Tissue | Expression Dynamics | Abbreviation |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00459264 | Endometrium | AEH | negative regulation of growth | 47/2100 | 249/18723 | 2.36e-04 | 2.84e-03 | 47 |
GO:00486387 | Endometrium | AEH | regulation of developmental growth | 58/2100 | 330/18723 | 3.45e-04 | 3.80e-03 | 58 |
GO:0035265 | Endometrium | AEH | organ growth | 33/2100 | 178/18723 | 2.53e-03 | 1.87e-02 | 33 |
GO:004592611 | Endometrium | EEC | negative regulation of growth | 48/2168 | 249/18723 | 2.58e-04 | 2.98e-03 | 48 |
GO:004863812 | Endometrium | EEC | regulation of developmental growth | 58/2168 | 330/18723 | 7.65e-04 | 7.16e-03 | 58 |
GO:00352651 | Endometrium | EEC | organ growth | 32/2168 | 178/18723 | 7.54e-03 | 4.22e-02 | 32 |
GO:00459267 | Esophagus | ESCC | negative regulation of growth | 148/8552 | 249/18723 | 7.88e-06 | 7.73e-05 | 148 |
GO:00353297 | Esophagus | ESCC | hippo signaling | 26/8552 | 40/18723 | 1.08e-02 | 3.66e-02 | 26 |
GO:0035329 | Liver | NAFLD | hippo signaling | 10/1882 | 40/18723 | 5.20e-03 | 4.05e-02 | 10 |
GO:00486384 | Liver | NAFLD | regulation of developmental growth | 48/1882 | 330/18723 | 5.74e-03 | 4.37e-02 | 48 |
GO:0035331 | Liver | NAFLD | negative regulation of hippo signaling | 5/1882 | 13/18723 | 6.58e-03 | 4.69e-02 | 5 |
GO:00353311 | Liver | Cirrhotic | negative regulation of hippo signaling | 8/4634 | 13/18723 | 5.27e-03 | 2.70e-02 | 8 |
GO:00459263 | Liver | HCC | negative regulation of growth | 129/7958 | 249/18723 | 1.81e-03 | 9.37e-03 | 129 |
GO:00353312 | Liver | HCC | negative regulation of hippo signaling | 10/7958 | 13/18723 | 1.28e-02 | 4.61e-02 | 10 |
GO:00486385 | Lung | IAC | regulation of developmental growth | 59/2061 | 330/18723 | 1.17e-04 | 2.22e-03 | 59 |
GO:00353313 | Lung | IAC | negative regulation of hippo signaling | 6/2061 | 13/18723 | 1.53e-03 | 1.62e-02 | 6 |
GO:00353293 | Lung | IAC | hippo signaling | 11/2061 | 40/18723 | 3.13e-03 | 2.75e-02 | 11 |
GO:0035330 | Lung | IAC | regulation of hippo signaling | 7/2061 | 21/18723 | 5.59e-03 | 4.12e-02 | 7 |
GO:004863811 | Lung | AIS | regulation of developmental growth | 55/1849 | 330/18723 | 7.63e-05 | 1.95e-03 | 55 |
GO:00353291 | Lung | AIS | hippo signaling | 10/1849 | 40/18723 | 4.59e-03 | 4.03e-02 | 10 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WWC2 | SNV | Missense_Mutation | | c.750N>T | p.Gln250His | p.Q250H | Q6AWC2 | protein_coding | deleterious(0.01) | possibly_damaging(0.641) | TCGA-75-6206-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
WWC2 | SNV | Missense_Mutation | novel | c.3002G>A | p.Arg1001His | p.R1001H | Q6AWC2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-22-5483-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD |
WWC2 | SNV | Missense_Mutation | | c.1370N>C | p.Ser457Thr | p.S457T | Q6AWC2 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-37-3783-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
WWC2 | SNV | Missense_Mutation | novel | c.3309N>T | p.Gln1103His | p.Q1103H | Q6AWC2 | protein_coding | tolerated(0.32) | benign(0.396) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
WWC2 | SNV | Missense_Mutation | rs752532710 | c.1549N>T | p.Pro517Ser | p.P517S | Q6AWC2 | protein_coding | tolerated(0.55) | benign(0.071) | TCGA-56-8308-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | SD |
WWC2 | SNV | Missense_Mutation | rs574309917 | c.1343C>T | p.Ser448Leu | p.S448L | Q6AWC2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-56-8629-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
WWC2 | SNV | Missense_Mutation | novel | c.2015N>T | p.Gly672Val | p.G672V | Q6AWC2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-66-2727-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WWC2 | SNV | Missense_Mutation | novel | c.2360N>G | p.Asp787Gly | p.D787G | Q6AWC2 | protein_coding | tolerated(0.07) | possibly_damaging(0.468) | TCGA-85-8288-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WWC2 | SNV | Missense_Mutation | novel | c.3227N>T | p.Ser1076Phe | p.S1076F | Q6AWC2 | protein_coding | deleterious(0.04) | possibly_damaging(0.54) | TCGA-85-8584-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WWC2 | SNV | Missense_Mutation | novel | c.1972N>T | p.Val658Leu | p.V658L | Q6AWC2 | protein_coding | deleterious(0.03) | possibly_damaging(0.882) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |