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Gene: SPAG1 |
Gene summary for SPAG1 |
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Gene information | Species | Human | Gene symbol | SPAG1 | Gene ID | 6674 |
Gene name | sperm associated antigen 1 | |
Gene Alias | CILD28 | |
Cytomap | 8q22.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q07617 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6674 | SPAG1 | P2T-E | Human | Esophagus | ESCC | 1.29e-06 | 1.25e-01 | 0.1177 |
6674 | SPAG1 | P8T-E | Human | Esophagus | ESCC | 1.14e-13 | 2.64e-01 | 0.0889 |
6674 | SPAG1 | P16T-E | Human | Esophagus | ESCC | 1.05e-05 | 1.43e-01 | 0.1153 |
6674 | SPAG1 | P22T-E | Human | Esophagus | ESCC | 6.81e-03 | 6.21e-02 | 0.1236 |
6674 | SPAG1 | P23T-E | Human | Esophagus | ESCC | 1.50e-13 | 4.36e-01 | 0.108 |
6674 | SPAG1 | P26T-E | Human | Esophagus | ESCC | 1.76e-06 | 1.05e-01 | 0.1276 |
6674 | SPAG1 | P27T-E | Human | Esophagus | ESCC | 6.28e-10 | 5.25e-02 | 0.1055 |
6674 | SPAG1 | P28T-E | Human | Esophagus | ESCC | 5.86e-04 | 4.82e-02 | 0.1149 |
6674 | SPAG1 | P32T-E | Human | Esophagus | ESCC | 1.60e-07 | 8.75e-02 | 0.1666 |
6674 | SPAG1 | P37T-E | Human | Esophagus | ESCC | 4.08e-04 | 7.65e-02 | 0.1371 |
6674 | SPAG1 | P39T-E | Human | Esophagus | ESCC | 2.00e-11 | 2.60e-01 | 0.0894 |
6674 | SPAG1 | P52T-E | Human | Esophagus | ESCC | 1.03e-04 | 1.48e-02 | 0.1555 |
6674 | SPAG1 | P57T-E | Human | Esophagus | ESCC | 4.40e-05 | 1.40e-01 | 0.0926 |
6674 | SPAG1 | P62T-E | Human | Esophagus | ESCC | 1.38e-02 | 1.01e-01 | 0.1302 |
6674 | SPAG1 | P74T-E | Human | Esophagus | ESCC | 3.47e-07 | 3.08e-01 | 0.1479 |
6674 | SPAG1 | P75T-E | Human | Esophagus | ESCC | 8.64e-19 | 4.46e-01 | 0.1125 |
6674 | SPAG1 | P76T-E | Human | Esophagus | ESCC | 2.82e-05 | 1.31e-01 | 0.1207 |
6674 | SPAG1 | P82T-E | Human | Esophagus | ESCC | 7.32e-16 | 8.65e-01 | 0.1072 |
6674 | SPAG1 | P83T-E | Human | Esophagus | ESCC | 2.38e-03 | 8.47e-02 | 0.1738 |
6674 | SPAG1 | P127T-E | Human | Esophagus | ESCC | 1.14e-10 | 2.45e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
GO:00602711 | Lung | MIAC | cilium assembly | 37/967 | 337/18723 | 1.29e-05 | 9.85e-04 | 37 |
GO:00447821 | Lung | MIAC | cilium organization | 38/967 | 368/18723 | 3.93e-05 | 2.08e-03 | 38 |
GO:00991113 | Oral cavity | OSCC | microtubule-based transport | 96/7305 | 190/18723 | 7.92e-04 | 4.27e-03 | 96 |
GO:00991115 | Thyroid | PTC | microtubule-based transport | 88/5968 | 190/18723 | 2.08e-05 | 2.08e-04 | 88 |
GO:009911112 | Thyroid | ATC | microtubule-based transport | 91/6293 | 190/18723 | 2.97e-05 | 2.48e-04 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPAG1 | SNV | Missense_Mutation | novel | c.193C>A | p.Leu65Ile | p.L65I | Q07617 | protein_coding | tolerated(0.64) | benign(0.067) | TCGA-SW-A7EB-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD |
SPAG1 | SNV | Missense_Mutation | novel | c.1037N>G | p.Asn346Ser | p.N346S | Q07617 | protein_coding | tolerated(0.07) | benign(0.077) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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