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Gene: SORBS1 |
Gene summary for SORBS1 |
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Gene information | Species | Human | Gene symbol | SORBS1 | Gene ID | 10580 |
Gene name | sorbin and SH3 domain containing 1 | |
Gene Alias | CAP | |
Cytomap | 10q24.1 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q9BX66 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10580 | SORBS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.37e-03 | -3.21e-01 | 0.0155 |
10580 | SORBS1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.51e-03 | 3.61e-01 | 0.096 |
10580 | SORBS1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.23e-20 | 1.24e+00 | 0.3859 |
10580 | SORBS1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.34e-10 | 8.81e-01 | 0.2585 |
10580 | SORBS1 | A001-C-207 | Human | Colorectum | FAP | 3.94e-02 | -2.92e-01 | 0.1278 |
10580 | SORBS1 | A015-C-203 | Human | Colorectum | FAP | 3.26e-08 | -2.33e-02 | -0.1294 |
10580 | SORBS1 | A002-C-201 | Human | Colorectum | FAP | 1.40e-06 | -3.52e-01 | 0.0324 |
10580 | SORBS1 | A002-C-203 | Human | Colorectum | FAP | 2.17e-09 | -3.64e-01 | 0.2786 |
10580 | SORBS1 | A001-C-108 | Human | Colorectum | FAP | 8.19e-08 | -2.84e-01 | -0.0272 |
10580 | SORBS1 | A002-C-205 | Human | Colorectum | FAP | 2.81e-08 | -2.49e-01 | -0.1236 |
10580 | SORBS1 | A015-C-006 | Human | Colorectum | FAP | 1.46e-07 | -4.19e-01 | -0.0994 |
10580 | SORBS1 | A015-C-106 | Human | Colorectum | FAP | 4.37e-03 | -1.48e-01 | -0.0511 |
10580 | SORBS1 | A002-C-114 | Human | Colorectum | FAP | 4.22e-08 | -3.78e-01 | -0.1561 |
10580 | SORBS1 | A015-C-104 | Human | Colorectum | FAP | 1.91e-12 | -2.35e-01 | -0.1899 |
10580 | SORBS1 | A001-C-014 | Human | Colorectum | FAP | 2.35e-05 | -2.34e-01 | 0.0135 |
10580 | SORBS1 | A002-C-016 | Human | Colorectum | FAP | 2.40e-11 | -2.83e-01 | 0.0521 |
10580 | SORBS1 | A015-C-002 | Human | Colorectum | FAP | 2.11e-04 | -3.50e-01 | -0.0763 |
10580 | SORBS1 | A001-C-203 | Human | Colorectum | FAP | 3.27e-02 | 2.59e-02 | -0.0481 |
10580 | SORBS1 | A002-C-116 | Human | Colorectum | FAP | 3.83e-15 | -2.54e-01 | -0.0452 |
10580 | SORBS1 | A014-C-008 | Human | Colorectum | FAP | 7.90e-03 | -1.60e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
GO:1903076 | Colorectum | AD | regulation of protein localization to plasma membrane | 48/3918 | 104/18723 | 7.17e-09 | 4.36e-07 | 48 |
GO:1904375 | Colorectum | AD | regulation of protein localization to cell periphery | 54/3918 | 125/18723 | 1.52e-08 | 9.00e-07 | 54 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:1905477 | Colorectum | AD | positive regulation of protein localization to membrane | 46/3918 | 106/18723 | 1.47e-07 | 6.64e-06 | 46 |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:0150115 | Colorectum | AD | cell-substrate junction organization | 44/3918 | 101/18723 | 2.38e-07 | 9.81e-06 | 44 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0007044 | Colorectum | AD | cell-substrate junction assembly | 41/3918 | 95/18723 | 8.20e-07 | 2.85e-05 | 41 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0061572 | Colorectum | AD | actin filament bundle organization | 60/3918 | 161/18723 | 1.33e-06 | 4.23e-05 | 60 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa04910 | Colorectum | MSS | Insulin signaling pathway | 43/1875 | 137/8465 | 7.37e-03 | 2.84e-02 | 1.74e-02 | 43 |
hsa045205 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa049101 | Colorectum | MSS | Insulin signaling pathway | 43/1875 | 137/8465 | 7.37e-03 | 2.84e-02 | 1.74e-02 | 43 |
hsa045208 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa049102 | Colorectum | FAP | Insulin signaling pathway | 36/1404 | 137/8465 | 2.51e-03 | 1.18e-02 | 7.18e-03 | 36 |
hsa045209 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa049103 | Colorectum | FAP | Insulin signaling pathway | 36/1404 | 137/8465 | 2.51e-03 | 1.18e-02 | 7.18e-03 | 36 |
hsa0452010 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452011 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452025 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa04520111 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa0452026 | Endometrium | EEC | Adherens junction | 36/1237 | 93/8465 | 8.57e-09 | 1.48e-07 | 1.11e-07 | 36 |
hsa0452035 | Endometrium | EEC | Adherens junction | 36/1237 | 93/8465 | 8.57e-09 | 1.48e-07 | 1.11e-07 | 36 |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa049109 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0491014 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SORBS1 | insertion | Frame_Shift_Ins | novel | c.3464_3465insAGCTACTGAT | p.Asp1155GlufsTer12 | p.D1155Efs*12 | Q9BX66 | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
SORBS1 | insertion | Frame_Shift_Ins | novel | c.548_549insAGTGACA | p.Gly184ValfsTer28 | p.G184Vfs*28 | Q9BX66 | protein_coding | TCGA-AX-A05W-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SORBS1 | insertion | Frame_Shift_Ins | novel | c.3052_3053insGGCAC | p.Thr1018ArgfsTer23 | p.T1018Rfs*23 | Q9BX66 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SORBS1 | SNV | Missense_Mutation | rs781314841 | c.2542N>A | p.Glu848Lys | p.E848K | Q9BX66 | protein_coding | deleterious(0) | possibly_damaging(0.55) | TCGA-BC-A69H-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SORBS1 | SNV | Missense_Mutation | novel | c.211N>T | p.Val71Leu | p.V71L | Q9BX66 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.99) | TCGA-DD-AACY-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
SORBS1 | SNV | Missense_Mutation | c.58N>T | p.Ser20Cys | p.S20C | Q9BX66 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.759) | TCGA-KR-A7K8-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SORBS1 | SNV | Missense_Mutation | c.3644C>T | p.Pro1215Leu | p.P1215L | Q9BX66 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-44-5643-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD | |
SORBS1 | SNV | Missense_Mutation | c.1066N>C | p.Glu356Gln | p.E356Q | Q9BX66 | protein_coding | deleterious(0.01) | possibly_damaging(0.597) | TCGA-49-4505-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SORBS1 | SNV | Missense_Mutation | c.2259N>T | p.Glu753Asp | p.E753D | Q9BX66 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
SORBS1 | SNV | Missense_Mutation | c.3492N>C | p.Gln1164His | p.Q1164H | Q9BX66 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.598) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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