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Gene: THSD7A |
Gene summary for THSD7A |
Gene summary. |
Gene information | Species | Human | Gene symbol | THSD7A | Gene ID | 221981 |
Gene name | thrombospondin type 1 domain containing 7A | |
Gene Alias | THSD7A | |
Cytomap | 7p21.3 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q9UPZ6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221981 | THSD7A | AEH-subject1 | Human | Endometrium | AEH | 1.23e-03 | 1.95e-01 | -0.3059 |
221981 | THSD7A | AEH-subject2 | Human | Endometrium | AEH | 5.19e-09 | 3.90e-01 | -0.2525 |
221981 | THSD7A | AEH-subject3 | Human | Endometrium | AEH | 9.25e-23 | 5.88e-01 | -0.2576 |
221981 | THSD7A | AEH-subject4 | Human | Endometrium | AEH | 2.18e-09 | 4.48e-01 | -0.2657 |
221981 | THSD7A | AEH-subject5 | Human | Endometrium | AEH | 1.13e-25 | 6.52e-01 | -0.2953 |
221981 | THSD7A | EEC-subject1 | Human | Endometrium | EEC | 1.54e-10 | 4.00e-01 | -0.2682 |
221981 | THSD7A | EEC-subject2 | Human | Endometrium | EEC | 9.37e-10 | 3.81e-01 | -0.2607 |
221981 | THSD7A | EEC-subject4 | Human | Endometrium | EEC | 1.11e-05 | 3.14e-01 | -0.2571 |
221981 | THSD7A | GSM5276935 | Human | Endometrium | EEC | 4.72e-03 | 1.57e-01 | -0.123 |
221981 | THSD7A | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.97e-07 | 3.23e-01 | -0.1934 |
221981 | THSD7A | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 5.88e-14 | 7.73e-01 | -0.2116 |
221981 | THSD7A | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.37e-03 | 5.43e-01 | -0.2107 |
221981 | THSD7A | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.17e-06 | 5.07e-01 | -0.2119 |
221981 | THSD7A | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.59e-09 | 5.35e-01 | -0.0166 |
221981 | THSD7A | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.29e-14 | 5.97e-01 | -0.0132 |
221981 | THSD7A | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.37e-11 | 5.04e-01 | -0.013 |
221981 | THSD7A | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 8.87e-08 | 4.70e-01 | -0.0121 |
221981 | THSD7A | HTA12-15-2 | Human | Pancreas | PDAC | 4.88e-04 | 5.83e-01 | 0.2315 |
221981 | THSD7A | HTA12-23-1 | Human | Pancreas | PDAC | 1.73e-13 | 1.14e+00 | 0.3405 |
221981 | THSD7A | HTA12-25-1 | Human | Pancreas | PDAC | 4.35e-08 | 7.27e-01 | 0.313 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315329 | Endometrium | AEH | actin cytoskeleton reorganization | 32/2100 | 107/18723 | 1.24e-07 | 5.80e-06 | 32 |
GO:003153214 | Endometrium | EEC | actin cytoskeleton reorganization | 33/2168 | 107/18723 | 7.46e-08 | 3.89e-06 | 33 |
GO:00315327 | Lung | IAC | actin cytoskeleton reorganization | 35/2061 | 107/18723 | 1.44e-09 | 2.38e-07 | 35 |
GO:003153213 | Lung | AIS | actin cytoskeleton reorganization | 31/1849 | 107/18723 | 2.36e-08 | 3.12e-06 | 31 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THSD7A | SNV | Missense_Mutation | c.860N>A | p.Arg287His | p.R287H | Q9UPZ6 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THSD7A | SNV | Missense_Mutation | novel | c.1552N>C | p.Trp518Arg | p.W518R | Q9UPZ6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THSD7A | SNV | Missense_Mutation | novel | c.4913N>T | p.Arg1638Ile | p.R1638I | Q9UPZ6 | protein_coding | deleterious(0.04) | benign(0.046) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THSD7A | SNV | Missense_Mutation | novel | c.3314N>T | p.Ser1105Ile | p.S1105I | Q9UPZ6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THSD7A | SNV | Missense_Mutation | rs747391850 | c.806N>A | p.Arg269Gln | p.R269Q | Q9UPZ6 | protein_coding | tolerated(0.07) | possibly_damaging(0.86) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THSD7A | SNV | Missense_Mutation | c.3673A>G | p.Asn1225Asp | p.N1225D | Q9UPZ6 | protein_coding | deleterious(0.03) | possibly_damaging(0.772) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
THSD7A | SNV | Missense_Mutation | novel | c.2887N>A | p.Ala963Thr | p.A963T | Q9UPZ6 | protein_coding | tolerated(0.09) | benign(0.298) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THSD7A | SNV | Missense_Mutation | novel | c.248N>T | p.Ala83Val | p.A83V | Q9UPZ6 | protein_coding | tolerated(0.07) | benign(0.077) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THSD7A | SNV | Missense_Mutation | rs866026861 | c.4265C>T | p.Ser1422Phe | p.S1422F | Q9UPZ6 | protein_coding | deleterious(0.02) | possibly_damaging(0.601) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
THSD7A | SNV | Missense_Mutation | novel | c.2995C>T | p.Arg999Cys | p.R999C | Q9UPZ6 | protein_coding | deleterious(0.01) | possibly_damaging(0.777) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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