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Gene: SLC34A2 |
Gene summary for SLC34A2 |
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Gene information | Species | Human | Gene symbol | SLC34A2 | Gene ID | 10568 |
Gene name | solute carrier family 34 member 2 | |
Gene Alias | NAPI-3B | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | O95436 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10568 | SLC34A2 | CA_HPV_1 | Human | Cervix | CC | 1.65e-18 | -6.59e-01 | 0.0264 |
10568 | SLC34A2 | CA_HPV_2 | Human | Cervix | CC | 3.12e-19 | -6.59e-01 | 0.0391 |
10568 | SLC34A2 | CA_HPV_3 | Human | Cervix | CC | 5.24e-12 | -6.39e-01 | 0.0414 |
10568 | SLC34A2 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 4.11e-07 | -5.56e-01 | 0.0116 |
10568 | SLC34A2 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 1.73e-06 | -3.22e-01 | 0.0208 |
10568 | SLC34A2 | N_HPV_1 | Human | Cervix | N_HPV | 4.64e-05 | -5.55e-01 | 0.0079 |
10568 | SLC34A2 | N_HPV_2 | Human | Cervix | N_HPV | 3.16e-09 | -5.37e-01 | -0.0131 |
10568 | SLC34A2 | CCI_1 | Human | Cervix | CC | 7.94e-05 | -6.59e-01 | 0.528 |
10568 | SLC34A2 | CCI_3 | Human | Cervix | CC | 5.93e-07 | -6.59e-01 | 0.516 |
10568 | SLC34A2 | CCII_1 | Human | Cervix | CC | 3.24e-10 | -6.59e-01 | 0.3249 |
10568 | SLC34A2 | Tumor | Human | Cervix | CC | 3.12e-19 | -6.59e-01 | 0.1241 |
10568 | SLC34A2 | sample1 | Human | Cervix | CC | 2.68e-08 | -6.59e-01 | 0.0959 |
10568 | SLC34A2 | sample3 | Human | Cervix | CC | 1.65e-18 | -6.59e-01 | 0.1387 |
10568 | SLC34A2 | H2 | Human | Cervix | HSIL_HPV | 3.00e-05 | -1.50e-01 | 0.0632 |
10568 | SLC34A2 | L1 | Human | Cervix | CC | 2.38e-11 | -6.59e-01 | 0.0802 |
10568 | SLC34A2 | T1 | Human | Cervix | CC | 2.66e-17 | -6.53e-01 | 0.0918 |
10568 | SLC34A2 | T3 | Human | Cervix | CC | 3.12e-19 | -6.59e-01 | 0.1389 |
10568 | SLC34A2 | P1T-E | Human | Esophagus | ESCC | 4.99e-02 | 1.04e+00 | 0.0875 |
10568 | SLC34A2 | P8T-E | Human | Esophagus | ESCC | 4.79e-17 | 8.98e-01 | 0.0889 |
10568 | SLC34A2 | P16T-E | Human | Esophagus | ESCC | 5.90e-04 | 1.22e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00017018 | Cervix | CC | in utero embryonic development | 71/2311 | 367/18723 | 7.21e-05 | 1.00e-03 | 71 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:00436275 | Esophagus | ESCC | response to estrogen | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
GO:00017015 | Liver | Cirrhotic | in utero embryonic development | 134/4634 | 367/18723 | 2.78e-07 | 6.86e-06 | 134 |
GO:0043627 | Liver | Cirrhotic | response to estrogen | 30/4634 | 75/18723 | 2.52e-03 | 1.51e-02 | 30 |
GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
GO:00436271 | Liver | HCC | response to estrogen | 44/7958 | 75/18723 | 3.44e-03 | 1.55e-02 | 44 |
GO:00017016 | Lung | IAC | in utero embryonic development | 68/2061 | 367/18723 | 1.12e-05 | 3.45e-04 | 68 |
GO:0006817 | Lung | IAC | phosphate ion transport | 8/2061 | 24/18723 | 3.09e-03 | 2.71e-02 | 8 |
GO:000170112 | Lung | AIS | in utero embryonic development | 59/1849 | 367/18723 | 1.20e-04 | 2.75e-03 | 59 |
GO:000170121 | Lung | AAH | in utero embryonic development | 24/613 | 367/18723 | 1.09e-03 | 3.25e-02 | 24 |
GO:000170131 | Lung | MIAC | in utero embryonic development | 33/967 | 367/18723 | 1.44e-03 | 2.54e-02 | 33 |
GO:000170125 | Thyroid | HT | in utero embryonic development | 39/1272 | 367/18723 | 3.72e-03 | 2.78e-02 | 39 |
GO:0001701111 | Thyroid | PTC | in utero embryonic development | 175/5968 | 367/18723 | 1.40e-10 | 4.73e-09 | 175 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0492812 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa0492813 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa0492816 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0492817 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0492810 | Lung | IAC | Parathyroid hormone synthesis, secretion and action | 26/1053 | 106/8465 | 4.34e-04 | 4.03e-03 | 2.68e-03 | 26 |
hsa0492811 | Lung | IAC | Parathyroid hormone synthesis, secretion and action | 26/1053 | 106/8465 | 4.34e-04 | 4.03e-03 | 2.68e-03 | 26 |
hsa0492821 | Lung | AIS | Parathyroid hormone synthesis, secretion and action | 22/961 | 106/8465 | 3.45e-03 | 1.90e-02 | 1.21e-02 | 22 |
hsa0492831 | Lung | AIS | Parathyroid hormone synthesis, secretion and action | 22/961 | 106/8465 | 3.45e-03 | 1.90e-02 | 1.21e-02 | 22 |
hsa0492841 | Lung | MIAC | Parathyroid hormone synthesis, secretion and action | 17/507 | 106/8465 | 1.69e-04 | 3.51e-03 | 2.54e-03 | 17 |
hsa0492851 | Lung | MIAC | Parathyroid hormone synthesis, secretion and action | 17/507 | 106/8465 | 1.69e-04 | 3.51e-03 | 2.54e-03 | 17 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC34A2 | SNV | Missense_Mutation | c.2063N>T | p.Thr688Met | p.T688M | O95436 | protein_coding | deleterious_low_confidence(0) | benign(0.159) | TCGA-BJ-A2NA-01 | Thyroid | thyroid carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
SLC34A2 | SNV | Missense_Mutation | novel | c.1864N>C | p.Cys622Arg | p.C622R | O95436 | protein_coding | tolerated(0.09) | probably_damaging(0.994) | TCGA-FE-A232-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC34A2 | insertion | Frame_Shift_Ins | novel | c.598dupG | p.Ala200GlyfsTer10 | p.A200Gfs*10 | O95436 | protein_coding | TCGA-ET-A3DW-01 | Thyroid | thyroid carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10568 | SLC34A2 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME | antibody | 252166615 |
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