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Gene: TSPYL2 |
Gene summary for TSPYL2 |
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Gene information | Species | Human | Gene symbol | TSPYL2 | Gene ID | 64061 |
Gene name | TSPY like 2 | |
Gene Alias | CDA1 | |
Cytomap | Xp11.22 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q9H2G4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64061 | TSPYL2 | GSM4909277 | Human | Breast | Precancer | 3.67e-05 | 7.34e-01 | 0.0177 |
64061 | TSPYL2 | GSM4909280 | Human | Breast | Precancer | 1.08e-04 | 5.93e-01 | 0.0305 |
64061 | TSPYL2 | GSM4909296 | Human | Breast | IDC | 5.10e-04 | -1.73e-01 | 0.1524 |
64061 | TSPYL2 | GSM4909311 | Human | Breast | IDC | 1.91e-05 | -1.94e-01 | 0.1534 |
64061 | TSPYL2 | GSM4909312 | Human | Breast | IDC | 7.95e-05 | -2.03e-01 | 0.1552 |
64061 | TSPYL2 | GSM4909319 | Human | Breast | IDC | 1.24e-08 | -1.19e-01 | 0.1563 |
64061 | TSPYL2 | NCCBC14 | Human | Breast | DCIS | 1.81e-05 | -2.19e-01 | 0.2021 |
64061 | TSPYL2 | NCCBC5 | Human | Breast | DCIS | 1.04e-02 | -2.00e-01 | 0.2046 |
64061 | TSPYL2 | P1 | Human | Breast | IDC | 1.86e-04 | -1.14e-01 | 0.1527 |
64061 | TSPYL2 | DCIS2 | Human | Breast | DCIS | 1.51e-40 | 1.66e-01 | 0.0085 |
64061 | TSPYL2 | LZE4T | Human | Esophagus | ESCC | 1.08e-07 | 4.50e-01 | 0.0811 |
64061 | TSPYL2 | LZE7T | Human | Esophagus | ESCC | 2.30e-05 | 4.33e-01 | 0.0667 |
64061 | TSPYL2 | LZE24T | Human | Esophagus | ESCC | 2.73e-23 | 7.75e-01 | 0.0596 |
64061 | TSPYL2 | LZE21T | Human | Esophagus | ESCC | 2.09e-05 | 5.86e-01 | 0.0655 |
64061 | TSPYL2 | LZE6T | Human | Esophagus | ESCC | 4.88e-03 | 2.52e-01 | 0.0845 |
64061 | TSPYL2 | P1T-E | Human | Esophagus | ESCC | 1.46e-08 | 7.37e-01 | 0.0875 |
64061 | TSPYL2 | P2T-E | Human | Esophagus | ESCC | 6.55e-28 | 6.20e-01 | 0.1177 |
64061 | TSPYL2 | P4T-E | Human | Esophagus | ESCC | 1.96e-35 | 9.32e-01 | 0.1323 |
64061 | TSPYL2 | P5T-E | Human | Esophagus | ESCC | 1.74e-11 | 2.89e-01 | 0.1327 |
64061 | TSPYL2 | P8T-E | Human | Esophagus | ESCC | 3.96e-10 | 1.54e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160497 | Breast | Precancer | cell growth | 46/1080 | 482/18723 | 5.63e-04 | 7.16e-03 | 46 |
GO:00015587 | Breast | Precancer | regulation of cell growth | 39/1080 | 414/18723 | 1.81e-03 | 1.78e-02 | 39 |
GO:001604913 | Breast | IDC | cell growth | 56/1434 | 482/18723 | 1.16e-03 | 1.26e-02 | 56 |
GO:000155813 | Breast | IDC | regulation of cell growth | 49/1434 | 414/18723 | 1.55e-03 | 1.55e-02 | 49 |
GO:001604923 | Breast | DCIS | cell growth | 54/1390 | 482/18723 | 1.60e-03 | 1.59e-02 | 54 |
GO:000155822 | Breast | DCIS | regulation of cell growth | 47/1390 | 414/18723 | 2.39e-03 | 2.16e-02 | 47 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00062754 | Esophagus | ESCC | regulation of DNA replication | 73/8552 | 107/18723 | 1.97e-06 | 2.28e-05 | 73 |
GO:00459267 | Esophagus | ESCC | negative regulation of growth | 148/8552 | 249/18723 | 7.88e-06 | 7.73e-05 | 148 |
GO:00303085 | Esophagus | ESCC | negative regulation of cell growth | 108/8552 | 188/18723 | 7.46e-04 | 3.87e-03 | 108 |
GO:001604911 | Liver | Cirrhotic | cell growth | 160/4634 | 482/18723 | 1.50e-05 | 2.07e-04 | 160 |
GO:000155811 | Liver | Cirrhotic | regulation of cell growth | 132/4634 | 414/18723 | 5.53e-04 | 4.36e-03 | 132 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:0045786 | Liver | HCC | negative regulation of cell cycle | 204/7958 | 385/18723 | 1.84e-05 | 1.99e-04 | 204 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSPYL2 | deletion | Frame_Shift_Del | c.378delG | p.Ser127AlafsTer20 | p.S127Afs*20 | Q9H2G4 | protein_coding | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TSPYL2 | deletion | Frame_Shift_Del | novel | c.2074delA | p.Thr692ProfsTer27 | p.T692Pfs*27 | Q9H2G4 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
TSPYL2 | deletion | Frame_Shift_Del | c.243delN | p.Ile84SerfsTer63 | p.I84Sfs*63 | Q9H2G4 | protein_coding | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | |||
TSPYL2 | SNV | Missense_Mutation | rs369549099 | c.1058N>A | p.Arg353His | p.R353H | Q9H2G4 | protein_coding | tolerated(1) | benign(0.003) | TCGA-EL-A3CR-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TSPYL2 | insertion | Frame_Shift_Ins | novel | c.1582_1583insTGAATTGTCTC | p.Asn528MetfsTer100 | p.N528Mfs*100 | Q9H2G4 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
64061 | TSPYL2 | NA | BROMODEOXYURIDINE | 11395479 | ||
64061 | TSPYL2 | NA | RETINOIC ACID | 15823505 | ||
64061 | TSPYL2 | NA | TGFBETA1 | 15823505 | ||
64061 | TSPYL2 | NA | SODIUM BUTYRATE | 12619135 |
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