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Gene: ZNF569 |
Gene summary for ZNF569 |
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Gene information | Species | Human | Gene symbol | ZNF569 | Gene ID | 148266 |
Gene name | zinc finger protein 569 | |
Gene Alias | ZAP1 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5MCW4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148266 | ZNF569 | ATC13 | Human | Thyroid | ATC | 3.35e-36 | 6.14e-01 | 0.34 |
148266 | ZNF569 | ATC5 | Human | Thyroid | ATC | 2.28e-36 | 6.89e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF569 | SNV | Missense_Mutation | c.572N>C | p.Cys191Ser | p.C191S | Q5MCW4 | protein_coding | deleterious(0.02) | benign(0.006) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF569 | SNV | Missense_Mutation | c.1791G>T | p.Met597Ile | p.M597I | Q5MCW4 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-55-1592-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF569 | SNV | Missense_Mutation | c.994N>T | p.Gly332Cys | p.G332C | Q5MCW4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
ZNF569 | SNV | Missense_Mutation | c.589N>A | p.Gln197Lys | p.Q197K | Q5MCW4 | protein_coding | tolerated(0.48) | benign(0.024) | TCGA-22-4604-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Targeted Molecular therapy | iressa | PD | |
ZNF569 | SNV | Missense_Mutation | novel | c.1898C>A | p.Pro633His | p.P633H | Q5MCW4 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF569 | SNV | Missense_Mutation | c.632N>C | p.Glu211Ala | p.E211A | Q5MCW4 | protein_coding | deleterious(0.01) | benign(0.083) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ZNF569 | SNV | Missense_Mutation | c.403N>C | p.Asn135His | p.N135H | Q5MCW4 | protein_coding | deleterious(0.02) | benign(0.161) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD | |
ZNF569 | SNV | Missense_Mutation | c.2040N>G | p.His680Gln | p.H680Q | Q5MCW4 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-43-6143-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesVaccine | recmage3-as+as15 | SD | |
ZNF569 | SNV | Missense_Mutation | c.1853N>A | p.Ser618Asn | p.S618N | Q5MCW4 | protein_coding | tolerated(0.26) | possibly_damaging(0.878) | TCGA-66-2786-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF569 | SNV | Missense_Mutation | novel | c.764N>T | p.Ser255Leu | p.S255L | Q5MCW4 | protein_coding | deleterious(0.01) | benign(0.08) | TCGA-85-7950-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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