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Gene: ZEB1 |
Gene summary for ZEB1 |
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Gene information | Species | Human | Gene symbol | ZEB1 | Gene ID | 6935 |
Gene name | zinc finger E-box binding homeobox 1 | |
Gene Alias | AREB6 | |
Cytomap | 10p11.22 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B2RBI8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6935 | ZEB1 | NAFLD1 | Human | Liver | NAFLD | 9.87e-08 | 8.87e-01 | -0.04 |
6935 | ZEB1 | HCC1_Meng | Human | Liver | HCC | 3.36e-31 | -1.25e-01 | 0.0246 |
6935 | ZEB1 | HCC2_Meng | Human | Liver | HCC | 8.04e-04 | -1.90e-01 | 0.0107 |
6935 | ZEB1 | cirrhotic2 | Human | Liver | Cirrhotic | 9.53e-05 | -1.85e-01 | 0.0201 |
6935 | ZEB1 | HCC1 | Human | Liver | HCC | 5.23e-03 | 4.56e+00 | 0.5336 |
6935 | ZEB1 | HCC2 | Human | Liver | HCC | 6.96e-04 | 2.40e+00 | 0.5341 |
6935 | ZEB1 | Pt13.b | Human | Liver | HCC | 8.90e-03 | -2.83e-02 | 0.0251 |
6935 | ZEB1 | S014 | Human | Liver | HCC | 4.40e-11 | 4.60e-01 | 0.2254 |
6935 | ZEB1 | S015 | Human | Liver | HCC | 1.52e-09 | 5.51e-01 | 0.2375 |
6935 | ZEB1 | S016 | Human | Liver | HCC | 4.25e-06 | 3.11e-01 | 0.2243 |
6935 | ZEB1 | S028 | Human | Liver | HCC | 1.09e-04 | 2.78e-01 | 0.2503 |
6935 | ZEB1 | S029 | Human | Liver | HCC | 7.89e-04 | 3.84e-01 | 0.2581 |
6935 | ZEB1 | C43 | Human | Oral cavity | OSCC | 6.29e-04 | -3.27e-01 | 0.1704 |
6935 | ZEB1 | C46 | Human | Oral cavity | OSCC | 9.80e-05 | -3.45e-01 | 0.1673 |
6935 | ZEB1 | C08 | Human | Oral cavity | OSCC | 3.02e-04 | -3.23e-01 | 0.1919 |
6935 | ZEB1 | EOLP-1 | Human | Oral cavity | EOLP | 1.69e-19 | 5.60e-01 | -0.0202 |
6935 | ZEB1 | NEOLP-1 | Human | Oral cavity | NEOLP | 3.65e-19 | 6.20e-01 | -0.0194 |
6935 | ZEB1 | NEOLP-2 | Human | Oral cavity | NEOLP | 2.00e-19 | 5.61e-01 | -0.0196 |
6935 | ZEB1 | NEOLP-3 | Human | Oral cavity | NEOLP | 5.40e-25 | 6.53e-01 | -0.0191 |
6935 | ZEB1 | SYSMH1 | Human | Oral cavity | OSCC | 1.05e-04 | -3.30e-01 | 0.1127 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00031586 | Liver | Cirrhotic | endothelium development | 49/4634 | 136/18723 | 2.14e-03 | 1.32e-02 | 49 |
GO:00454465 | Liver | Cirrhotic | endothelial cell differentiation | 43/4634 | 118/18723 | 3.03e-03 | 1.72e-02 | 43 |
GO:000315816 | Oral cavity | OSCC | endothelium development | 71/7305 | 136/18723 | 1.18e-03 | 5.99e-03 | 71 |
GO:00454469 | Oral cavity | OSCC | endothelial cell differentiation | 61/7305 | 118/18723 | 3.40e-03 | 1.44e-02 | 61 |
GO:000315817 | Oral cavity | EOLP | endothelium development | 28/2218 | 136/18723 | 2.37e-03 | 1.45e-02 | 28 |
GO:004544615 | Oral cavity | EOLP | endothelial cell differentiation | 25/2218 | 118/18723 | 2.63e-03 | 1.59e-02 | 25 |
GO:000315823 | Oral cavity | NEOLP | endothelium development | 33/2005 | 136/18723 | 4.94e-06 | 1.04e-04 | 33 |
GO:00308566 | Oral cavity | NEOLP | regulation of epithelial cell differentiation | 33/2005 | 154/18723 | 7.47e-05 | 9.67e-04 | 33 |
GO:004544622 | Oral cavity | NEOLP | endothelial cell differentiation | 27/2005 | 118/18723 | 1.03e-04 | 1.24e-03 | 27 |
