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Gene: SLC7A14 |
Gene summary for SLC7A14 |
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Gene information | Species | Human | Gene symbol | SLC7A14 | Gene ID | 57709 |
Gene name | solute carrier family 7 member 14 | |
Gene Alias | PPP1R142 | |
Cytomap | 3q26.2 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | Q8TBB6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57709 | SLC7A14 | HCC1 | Human | Liver | HCC | 1.38e-10 | 1.55e+00 | 0.5336 |
57709 | SLC7A14 | HCC2 | Human | Liver | HCC | 1.62e-21 | 1.09e+00 | 0.5341 |
57709 | SLC7A14 | HCC5 | Human | Liver | HCC | 2.95e-14 | 1.11e+00 | 0.4932 |
57709 | SLC7A14 | S014 | Human | Liver | HCC | 7.96e-04 | 2.73e-01 | 0.2254 |
57709 | SLC7A14 | S016 | Human | Liver | HCC | 3.81e-08 | 3.58e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC7A14 | SNV | Missense_Mutation | c.82N>T | p.Arg28Cys | p.R28C | Q8TBB6 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SLC7A14 | SNV | Missense_Mutation | rs377481016 | c.790N>A | p.Ala264Thr | p.A264T | Q8TBB6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A14 | SNV | Missense_Mutation | rs146405741 | c.448N>A | p.Gly150Arg | p.G150R | Q8TBB6 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A14 | SNV | Missense_Mutation | rs763192459 | c.1046N>T | p.Ser349Ile | p.S349I | Q8TBB6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-7716-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC7A14 | SNV | Missense_Mutation | novel | c.1502A>C | p.Lys501Thr | p.K501T | Q8TBB6 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC7A14 | SNV | Missense_Mutation | c.2099N>G | p.Asp700Gly | p.D700G | Q8TBB6 | protein_coding | deleterious(0.01) | benign(0.239) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SLC7A14 | SNV | Missense_Mutation | rs371104588 | c.1067N>T | p.Pro356Leu | p.P356L | Q8TBB6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLC7A14 | SNV | Missense_Mutation | c.919T>G | p.Leu307Val | p.L307V | Q8TBB6 | protein_coding | deleterious(0.05) | probably_damaging(0.967) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SLC7A14 | SNV | Missense_Mutation | c.13N>G | p.Phe5Val | p.F5V | Q8TBB6 | protein_coding | tolerated_low_confidence(0.24) | benign(0) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
SLC7A14 | SNV | Missense_Mutation | rs766127625 | c.1766N>G | p.Tyr589Cys | p.Y589C | Q8TBB6 | protein_coding | tolerated(0.16) | benign(0.258) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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