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Gene: TSHR |
Gene summary for TSHR |
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Gene information | Species | Human | Gene symbol | TSHR | Gene ID | 7253 |
Gene name | thyroid stimulating hormone receptor | |
Gene Alias | CHNG1 | |
Cytomap | 14q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | A0A0A0MTJ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7253 | TSHR | Adj_PTCwithHT_6 | Human | Thyroid | HT | 3.64e-25 | -9.99e-01 | 0.02 |
7253 | TSHR | Adj_PTCwithHT_8 | Human | Thyroid | HT | 5.93e-03 | -4.54e-01 | 0.0267 |
7253 | TSHR | PTCwithHT_1 | Human | Thyroid | HT | 2.53e-07 | -9.04e-01 | 0.0238 |
7253 | TSHR | PTCwithHT_6 | Human | Thyroid | HT | 3.32e-20 | -9.07e-01 | 0.02 |
7253 | TSHR | PTCwithHT_8 | Human | Thyroid | HT | 1.39e-08 | -6.41e-01 | 0.0351 |
7253 | TSHR | PTCwithoutHT_2 | Human | Thyroid | PTC | 7.21e-05 | -4.80e-01 | 0.0419 |
7253 | TSHR | PTCwithoutHT_7 | Human | Thyroid | PTC | 6.98e-03 | -5.77e-01 | 0.0381 |
7253 | TSHR | male-WTA | Human | Thyroid | PTC | 4.03e-60 | 8.32e-02 | 0.1037 |
7253 | TSHR | PTC01 | Human | Thyroid | PTC | 5.07e-18 | 9.11e-01 | 0.1899 |
7253 | TSHR | PTC03 | Human | Thyroid | PTC | 6.20e-03 | 9.62e-01 | 0.1784 |
7253 | TSHR | PTC04 | Human | Thyroid | PTC | 4.90e-07 | 6.80e-01 | 0.1927 |
7253 | TSHR | PTC05 | Human | Thyroid | PTC | 1.92e-13 | 1.41e+00 | 0.2065 |
7253 | TSHR | PTC06 | Human | Thyroid | PTC | 1.67e-41 | 1.72e+00 | 0.2057 |
7253 | TSHR | PTC07 | Human | Thyroid | PTC | 1.16e-53 | 1.65e+00 | 0.2044 |
7253 | TSHR | ATC08 | Human | Thyroid | ATC | 7.40e-19 | -6.06e-01 | 0.0541 |
7253 | TSHR | ATC09 | Human | Thyroid | ATC | 6.12e-12 | -9.82e-01 | 0.2871 |
7253 | TSHR | ATC11 | Human | Thyroid | ATC | 4.89e-02 | -1.01e+00 | 0.3386 |
7253 | TSHR | ATC12 | Human | Thyroid | ATC | 1.89e-29 | -1.01e+00 | 0.34 |
7253 | TSHR | ATC13 | Human | Thyroid | ATC | 2.36e-29 | -1.01e+00 | 0.34 |
7253 | TSHR | ATC1 | Human | Thyroid | ATC | 2.96e-09 | -9.94e-01 | 0.2878 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190165324 | Thyroid | HT | cellular response to peptide | 46/1272 | 359/18723 | 2.46e-05 | 5.48e-04 | 46 |
GO:004343427 | Thyroid | HT | response to peptide hormone | 49/1272 | 414/18723 | 1.05e-04 | 1.75e-03 | 49 |
GO:19908455 | Thyroid | HT | adaptive thermogenesis | 22/1272 | 157/18723 | 9.54e-04 | 9.83e-03 | 22 |
GO:00016595 | Thyroid | HT | temperature homeostasis | 23/1272 | 174/18723 | 1.64e-03 | 1.50e-02 | 23 |
GO:01061067 | Thyroid | HT | cold-induced thermogenesis | 20/1272 | 144/18723 | 1.77e-03 | 1.59e-02 | 20 |
GO:01201617 | Thyroid | HT | regulation of cold-induced thermogenesis | 20/1272 | 144/18723 | 1.77e-03 | 1.59e-02 | 20 |
GO:007137519 | Thyroid | HT | cellular response to peptide hormone stimulus | 33/1272 | 290/18723 | 2.53e-03 | 2.12e-02 | 33 |
GO:1901653111 | Thyroid | PTC | cellular response to peptide | 169/5968 | 359/18723 | 9.81e-10 | 2.89e-08 | 169 |
GO:0043434113 | Thyroid | PTC | response to peptide hormone | 188/5968 | 414/18723 | 4.13e-09 | 1.09e-07 | 188 |
GO:0071375110 | Thyroid | PTC | cellular response to peptide hormone stimulus | 136/5968 | 290/18723 | 5.49e-08 | 1.17e-06 | 136 |
GO:000975519 | Thyroid | PTC | hormone-mediated signaling pathway | 80/5968 | 190/18723 | 1.84e-03 | 9.91e-03 | 80 |
GO:010610613 | Thyroid | PTC | cold-induced thermogenesis | 61/5968 | 144/18723 | 5.08e-03 | 2.35e-02 | 61 |
