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Gene: SLC5A12 |
Gene summary for SLC5A12 |
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Gene information | Species | Human | Gene symbol | SLC5A12 | Gene ID | 159963 |
Gene name | solute carrier family 5 member 12 | |
Gene Alias | SMCT2 | |
Cytomap | 11p14.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q1EHB4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
159963 | SLC5A12 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.85e-04 | 3.29e-01 | 0.0171 |
159963 | SLC5A12 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.56e-07 | 1.84e-01 | 0.0674 |
159963 | SLC5A12 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.38e-30 | 6.55e-01 | 0.3005 |
159963 | SLC5A12 | HCC1_Meng | Human | Liver | HCC | 1.17e-29 | 1.21e-01 | 0.0246 |
159963 | SLC5A12 | HCC1 | Human | Liver | HCC | 3.12e-03 | 2.49e+00 | 0.5336 |
159963 | SLC5A12 | HCC2 | Human | Liver | HCC | 5.93e-12 | 2.43e+00 | 0.5341 |
159963 | SLC5A12 | HCC5 | Human | Liver | HCC | 5.65e-04 | 2.47e-01 | 0.4932 |
159963 | SLC5A12 | S014 | Human | Liver | HCC | 3.54e-04 | 1.40e-01 | 0.2254 |
159963 | SLC5A12 | S016 | Human | Liver | HCC | 1.12e-03 | 1.34e-01 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC5A12 | SNV | Missense_Mutation | c.1366N>A | p.Ala456Thr | p.A456T | Q1EHB4 | protein_coding | deleterious(0.01) | benign(0.341) | TCGA-EJ-A65G-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD | |
SLC5A12 | SNV | Missense_Mutation | c.898C>T | p.His300Tyr | p.H300Y | Q1EHB4 | protein_coding | tolerated(1) | benign(0.001) | TCGA-BR-A4PE-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC5A12 | SNV | Missense_Mutation | rs142065702 | c.227G>A | p.Arg76His | p.R76H | Q1EHB4 | protein_coding | deleterious(0.01) | possibly_damaging(0.534) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
SLC5A12 | insertion | Frame_Shift_Ins | novel | c.245_246insGAAAATCAGTG | p.Val83LysfsTer16 | p.V83Kfs*16 | Q1EHB4 | protein_coding | TCGA-IM-A41Z-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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