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Gene: WRN |
Gene summary for WRN |
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Gene information | Species | Human | Gene symbol | WRN | Gene ID | 7486 |
Gene name | WRN RecQ like helicase | |
Gene Alias | RECQ3 | |
Cytomap | 8p12 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | Q14191 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7486 | WRN | CCI_2 | Human | Cervix | CC | 4.58e-05 | 9.44e-01 | 0.5249 |
7486 | WRN | CCI_3 | Human | Cervix | CC | 2.40e-10 | 7.16e-01 | 0.516 |
7486 | WRN | HTA12-23-1 | Human | Pancreas | PDAC | 1.24e-03 | 4.83e-01 | 0.3405 |
7486 | WRN | HTA12-25-1 | Human | Pancreas | PDAC | 2.95e-02 | 3.27e-01 | 0.313 |
7486 | WRN | HTA12-26-1 | Human | Pancreas | PDAC | 2.64e-12 | 6.07e-01 | 0.3728 |
7486 | WRN | HTA12-29-1 | Human | Pancreas | PDAC | 2.20e-26 | 6.13e-01 | 0.3722 |
7486 | WRN | 048752_1579-all-cells | Human | Prostate | BPH | 2.12e-22 | 5.43e-01 | 0.1008 |
7486 | WRN | 052095_1628-all-cells | Human | Prostate | BPH | 8.93e-21 | 5.34e-01 | 0.1032 |
7486 | WRN | 052097_1595-all-cells | Human | Prostate | BPH | 4.63e-20 | 5.95e-01 | 0.0972 |
7486 | WRN | 052099_1652-all-cells | Human | Prostate | BPH | 3.74e-09 | 4.32e-01 | 0.1038 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697910 | Cervix | CC | response to oxidative stress | 102/2311 | 446/18723 | 2.99e-10 | 4.36e-08 | 102 |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00075689 | Cervix | CC | aging | 75/2311 | 339/18723 | 2.75e-07 | 1.13e-05 | 75 |
GO:00316689 | Cervix | CC | cellular response to extracellular stimulus | 59/2311 | 246/18723 | 3.03e-07 | 1.24e-05 | 59 |
GO:003166710 | Cervix | CC | response to nutrient levels | 92/2311 | 474/18723 | 5.80e-06 | 1.42e-04 | 92 |
GO:00712148 | Cervix | CC | cellular response to abiotic stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:01040048 | Cervix | CC | cellular response to environmental stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:00092678 | Cervix | CC | cellular response to starvation | 39/2311 | 156/18723 | 1.04e-05 | 2.32e-04 | 39 |
GO:00425948 | Cervix | CC | response to starvation | 46/2311 | 197/18723 | 1.24e-05 | 2.59e-04 | 46 |
GO:00316698 | Cervix | CC | cellular response to nutrient levels | 49/2311 | 215/18723 | 1.32e-05 | 2.68e-04 | 49 |
GO:00075695 | Cervix | CC | cell aging | 34/2311 | 132/18723 | 1.92e-05 | 3.53e-04 | 34 |
GO:00714798 | Cervix | CC | cellular response to ionizing radiation | 22/2311 | 72/18723 | 3.47e-05 | 5.60e-04 | 22 |
GO:00093149 | Cervix | CC | response to radiation | 86/2311 | 456/18723 | 3.50e-05 | 5.63e-04 | 86 |
GO:00714786 | Cervix | CC | cellular response to radiation | 41/2311 | 186/18723 | 1.41e-04 | 1.71e-03 | 41 |
GO:00102126 | Cervix | CC | response to ionizing radiation | 34/2311 | 148/18723 | 2.23e-04 | 2.53e-03 | 34 |
GO:00094112 | Cervix | CC | response to UV | 33/2311 | 149/18723 | 5.51e-04 | 5.29e-03 | 33 |
GO:00510528 | Cervix | CC | regulation of DNA metabolic process | 65/2311 | 359/18723 | 9.25e-04 | 7.84e-03 | 65 |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:00323923 | Cervix | CC | DNA geometric change | 21/2311 | 90/18723 | 2.71e-03 | 1.85e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WRN | SNV | Missense_Mutation | c.3124N>C | p.Ala1042Pro | p.A1042P | Q14191 | protein_coding | tolerated(0.12) | benign(0.276) | TCGA-05-4418-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
WRN | SNV | Missense_Mutation | novel | c.3495N>T | p.Gln1165His | p.Q1165H | Q14191 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
WRN | SNV | Missense_Mutation | novel | c.264A>T | p.Leu88Phe | p.L88F | Q14191 | protein_coding | deleterious(0.05) | benign(0.007) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WRN | SNV | Missense_Mutation | c.2525C>T | p.Pro842Leu | p.P842L | Q14191 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-2661-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WRN | SNV | Missense_Mutation | c.1452N>A | p.Ser484Arg | p.S484R | Q14191 | protein_coding | tolerated(0.22) | benign(0.012) | TCGA-44-2665-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Targeted Molecular therapy | bevacizumab | SD | |
WRN | SNV | Missense_Mutation | novel | c.847N>T | p.Ile283Phe | p.I283F | Q14191 | protein_coding | tolerated(0.05) | benign(0.023) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WRN | SNV | Missense_Mutation | c.3908N>C | p.Leu1303Ser | p.L1303S | Q14191 | protein_coding | deleterious(0.01) | benign(0.164) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
WRN | SNV | Missense_Mutation | rs758055295 | c.745N>A | p.Asp249Asn | p.D249N | Q14191 | protein_coding | tolerated(0.11) | benign(0.288) | TCGA-53-A4EZ-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
WRN | SNV | Missense_Mutation | novel | c.1264A>T | p.Thr422Ser | p.T422S | Q14191 | protein_coding | tolerated(0.49) | benign(0) | TCGA-55-8301-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PR |
WRN | SNV | Missense_Mutation | c.3824G>C | p.Ser1275Thr | p.S1275T | Q14191 | protein_coding | tolerated(0.43) | benign(0.03) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | NSC-7387 | CHEMBL119878 | ||
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | GNF-PF-4459 | CHEMBL585502 | ||
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | SJ000001516 | CHEMBL592316 | ||
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | NSC-11437 | CHEMBL1814509 | ||
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | TCMDC-123916 | CHEMBL493863 | ||
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | NSC-720622 | CHEMBL1287980 | ||
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | UREA | UREA | 17312972 | |
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | NSC-348401 | CHEMBL515505 | ||
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | QUERCETIN DIHYDRATE | QUERCETIN DIHYDRATE | ||
7486 | WRN | CLINICALLY ACTIONABLE, DNA REPAIR, ENZYME | NANAOMYCIN | NANAOMYCIN |
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