GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
GO:0032388110 | Esophagus | ESCC | positive regulation of intracellular transport | 152/8552 | 202/18723 | 7.89e-18 | 7.36e-16 | 152 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0046822110 | Esophagus | ESCC | regulation of nucleocytoplasmic transport | 88/8552 | 106/18723 | 1.88e-15 | 1.19e-13 | 88 |
GO:009031617 | Esophagus | ESCC | positive regulation of intracellular protein transport | 122/8552 | 160/18723 | 2.45e-15 | 1.49e-13 | 122 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:190018018 | Esophagus | ESCC | regulation of protein localization to nucleus | 102/8552 | 136/18723 | 2.84e-12 | 1.13e-10 | 102 |
GO:190018217 | Esophagus | ESCC | positive regulation of protein localization to nucleus | 70/8552 | 87/18723 | 2.63e-11 | 8.99e-10 | 70 |
GO:004682417 | Esophagus | ESCC | positive regulation of nucleocytoplasmic transport | 52/8552 | 62/18723 | 5.40e-10 | 1.38e-08 | 52 |
GO:005117014 | Esophagus | ESCC | import into nucleus | 111/8552 | 159/18723 | 5.69e-10 | 1.44e-08 | 111 |
GO:000660613 | Esophagus | ESCC | protein import into nucleus | 108/8552 | 155/18723 | 1.16e-09 | 2.77e-08 | 108 |
GO:190458914 | Esophagus | ESCC | regulation of protein import | 49/8552 | 63/18723 | 1.91e-07 | 2.97e-06 | 49 |
GO:190459116 | Esophagus | ESCC | positive regulation of protein import | 36/8552 | 43/18723 | 2.90e-07 | 4.20e-06 | 36 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZIC1 | SNV | Missense_Mutation | novel | c.461N>A | p.Ala154Glu | p.A154E | Q15915 | protein_coding | tolerated(0.05) | possibly_damaging(0.866) | TCGA-63-A5MY-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZIC1 | SNV | Missense_Mutation | rs545219481 | c.1329N>G | p.Asn443Lys | p.N443K | Q15915 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-66-2770-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZIC1 | SNV | Missense_Mutation | | c.1141N>G | p.Met381Val | p.M381V | Q15915 | protein_coding | deleterious(0) | benign(0.055) | TCGA-66-2783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | CR |
ZIC1 | SNV | Missense_Mutation | novel | c.1159T>A | p.Ser387Thr | p.S387T | Q15915 | protein_coding | tolerated(0.24) | benign(0) | TCGA-77-7465-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZIC1 | SNV | Missense_Mutation | rs765916669 | c.29C>A | p.Pro10Gln | p.P10Q | Q15915 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.829) | TCGA-77-8138-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZIC1 | SNV | Missense_Mutation | novel | c.439N>A | p.His147Asn | p.H147N | Q15915 | protein_coding | deleterious(0) | possibly_damaging(0.771) | TCGA-85-7950-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZIC1 | SNV | Missense_Mutation | novel | c.626G>T | p.Gly209Val | p.G209V | Q15915 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-85-8351-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
ZIC1 | SNV | Missense_Mutation | rs748870052 | c.178N>T | p.Gly60Cys | p.G60C | Q15915 | protein_coding | tolerated(0.1) | probably_damaging(0.996) | TCGA-92-7340-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZIC1 | SNV | Missense_Mutation | novel | c.663C>G | p.Ile221Met | p.I221M | Q15915 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
ZIC1 | SNV | Missense_Mutation | novel | c.331N>C | p.Ala111Pro | p.A111P | Q15915 | protein_coding | tolerated(0.23) | possibly_damaging(0.885) | TCGA-98-A53I-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | navelbine | SD |