![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TIMELESS |
Gene summary for TIMELESS |
![]() |
Gene information | Species | Human | Gene symbol | TIMELESS | Gene ID | 8914 |
Gene name | timeless circadian regulator | |
Gene Alias | TIM | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q9UNS1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8914 | TIMELESS | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 3.61e-01 | 0.082 |
8914 | TIMELESS | LZE7T | Human | Esophagus | ESCC | 1.62e-04 | 2.47e-01 | 0.0667 |
8914 | TIMELESS | LZE22T | Human | Esophagus | ESCC | 1.48e-05 | 3.61e-01 | 0.068 |
8914 | TIMELESS | LZE24T | Human | Esophagus | ESCC | 4.35e-08 | 2.17e-01 | 0.0596 |
8914 | TIMELESS | P1T-E | Human | Esophagus | ESCC | 1.09e-04 | 3.46e-01 | 0.0875 |
8914 | TIMELESS | P2T-E | Human | Esophagus | ESCC | 3.95e-30 | 6.64e-01 | 0.1177 |
8914 | TIMELESS | P4T-E | Human | Esophagus | ESCC | 1.49e-09 | 2.71e-01 | 0.1323 |
8914 | TIMELESS | P5T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.08e-01 | 0.1327 |
8914 | TIMELESS | P8T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.51e-01 | 0.0889 |
8914 | TIMELESS | P9T-E | Human | Esophagus | ESCC | 2.30e-02 | 1.06e-01 | 0.1131 |
8914 | TIMELESS | P10T-E | Human | Esophagus | ESCC | 9.20e-06 | 2.10e-01 | 0.116 |
8914 | TIMELESS | P11T-E | Human | Esophagus | ESCC | 4.74e-03 | 1.45e-01 | 0.1426 |
8914 | TIMELESS | P12T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.39e-01 | 0.1122 |
8914 | TIMELESS | P15T-E | Human | Esophagus | ESCC | 7.99e-08 | 2.18e-01 | 0.1149 |
8914 | TIMELESS | P16T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.53e-01 | 0.1153 |
8914 | TIMELESS | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 2.04e-01 | 0.1278 |
8914 | TIMELESS | P19T-E | Human | Esophagus | ESCC | 4.64e-06 | 4.32e-01 | 0.1662 |
8914 | TIMELESS | P20T-E | Human | Esophagus | ESCC | 2.18e-03 | 1.32e-01 | 0.1124 |
8914 | TIMELESS | P21T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.79e-01 | 0.1617 |
8914 | TIMELESS | P22T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.92e-01 | 0.1236 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:005105417 | Esophagus | ESCC | positive regulation of DNA metabolic process | 139/8552 | 201/18723 | 1.20e-11 | 4.33e-10 | 139 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:00315705 | Esophagus | ESCC | DNA integrity checkpoint | 83/8552 | 123/18723 | 8.17e-07 | 1.06e-05 | 83 |
GO:19019883 | Esophagus | ESCC | negative regulation of cell cycle phase transition | 151/8552 | 249/18723 | 1.28e-06 | 1.57e-05 | 151 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
GO:00062754 | Esophagus | ESCC | regulation of DNA replication | 73/8552 | 107/18723 | 1.97e-06 | 2.28e-05 | 73 |
GO:20010228 | Esophagus | ESCC | positive regulation of response to DNA damage stimulus | 69/8552 | 105/18723 | 2.66e-05 | 2.22e-04 | 69 |
GO:00062826 | Esophagus | ESCC | regulation of DNA repair | 82/8552 | 130/18723 | 4.65e-05 | 3.66e-04 | 82 |
GO:00457395 | Esophagus | ESCC | positive regulation of DNA repair | 49/8552 | 73/18723 | 1.74e-04 | 1.14e-03 | 49 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:004851118 | Esophagus | ESCC | rhythmic process | 164/8552 | 298/18723 | 6.80e-04 | 3.57e-03 | 164 |
GO:000762319 | Esophagus | ESCC | circadian rhythm | 119/8552 | 210/18723 | 8.47e-04 | 4.36e-03 | 119 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIMELESS | SNV | Missense_Mutation | novel | c.61N>A | p.Glu21Lys | p.E21K | Q9UNS1 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TIMELESS | SNV | Missense_Mutation | novel | c.77N>T | p.His26Leu | p.H26L | Q9UNS1 | protein_coding | tolerated(0.09) | possibly_damaging(0.843) | TCGA-CV-5439-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
TIMELESS | SNV | Missense_Mutation | novel | c.1354G>A | p.Glu452Lys | p.E452K | Q9UNS1 | protein_coding | tolerated(0.07) | benign(0.018) | TCGA-P3-A6T5-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TIMELESS | SNV | Missense_Mutation | novel | c.2911N>G | p.Leu971Val | p.L971V | Q9UNS1 | protein_coding | tolerated(0.59) | benign(0.062) | TCGA-WA-A7H4-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TIMELESS | SNV | Missense_Mutation | rs776587905 | c.1988N>A | p.Arg663His | p.R663H | Q9UNS1 | protein_coding | tolerated(0.09) | benign(0.058) | TCGA-EJ-5505-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
TIMELESS | SNV | Missense_Mutation | c.3374N>G | p.His1125Arg | p.H1125R | Q9UNS1 | protein_coding | tolerated_low_confidence(0.52) | benign(0.042) | TCGA-EJ-5516-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
TIMELESS | SNV | Missense_Mutation | rs758367557 | c.2578N>T | p.Arg860Cys | p.R860C | Q9UNS1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD |
TIMELESS | SNV | Missense_Mutation | novel | c.3098N>T | p.Arg1033Leu | p.R1033L | Q9UNS1 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-HC-7081-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
TIMELESS | SNV | Missense_Mutation | novel | c.1373N>T | p.Asp458Val | p.D458V | Q9UNS1 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-J4-A67Q-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD |
TIMELESS | SNV | Missense_Mutation | c.205N>A | p.Leu69Ile | p.L69I | Q9UNS1 | protein_coding | tolerated(0.35) | benign(0.129) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |