![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SIN3B |
Gene summary for SIN3B |
![]() |
Gene information | Species | Human | Gene symbol | SIN3B | Gene ID | 23309 |
Gene name | SIN3 transcription regulator family member B | |
Gene Alias | SIN3B | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O75182 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23309 | SIN3B | LZE4T | Human | Esophagus | ESCC | 1.24e-04 | 1.55e-01 | 0.0811 |
23309 | SIN3B | LZE5T | Human | Esophagus | ESCC | 3.77e-03 | 1.94e-01 | 0.0514 |
23309 | SIN3B | LZE7T | Human | Esophagus | ESCC | 1.43e-04 | 1.56e-01 | 0.0667 |
23309 | SIN3B | LZE20T | Human | Esophagus | ESCC | 9.17e-03 | 1.18e-01 | 0.0662 |
23309 | SIN3B | LZE24T | Human | Esophagus | ESCC | 3.51e-09 | 2.79e-01 | 0.0596 |
23309 | SIN3B | P1T-E | Human | Esophagus | ESCC | 5.31e-11 | 3.41e-01 | 0.0875 |
23309 | SIN3B | P2T-E | Human | Esophagus | ESCC | 2.38e-15 | 2.55e-01 | 0.1177 |
23309 | SIN3B | P4T-E | Human | Esophagus | ESCC | 2.72e-20 | 2.82e-01 | 0.1323 |
23309 | SIN3B | P5T-E | Human | Esophagus | ESCC | 1.80e-34 | 5.55e-01 | 0.1327 |
23309 | SIN3B | P8T-E | Human | Esophagus | ESCC | 1.54e-15 | 2.98e-01 | 0.0889 |
23309 | SIN3B | P9T-E | Human | Esophagus | ESCC | 4.41e-12 | 3.04e-01 | 0.1131 |
23309 | SIN3B | P10T-E | Human | Esophagus | ESCC | 1.81e-25 | 4.55e-01 | 0.116 |
23309 | SIN3B | P11T-E | Human | Esophagus | ESCC | 2.46e-14 | 5.73e-01 | 0.1426 |
23309 | SIN3B | P12T-E | Human | Esophagus | ESCC | 4.57e-15 | 3.08e-01 | 0.1122 |
23309 | SIN3B | P15T-E | Human | Esophagus | ESCC | 1.98e-20 | 3.86e-01 | 0.1149 |
23309 | SIN3B | P16T-E | Human | Esophagus | ESCC | 7.32e-13 | 2.15e-01 | 0.1153 |
23309 | SIN3B | P17T-E | Human | Esophagus | ESCC | 1.55e-15 | 5.03e-01 | 0.1278 |
23309 | SIN3B | P19T-E | Human | Esophagus | ESCC | 2.95e-02 | 3.18e-01 | 0.1662 |
23309 | SIN3B | P20T-E | Human | Esophagus | ESCC | 7.03e-18 | 1.93e-01 | 0.1124 |
23309 | SIN3B | P21T-E | Human | Esophagus | ESCC | 9.17e-25 | 4.99e-01 | 0.1617 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:00165707 | Oral cavity | OSCC | histone modification | 270/7305 | 463/18723 | 1.59e-17 | 1.50e-15 | 270 |
GO:00356014 | Oral cavity | OSCC | protein deacylation | 74/7305 | 112/18723 | 5.88e-09 | 1.26e-07 | 74 |
GO:00987324 | Oral cavity | OSCC | macromolecule deacylation | 74/7305 | 116/18723 | 5.52e-08 | 1.01e-06 | 74 |
GO:00064764 | Oral cavity | OSCC | protein deacetylation | 66/7305 | 101/18723 | 7.36e-08 | 1.30e-06 | 66 |
GO:00165753 | Oral cavity | OSCC | histone deacetylation | 54/7305 | 82/18723 | 7.68e-07 | 1.08e-05 | 54 |
GO:001657010 | Thyroid | PTC | histone modification | 235/5968 | 463/18723 | 1.17e-17 | 1.15e-15 | 235 |
GO:00356017 | Thyroid | PTC | protein deacylation | 58/5968 | 112/18723 | 9.29e-06 | 1.05e-04 | 58 |
GO:00165756 | Thyroid | PTC | histone deacetylation | 45/5968 | 82/18723 | 1.34e-05 | 1.45e-04 | 45 |
GO:00064767 | Thyroid | PTC | protein deacetylation | 53/5968 | 101/18723 | 1.36e-05 | 1.47e-04 | 53 |
GO:00987327 | Thyroid | PTC | macromolecule deacylation | 58/5968 | 116/18723 | 3.59e-05 | 3.36e-04 | 58 |
GO:001657017 | Thyroid | ATC | histone modification | 243/6293 | 463/18723 | 2.23e-17 | 2.27e-15 | 243 |
GO:003560114 | Thyroid | ATC | protein deacylation | 61/6293 | 112/18723 | 4.37e-06 | 4.79e-05 | 61 |
GO:000647614 | Thyroid | ATC | protein deacetylation | 56/6293 | 101/18723 | 5.15e-06 | 5.57e-05 | 56 |
GO:001657512 | Thyroid | ATC | histone deacetylation | 47/6293 | 82/18723 | 8.75e-06 | 8.81e-05 | 47 |
GO:009873213 | Thyroid | ATC | macromolecule deacylation | 61/6293 | 116/18723 | 1.89e-05 | 1.72e-04 | 61 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIN3B | SNV | Missense_Mutation | novel | c.815N>T | p.Pro272Leu | p.P272L | O75182 | protein_coding | deleterious(0) | benign(0.011) | TCGA-DQ-5629-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
SIN3B | SNV | Missense_Mutation | novel | c.1155N>G | p.Ile385Met | p.I385M | O75182 | protein_coding | tolerated(0.19) | benign(0.011) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SIN3B | SNV | Missense_Mutation | novel | c.2164N>A | p.Gly722Arg | p.G722R | O75182 | protein_coding | tolerated(0.06) | benign(0.028) | TCGA-UF-A7JT-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SIN3B | SNV | Missense_Mutation | rs781358567 | c.841N>T | p.Pro281Ser | p.P281S | O75182 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-KC-A7FA-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
SIN3B | SNV | Missense_Mutation | rs752227470 | c.1150G>A | p.Gly384Arg | p.G384R | O75182 | protein_coding | deleterious(0.02) | possibly_damaging(0.475) | TCGA-TP-A8TT-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
SIN3B | SNV | Missense_Mutation | c.2079G>C | p.Gln693His | p.Q693H | O75182 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SIN3B | SNV | Missense_Mutation | c.3203N>C | p.Ile1068Thr | p.I1068T | O75182 | protein_coding | tolerated(0.11) | benign(0.044) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIN3B | SNV | Missense_Mutation | c.1876N>G | p.Asn626Asp | p.N626D | O75182 | protein_coding | deleterious(0) | possibly_damaging(0.696) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIN3B | SNV | Missense_Mutation | rs371313884 | c.1705G>A | p.Val569Ile | p.V569I | O75182 | protein_coding | tolerated(0.72) | benign(0.01) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SIN3B | SNV | Missense_Mutation | rs768108165 | c.2794N>T | p.Arg932Cys | p.R932C | O75182 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |