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Gene: SULF2 |
Gene summary for SULF2 |
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Gene information | Species | Human | Gene symbol | SULF2 | Gene ID | 55959 |
Gene name | sulfatase 2 | |
Gene Alias | HSULF-2 | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q8IWU5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55959 | SULF2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.79e-10 | -5.02e-01 | 0.0155 |
55959 | SULF2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.22e-06 | -4.10e-01 | 0.096 |
55959 | SULF2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.83e-02 | -4.27e-01 | 0.0338 |
55959 | SULF2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.17e-04 | -3.52e-01 | 0.0674 |
55959 | SULF2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.81e-08 | -3.39e-01 | 0.294 |
55959 | SULF2 | F007 | Human | Colorectum | FAP | 3.62e-06 | -4.72e-01 | 0.1176 |
55959 | SULF2 | A002-C-010 | Human | Colorectum | FAP | 1.35e-19 | -4.65e-01 | 0.242 |
55959 | SULF2 | A001-C-207 | Human | Colorectum | FAP | 5.79e-14 | -5.44e-01 | 0.1278 |
55959 | SULF2 | A015-C-203 | Human | Colorectum | FAP | 2.96e-26 | -5.25e-01 | -0.1294 |
55959 | SULF2 | A015-C-204 | Human | Colorectum | FAP | 1.02e-08 | -4.27e-01 | -0.0228 |
55959 | SULF2 | A014-C-040 | Human | Colorectum | FAP | 7.68e-05 | -5.69e-01 | -0.1184 |
55959 | SULF2 | A002-C-201 | Human | Colorectum | FAP | 6.40e-15 | -4.68e-01 | 0.0324 |
55959 | SULF2 | A002-C-203 | Human | Colorectum | FAP | 9.02e-17 | -4.98e-01 | 0.2786 |
55959 | SULF2 | A001-C-119 | Human | Colorectum | FAP | 1.90e-06 | -4.34e-01 | -0.1557 |
55959 | SULF2 | A001-C-108 | Human | Colorectum | FAP | 4.46e-21 | -5.13e-01 | -0.0272 |
55959 | SULF2 | A002-C-021 | Human | Colorectum | FAP | 1.99e-02 | -3.05e-01 | 0.1171 |
55959 | SULF2 | A002-C-205 | Human | Colorectum | FAP | 1.46e-21 | -5.58e-01 | -0.1236 |
55959 | SULF2 | A001-C-104 | Human | Colorectum | FAP | 2.24e-10 | -4.45e-01 | 0.0184 |
55959 | SULF2 | A015-C-005 | Human | Colorectum | FAP | 2.01e-11 | -5.06e-01 | -0.0336 |
55959 | SULF2 | A015-C-006 | Human | Colorectum | FAP | 1.98e-09 | -3.21e-01 | -0.0994 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0061008 | Colorectum | AD | hepaticobiliary system development | 55/3918 | 150/18723 | 6.34e-06 | 1.59e-04 | 55 |
GO:0001889 | Colorectum | AD | liver development | 54/3918 | 147/18723 | 7.20e-06 | 1.77e-04 | 54 |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0097421 | Colorectum | AD | liver regeneration | 18/3918 | 35/18723 | 6.33e-05 | 1.05e-03 | 18 |
GO:0022612 | Colorectum | AD | gland morphogenesis | 42/3918 | 118/18723 | 1.62e-04 | 2.23e-03 | 42 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:0030177 | Colorectum | AD | positive regulation of Wnt signaling pathway | 45/3918 | 140/18723 | 1.23e-03 | 1.09e-02 | 45 |
GO:0003014 | Colorectum | AD | renal system process | 35/3918 | 110/18723 | 4.85e-03 | 3.27e-02 | 35 |
GO:0031100 | Colorectum | AD | animal organ regeneration | 26/3918 | 76/18723 | 4.94e-03 | 3.32e-02 | 26 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00301112 | Colorectum | MSS | regulation of Wnt signaling pathway | 98/3467 | 328/18723 | 3.37e-07 | 1.36e-05 | 98 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
GO:00610082 | Colorectum | MSS | hepaticobiliary system development | 51/3467 | 150/18723 | 4.33e-06 | 1.23e-04 | 51 |
GO:00018892 | Colorectum | MSS | liver development | 50/3467 | 147/18723 | 5.28e-06 | 1.44e-04 | 50 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SULF2 | SNV | Missense_Mutation | c.1580N>G | p.Tyr527Cys | p.Y527C | Q8IWU5 | protein_coding | tolerated(0.06) | possibly_damaging(0.657) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SULF2 | SNV | Missense_Mutation | novel | c.916N>A | p.Glu306Lys | p.E306K | Q8IWU5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
SULF2 | SNV | Missense_Mutation | c.641N>T | p.Arg214Met | p.R214M | Q8IWU5 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
SULF2 | SNV | Missense_Mutation | c.1346N>T | p.Ala449Val | p.A449V | Q8IWU5 | protein_coding | deleterious(0.02) | possibly_damaging(0.79) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
SULF2 | SNV | Missense_Mutation | novel | c.1118N>T | p.Ala373Val | p.A373V | Q8IWU5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SULF2 | deletion | Frame_Shift_Del | novel | c.2473delN | p.Arg825GlyfsTer29 | p.R825Gfs*29 | Q8IWU5 | protein_coding | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SULF2 | insertion | Frame_Shift_Ins | novel | c.1563_1564insA | p.Leu522ThrfsTer34 | p.L522Tfs*34 | Q8IWU5 | protein_coding | TCGA-CG-5717-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
SULF2 | SNV | Missense_Mutation | c.2431A>T | p.Met811Leu | p.M811L | Q8IWU5 | protein_coding | tolerated(0.08) | possibly_damaging(0.869) | TCGA-EM-A22O-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SULF2 | insertion | Frame_Shift_Ins | novel | c.1918_1919insTAAAGATAAAAAT | p.Asn640IlefsTer8 | p.N640Ifs*8 | Q8IWU5 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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