|
Gene: SLCO1A2 |
Gene summary for SLCO1A2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SLCO1A2 | Gene ID | 6579 |
Gene name | solute carrier organic anion transporter family member 1A2 | |
Gene Alias | OATP | |
Cytomap | 12p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024RAT5 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6579 | SLCO1A2 | C38 | Human | Oral cavity | OSCC | 1.66e-10 | 7.27e-01 | 0.172 |
6579 | SLCO1A2 | C06 | Human | Oral cavity | OSCC | 6.22e-04 | 4.95e-01 | 0.2699 |
6579 | SLCO1A2 | C08 | Human | Oral cavity | OSCC | 3.71e-12 | 2.26e-01 | 0.1919 |
6579 | SLCO1A2 | LN38 | Human | Oral cavity | OSCC | 1.18e-06 | 9.00e-01 | 0.168 |
6579 | SLCO1A2 | SYSMH1 | Human | Oral cavity | OSCC | 1.77e-03 | 8.17e-02 | 0.1127 |
Page: 1 |
Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | EOLP: Erosive Oral lichen planus | |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLCO1A2 | SNV | Missense_Mutation | c.1106N>A | p.Gly369Glu | p.G369E | P46721 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLCO1A2 | SNV | Missense_Mutation | novel | c.440C>T | p.Ser147Leu | p.S147L | P46721 | protein_coding | deleterious(0.01) | benign(0.012) | TCGA-IN-A6RO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | PD |
SLCO1A2 | SNV | Missense_Mutation | novel | c.1130N>C | p.Met377Thr | p.M377T | P46721 | protein_coding | deleterious(0) | benign(0.444) | TCGA-R5-A7ZR-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | TESTOSTERONE | TESTOSTERONE | 8779895 | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | inhibitor | 135652711 | RIFAMPIN | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | HORMONES | 8779894 | ||
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | hmg coa reductase inhibitors | |||
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | inhibitor | 178101291 | ||
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | rocuronium | ROCURONIUM | 28409297 | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | methotrexate | METHOTREXATE | 21317831 | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | 178101458 | |||
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | imatinib | IMATINIB | 21633340 | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | 178101232 |
Page: 1 2 |