GO:012016113 | Thyroid | PTC | regulation of cold-induced thermogenesis | 61/5968 | 144/18723 | 5.08e-03 | 2.35e-02 | 61 |
GO:199084513 | Thyroid | PTC | adaptive thermogenesis | 64/5968 | 157/18723 | 1.14e-02 | 4.50e-02 | 64 |
GO:190165325 | Thyroid | ATC | cellular response to peptide | 173/6293 | 359/18723 | 5.87e-09 | 1.28e-07 | 173 |
GO:004343428 | Thyroid | ATC | response to peptide hormone | 192/6293 | 414/18723 | 3.63e-08 | 6.70e-07 | 192 |
GO:007137524 | Thyroid | ATC | cellular response to peptide hormone stimulus | 138/6293 | 290/18723 | 4.90e-07 | 7.05e-06 | 138 |
GO:010610621 | Thyroid | ATC | cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:012016121 | Thyroid | ATC | regulation of cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:199084521 | Thyroid | ATC | adaptive thermogenesis | 71/6293 | 157/18723 | 1.59e-03 | 7.99e-03 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSHR | SNV | Missense_Mutation | c.640N>G | p.Thr214Ala | p.T214A | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TSHR | SNV | Missense_Mutation | rs369995834 | c.1532N>T | p.Thr511Met | p.T511M | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8380-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | polyplatillen | PD | |
TSHR | SNV | Missense_Mutation | c.788T>C | p.Leu263Pro | p.L263P | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | ||
TSHR | SNV | Missense_Mutation | c.2278N>G | p.Met760Val | p.M760V | protein_coding | tolerated_low_confidence(0.1) | benign(0) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TSHR | SNV | Missense_Mutation | rs139352934 | c.1826N>A | p.Arg609Gln | p.R609Q | protein_coding | tolerated(0.29) | possibly_damaging(0.776) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TSHR | SNV | Missense_Mutation | rs757875222 | c.1723N>A | p.Glu575Lys | p.E575K | protein_coding | deleterious(0.04) | benign(0.035) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | |
TSHR | SNV | Missense_Mutation | novel | c.2018C>A | p.Ala673Asp | p.A673D | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IN-AB1V-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TSHR | SNV | Missense_Mutation | novel | c.1366N>A | p.Leu456Met | p.L456M | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TSHR | SNV | Missense_Mutation | rs746685925 | c.751N>A | p.Glu251Lys | p.E251K | protein_coding | tolerated(1) | benign(0.223) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
TSHR | SNV | Missense_Mutation | c.88G>A | p.Glu30Lys | p.E30K | protein_coding | tolerated(0.2) | possibly_damaging(0.801) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | SIBUTRAMINE HYDROCHLORIDE | SIBUTRAMINE HYDROCHLORIDE | ||
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | (S)-FLUOXETINE | CHEMBL1169388 | ||
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | BERGAMOTTIN | BERGAMOTTIN | ||
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | THYROTROPIN ALFA | |||
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | DECANOIC ACID | DECANOIC ACID | ||
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | (S)-VERAPAMIL | (S)-VERAPAMIL | ||
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | GNF-PF-2893 | CHEMBL312032 | ||
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | SB-222200 | SB-222200 | ||
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | DEXPROPRANOLOL | DEXPROPRANOLOL | ||
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | CLOTRIMAZOLE | CLOTRIMAZOLE |
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