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Gene: TCF4 |
Gene summary for TCF4 |
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Gene information | Species | Human | Gene symbol | TCF4 | Gene ID | 6925 |
Gene name | transcription factor 4 | |
Gene Alias | CDG2T | |
Cytomap | 18q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KVA4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6925 | TCF4 | CA_HPV_1 | Human | Cervix | CC | 1.03e-14 | 5.39e-01 | 0.0264 |
6925 | TCF4 | CA_HPV_3 | Human | Cervix | CC | 3.25e-02 | 1.77e-02 | 0.0414 |
6925 | TCF4 | N_HPV_1 | Human | Cervix | N_HPV | 1.96e-02 | -2.47e-01 | 0.0079 |
6925 | TCF4 | CCI_3 | Human | Cervix | CC | 2.50e-04 | 9.53e-01 | 0.516 |
6925 | TCF4 | CCII_1 | Human | Cervix | CC | 3.14e-02 | -3.11e-01 | 0.3249 |
6925 | TCF4 | Tumor | Human | Cervix | CC | 4.44e-02 | -2.74e-01 | 0.1241 |
6925 | TCF4 | sample1 | Human | Cervix | CC | 3.44e-04 | -3.55e-01 | 0.0959 |
6925 | TCF4 | sample3 | Human | Cervix | CC | 1.62e-04 | -2.11e-01 | 0.1387 |
6925 | TCF4 | H2 | Human | Cervix | HSIL_HPV | 1.41e-04 | -2.57e-01 | 0.0632 |
6925 | TCF4 | T1 | Human | Cervix | CC | 1.12e-04 | -2.89e-01 | 0.0918 |
6925 | TCF4 | T3 | Human | Cervix | CC | 3.97e-03 | -2.16e-01 | 0.1389 |
6925 | TCF4 | AEH-subject1 | Human | Endometrium | AEH | 3.69e-04 | -2.95e-01 | -0.3059 |
6925 | TCF4 | AEH-subject2 | Human | Endometrium | AEH | 1.22e-06 | -3.37e-01 | -0.2525 |
6925 | TCF4 | AEH-subject3 | Human | Endometrium | AEH | 9.35e-04 | -2.47e-01 | -0.2576 |
6925 | TCF4 | AEH-subject5 | Human | Endometrium | AEH | 5.71e-05 | -3.28e-01 | -0.2953 |
6925 | TCF4 | EEC-subject2 | Human | Endometrium | EEC | 2.05e-09 | -4.71e-01 | -0.2607 |
6925 | TCF4 | EEC-subject3 | Human | Endometrium | EEC | 5.46e-23 | -4.28e-01 | -0.2525 |
6925 | TCF4 | GSM5276934 | Human | Endometrium | EEC | 2.45e-19 | -5.89e-01 | -0.0913 |
6925 | TCF4 | GSM5276935 | Human | Endometrium | EEC | 2.97e-44 | -7.63e-01 | -0.123 |
6925 | TCF4 | GSM5276937 | Human | Endometrium | EEC | 7.68e-17 | -5.83e-01 | -0.0897 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045664 | Prostate | BPH | regulation of neuron differentiation | 46/3107 | 196/18723 | 7.95e-03 | 3.47e-02 | 46 |
GO:00456641 | Prostate | Tumor | regulation of neuron differentiation | 52/3246 | 196/18723 | 7.90e-04 | 5.38e-03 | 52 |
GO:00718241 | Skin | cSCC | protein-DNA complex subunit organization | 87/4864 | 241/18723 | 3.09e-04 | 2.47e-03 | 87 |
GO:00718242 | Thyroid | ATC | protein-DNA complex subunit organization | 103/6293 | 241/18723 | 1.84e-03 | 9.03e-03 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCF4 | SNV | Missense_Mutation | c.1909N>C | p.Asp637His | p.D637H | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | ||
TCF4 | SNV | Missense_Mutation | novel | c.1337A>G | p.Asn446Ser | p.N446S | protein_coding | tolerated(0.6) | probably_damaging(0.995) | TCGA-77-A5GH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TCF4 | SNV | Missense_Mutation | rs755332116 | c.2296G>A | p.Ala766Thr | p.A766T | protein_coding | tolerated(0.44) | benign(0.019) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TCF4 | SNV | Missense_Mutation | novel | c.715G>A | p.Gly239Arg | p.G239R | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-NK-A5CT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TCF4 | deletion | Frame_Shift_Del | novel | c.1776_1777delNN | p.Gln593GlyfsTer21 | p.Q593Gfs*21 | protein_coding | TCGA-99-8032-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
TCF4 | deletion | Frame_Shift_Del | novel | c.2235delN | p.Lys746ArgfsTer39 | p.K746Rfs*39 | protein_coding | TCGA-56-A5DS-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TCF4 | SNV | Missense_Mutation | novel | c.705N>T | p.Met235Ile | p.M235I | protein_coding | tolerated(0.51) | benign(0.003) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
TCF4 | SNV | Missense_Mutation | novel | c.2106G>C | p.Lys702Asn | p.K702N | protein_coding | tolerated(0.28) | probably_damaging(0.999) | TCGA-CQ-6220-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TCF4 | SNV | Missense_Mutation | novel | c.1261N>A | p.Gln421Lys | p.Q421K | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-CR-7386-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | PD | |
TCF4 | SNV | Missense_Mutation | c.1790N>A | p.Arg597Lys | p.R597K | protein_coding | tolerated(0.15) | possibly_damaging(0.597) | TCGA-EJ-7115-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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