense_Mutation | novel | c.2260N>C | p.Glu754Gln | p.E754Q | O15014 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZNF609 | SNV | Missense_Mutation | novel | c.982N>A | p.Val328Met | p.V328M | O15014 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ZNF609 | SNV | Missense_Mutation | rs776390142 | c.3487N>T | p.Arg1163Trp | p.R1163W | O15014 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ZNF609 | deletion | Frame_Shift_Del | novel | c.1235delG | p.Gly412AlafsTer39 | p.G412Afs*39 | O15014 | protein_coding | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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