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Gene: UHRF1BP1L |
Gene summary for UHRF1BP1L |
Gene summary. |
Gene information | Species | Human | Gene symbol | UHRF1BP1L | Gene ID | 23074 |
Gene name | UHRF1 binding protein 1 like | |
Gene Alias | SHIP164 | |
Cytomap | 12q23.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0JNW5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23074 | UHRF1BP1L | LZE4T | Human | Esophagus | ESCC | 1.76e-13 | 2.00e-01 | 0.0811 |
23074 | UHRF1BP1L | LZE7T | Human | Esophagus | ESCC | 2.33e-04 | 2.49e-01 | 0.0667 |
23074 | UHRF1BP1L | LZE8T | Human | Esophagus | ESCC | 3.28e-03 | 8.14e-02 | 0.067 |
23074 | UHRF1BP1L | LZE24T | Human | Esophagus | ESCC | 5.07e-12 | 2.66e-01 | 0.0596 |
23074 | UHRF1BP1L | P2T-E | Human | Esophagus | ESCC | 6.01e-40 | 6.97e-01 | 0.1177 |
23074 | UHRF1BP1L | P4T-E | Human | Esophagus | ESCC | 7.83e-12 | 2.15e-01 | 0.1323 |
23074 | UHRF1BP1L | P5T-E | Human | Esophagus | ESCC | 7.38e-07 | 1.27e-01 | 0.1327 |
23074 | UHRF1BP1L | P8T-E | Human | Esophagus | ESCC | 3.06e-08 | 1.66e-01 | 0.0889 |
23074 | UHRF1BP1L | P9T-E | Human | Esophagus | ESCC | 1.34e-07 | 1.70e-01 | 0.1131 |
23074 | UHRF1BP1L | P10T-E | Human | Esophagus | ESCC | 3.44e-10 | 1.10e-01 | 0.116 |
23074 | UHRF1BP1L | P11T-E | Human | Esophagus | ESCC | 3.49e-10 | 5.10e-01 | 0.1426 |
23074 | UHRF1BP1L | P12T-E | Human | Esophagus | ESCC | 8.52e-14 | 2.91e-01 | 0.1122 |
23074 | UHRF1BP1L | P15T-E | Human | Esophagus | ESCC | 4.98e-16 | 3.25e-01 | 0.1149 |
23074 | UHRF1BP1L | P16T-E | Human | Esophagus | ESCC | 3.24e-11 | 2.70e-01 | 0.1153 |
23074 | UHRF1BP1L | P17T-E | Human | Esophagus | ESCC | 5.45e-03 | 1.06e-01 | 0.1278 |
23074 | UHRF1BP1L | P19T-E | Human | Esophagus | ESCC | 1.51e-02 | 2.94e-01 | 0.1662 |
23074 | UHRF1BP1L | P20T-E | Human | Esophagus | ESCC | 4.81e-12 | 2.45e-01 | 0.1124 |
23074 | UHRF1BP1L | P21T-E | Human | Esophagus | ESCC | 8.99e-12 | 2.27e-01 | 0.1617 |
23074 | UHRF1BP1L | P22T-E | Human | Esophagus | ESCC | 5.00e-07 | 1.82e-01 | 0.1236 |
23074 | UHRF1BP1L | P23T-E | Human | Esophagus | ESCC | 3.56e-11 | 3.36e-01 | 0.108 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UHRF1BP1L | SNV | Missense_Mutation | c.4009C>T | p.Pro1337Ser | p.P1337S | A0JNW5 | protein_coding | tolerated(0.06) | benign(0.209) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UHRF1BP1L | SNV | Missense_Mutation | c.503G>A | p.Arg168His | p.R168H | A0JNW5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
UHRF1BP1L | SNV | Missense_Mutation | c.2798N>A | p.Ser933Tyr | p.S933Y | A0JNW5 | protein_coding | deleterious(0.02) | possibly_damaging(0.906) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UHRF1BP1L | SNV | Missense_Mutation | c.1954N>A | p.Leu652Ile | p.L652I | A0JNW5 | protein_coding | tolerated(0.25) | benign(0.077) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UHRF1BP1L | SNV | Missense_Mutation | novel | c.3257N>A | p.Pro1086His | p.P1086H | A0JNW5 | protein_coding | deleterious(0.03) | benign(0.01) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
UHRF1BP1L | SNV | Missense_Mutation | rs377236620 | c.3266N>A | p.Arg1089His | p.R1089H | A0JNW5 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
UHRF1BP1L | SNV | Missense_Mutation | novel | c.1583N>T | p.Ala528Val | p.A528V | A0JNW5 | protein_coding | deleterious(0.01) | probably_damaging(0.942) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
UHRF1BP1L | SNV | Missense_Mutation | novel | c.3490N>A | p.Leu1164Ile | p.L1164I | A0JNW5 | protein_coding | tolerated(0.41) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UHRF1BP1L | SNV | Missense_Mutation | novel | c.295A>C | p.Ser99Arg | p.S99R | A0JNW5 | protein_coding | deleterious(0.02) | benign(0.062) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
UHRF1BP1L | SNV | Missense_Mutation | novel | c.631A>G | p.Thr211Ala | p.T211A | A0JNW5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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