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Gene: USP47 |
Gene summary for USP47 |
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Gene information | Species | Human | Gene symbol | USP47 | Gene ID | 55031 |
Gene name | ubiquitin specific peptidase 47 | |
Gene Alias | TRFP | |
Cytomap | 11p15.3 | |
Gene Type | protein-coding | GO ID | GO:0000086 | UniProtAcc | Q68D97 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55031 | USP47 | CCI_2 | Human | Cervix | CC | 5.49e-03 | 5.13e-01 | 0.5249 |
55031 | USP47 | CCI_3 | Human | Cervix | CC | 1.60e-03 | 5.47e-01 | 0.516 |
55031 | USP47 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.18e-16 | -6.56e-01 | 0.0155 |
55031 | USP47 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.48e-03 | -5.42e-01 | -0.1808 |
55031 | USP47 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.20e-08 | -7.41e-01 | -0.1207 |
55031 | USP47 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.07e-18 | -5.53e-01 | -0.1464 |
55031 | USP47 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.10e-15 | -4.79e-01 | -0.1001 |
55031 | USP47 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.35e-02 | -4.22e-01 | -0.059 |
55031 | USP47 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.25e-03 | -7.51e-01 | -0.2061 |
55031 | USP47 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.27e-02 | -4.79e-01 | -0.0842 |
55031 | USP47 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.98e-12 | -6.71e-01 | 0.096 |
55031 | USP47 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.83e-02 | -6.95e-01 | 0.0528 |
55031 | USP47 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.32e-07 | -6.27e-01 | 0.0338 |
55031 | USP47 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.14e-21 | -5.54e-01 | 0.0674 |
55031 | USP47 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.64e-04 | -6.33e-01 | 0.0588 |
55031 | USP47 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.31e-06 | -3.74e-01 | 0.294 |
55031 | USP47 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.52e-09 | -4.39e-01 | 0.3859 |
55031 | USP47 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.62e-05 | -6.66e-01 | 0.2585 |
55031 | USP47 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.58e-25 | -6.47e-01 | 0.3005 |
55031 | USP47 | A015-C-203 | Human | Colorectum | FAP | 6.69e-28 | -2.14e-01 | -0.1294 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009719310 | Cervix | CC | intrinsic apoptotic signaling pathway | 85/2311 | 288/18723 | 4.56e-15 | 6.46e-12 | 85 |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
GO:200124210 | Cervix | CC | regulation of intrinsic apoptotic signaling pathway | 52/2311 | 164/18723 | 5.06e-11 | 1.01e-08 | 52 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:200011610 | Cervix | CC | regulation of cysteine-type endopeptidase activity | 61/2311 | 235/18723 | 8.69e-09 | 7.22e-07 | 61 |
GO:004328110 | Cervix | CC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 55/2311 | 209/18723 | 2.77e-08 | 1.95e-06 | 55 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:200123410 | Cervix | CC | negative regulation of apoptotic signaling pathway | 56/2311 | 224/18723 | 1.39e-07 | 6.70e-06 | 56 |
GO:00447725 | Cervix | CC | mitotic cell cycle phase transition | 89/2311 | 424/18723 | 2.70e-07 | 1.12e-05 | 89 |
GO:00513469 | Cervix | CC | negative regulation of hydrolase activity | 81/2311 | 379/18723 | 4.27e-07 | 1.67e-05 | 81 |
GO:00104669 | Cervix | CC | negative regulation of peptidase activity | 60/2311 | 262/18723 | 1.27e-06 | 4.34e-05 | 60 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:00712148 | Cervix | CC | cellular response to abiotic stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:01040048 | Cervix | CC | cellular response to environmental stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:001095110 | Cervix | CC | negative regulation of endopeptidase activity | 56/2311 | 252/18723 | 7.43e-06 | 1.74e-04 | 56 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP47 | SNV | Missense_Mutation | c.1984N>T | p.Asp662Tyr | p.D662Y | Q96K76 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
USP47 | SNV | Missense_Mutation | novel | c.2899A>T | p.Ser967Cys | p.S967C | Q96K76 | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-44-7659-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
USP47 | SNV | Missense_Mutation | c.2515N>T | p.Arg839Trp | p.R839W | Q96K76 | protein_coding | deleterious(0) | benign(0.221) | TCGA-55-1596-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
USP47 | SNV | Missense_Mutation | c.3640N>C | p.Asp1214His | p.D1214H | Q96K76 | protein_coding | deleterious(0.04) | benign(0.3) | TCGA-55-6982-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD | |
USP47 | SNV | Missense_Mutation | c.2195T>A | p.Ile732Lys | p.I732K | Q96K76 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-62-8398-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | CR | |
USP47 | SNV | Missense_Mutation | novel | c.1703G>C | p.Arg568Thr | p.R568T | Q96K76 | protein_coding | deleterious(0.01) | possibly_damaging(0.899) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
USP47 | SNV | Missense_Mutation | c.3907N>T | p.Val1303Phe | p.V1303F | Q96K76 | protein_coding | deleterious(0.01) | benign(0.353) | TCGA-91-6828-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
USP47 | SNV | Missense_Mutation | novel | c.2605N>C | p.Val869Leu | p.V869L | Q96K76 | protein_coding | tolerated_low_confidence(0.36) | possibly_damaging(0.846) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP47 | SNV | Missense_Mutation | rs371170010 | c.4045N>T | p.Arg1349Cys | p.R1349C | Q96K76 | protein_coding | deleterious(0.02) | benign(0.432) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
USP47 | SNV | Missense_Mutation | c.1791N>C | p.Lys597Asn | p.K597N | Q96K76 | protein_coding | tolerated(0.09) | benign(0.066) | TCGA-NJ-A4YI-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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