GO:0003158111 | Thyroid | PTC | endothelium development | 62/5968 | 136/18723 | 5.45e-04 | 3.48e-03 | 62 |
GO:004544619 | Thyroid | PTC | endothelial cell differentiation | 55/5968 | 118/18723 | 5.64e-04 | 3.59e-03 | 55 |
GO:000315825 | Thyroid | ATC | endothelium development | 66/6293 | 136/18723 | 2.16e-04 | 1.42e-03 | 66 |
GO:004544623 | Thyroid | ATC | endothelial cell differentiation | 56/6293 | 118/18723 | 1.23e-03 | 6.44e-03 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0521524 | Oral cavity | EOLP | Prostate cancer | 31/1218 | 97/8465 | 7.90e-06 | 4.73e-05 | 2.79e-05 | 31 |
hsa0521534 | Oral cavity | EOLP | Prostate cancer | 31/1218 | 97/8465 | 7.90e-06 | 4.73e-05 | 2.79e-05 | 31 |
hsa0521542 | Oral cavity | NEOLP | Prostate cancer | 28/1112 | 97/8465 | 3.15e-05 | 2.57e-04 | 1.62e-04 | 28 |
hsa0521552 | Oral cavity | NEOLP | Prostate cancer | 28/1112 | 97/8465 | 3.15e-05 | 2.57e-04 | 1.62e-04 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZEB1 | SNV | Missense_Mutation | rs202145455 | c.2591N>G | p.Pro864Arg | p.P864R | P37275 | protein_coding | tolerated(0.57) | benign(0.368) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
ZEB1 | SNV | Missense_Mutation | c.1546N>C | p.Lys516Gln | p.K516Q | P37275 | protein_coding | tolerated(0.23) | probably_damaging(0.922) | TCGA-35-4123-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZEB1 | SNV | Missense_Mutation | c.1312G>T | p.Ala438Ser | p.A438S | P37275 | protein_coding | tolerated(0.33) | benign(0.03) | TCGA-38-4632-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | gemcitabine | PD | |
ZEB1 | SNV | Missense_Mutation | c.2383N>T | p.Pro795Ser | p.P795S | P37275 | protein_coding | deleterious(0.04) | benign(0.194) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZEB1 | SNV | Missense_Mutation | c.2567N>C | p.Glu856Ala | p.E856A | P37275 | protein_coding | tolerated(0.37) | possibly_damaging(0.874) | TCGA-44-7671-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZEB1 | SNV | Missense_Mutation | c.56N>G | p.Asn19Ser | p.N19S | P37275 | protein_coding | tolerated(0.31) | benign(0.185) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
ZEB1 | SNV | Missense_Mutation | c.154G>C | p.Asp52His | p.D52H | P37275 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZEB1 | SNV | Missense_Mutation | c.1481N>G | p.Lys494Arg | p.K494R | P37275 | protein_coding | deleterious(0.05) | possibly_damaging(0.906) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZEB1 | SNV | Missense_Mutation | novel | c.1391N>A | p.Pro464His | p.P464H | P37275 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
ZEB1 | SNV | Missense_Mutation | c.2531N>G | p.Tyr844Cys | p.Y844C | P37275 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-55-1592-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6935 | ZEB1 | TRANSCRIPTION FACTOR, DRUG RESISTANCE | DOXORUBICIN | DOXORUBICIN | 24013721 | |
6935 | ZEB1 | TRANSCRIPTION FACTOR, DRUG RESISTANCE | OXALIPLATIN | OXALIPLATIN | 29151941 | |
6935 | ZEB1 | TRANSCRIPTION FACTOR, DRUG RESISTANCE | SALINOMYCIN | SALINOMYCIN | 24013721 |
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